Managing Dissolved Air Throughout Freeze-Thaw Process to Reduce Aggregation of Human Serum Albumin [0.03%]
调控冻融过程中溶解空气含量以减少人血清白蛋白聚集
Neela Nahar Nazmun,Huy M Dao
Neela Nahar Nazmun
Freeze-thaw (FT) stress compromises protein stability through ice crystal formation and exposure to air-liquid and ice-liquid interfaces. This study investigated whether deaeration could mitigate Human Serum Albumin (HSA) aggregation by lim...
Palatability-by-Design for Oral Drug Products: A Unified Framework for Evaluation and Optimization [0.03%]
口服药物产品的可接受性设计：评估和优化的统一框架
Qiaorui Li,Junzhe Xi,Zhenda Liu et al.
Qiaorui Li et al.
Palatability is a critical determinant of acceptability and adherence for oral drug products, especially in pediatric and geriatric populations, yet its evaluation remains fragmented across dosage forms and often disconnected from formulati...
Engineering Bilosomal Nanocarriers for Targeted Delivery of Resveratrol: Rational Design, Radiotracking Insights and Cytotoxic Assessment [0.03%]
用于白藜芦醇靶向递送的双层脂体纳米载体的理性设计、放射示踪研究和细胞毒性评估
Khaled M Attallah,Shymaa Hatem,Marwa Eid Sayyed
Khaled M Attallah
Colorectal cancer (CRC) is a major cause of cancer-related death. Resveratrol (RES), despite its promising anti-inflammatory, antioxidant, and anticancer properties, suffers from poor solubility, low bioavailability, and limited tumor accum...
Impact of Amino Acid Excipients on icIEF Method Development in Protein Therapeutics: A Formulation-Aware Analytical Framework [0.03%]
基于制剂的反相离子交换色谱法在蛋白药物分析中的作用机制及应用框架研究
Pragya Manandhar,Nicole Payung,Siddharth Sapa et al.
Pragya Manandhar et al.
Accurate assessment of charge heterogeneity and isoelectric point (pI) is essential for ensuring the quality, stability, and safety of biotherapeutics throughout development and commercialization. Imaged capillary isoelectric focusing (icIE...
Design, Optimization and Pharmacokinetic Profiling of BCS Class II Drug Loaded Oral Self Nanoemulsifying System [0.03%]
口服自微乳化药物递送系统的设计、优化及药动学研究
Ayon Dutta,Swarupananda Mukherjee,Biswajit Basu et al.
Ayon Dutta et al.
The orally administered self nano emulsifying drug delivery system (SNEDDS), an uniform blend with nano scaled globules, is composed of oil, surfactant and co-surfactant. The aim of the investigation was to develop and optimize Nicardipine ...
Development and Evaluation of Tofacitinib Tablets with Comparative Dissolution and Pharmacokinetic Studies in Beagle Dogs [0.03%]
托法替尼片剂的开发与评价： comparative dissolution和pharmacokinetic研究在比格犬中的应用
Deokkyu Lee,Jain Koo,Hyewon Jeon et al.
Deokkyu Lee et al.
Tofacitinib (Tofa), a Biopharmaceutics Classification System Class III drug, exhibits pH-dependent solubility and a strong tendency to agglomerate, potentially affecting tablet uniformity, in vitro dissolution behavior, and in vivo performa...
Comparative Study
AAPS PharmSciTech. 2026 May 6;27(4):202. DOI:10.1208/s12249-026-03444-0 2026
PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction [0.03%]
聚乙二醇化黄酮类药物囊泡作为脑靶向纳米小分子载体平台增强应激诱导的认知障碍的神经保护作用
Amal Fathy Aladoly,Maha M Amin,Heba Nasr Shalaby et al.
Amal Fathy Aladoly et al.
Luteolin (LUT) is a biologically active flavonoid exhibiting significant therapeutic potential against neurodegenerative disorders such as cognitive impairment. Nonetheless, its clinical application is limited by poor aqueous solubility, ex...
Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections [0.03%]
含有多西环素及多西环素与恩曲他滨和特鲁瓦达相结合的用于预防性传播感染的局部植入剂配方开发
Vivek Agrahari,M Melissa Peet,Jasmin Monpara et al.
Vivek Agrahari et al.
Despite advances in oral and injectable HIV prevention options and oral prophylaxis for sexually transmitted infections (STIs) of bacterial origin, there remains a critical need for effective on-demand topical (vaginal and rectal) products ...
From Digital Design to Dosage Performance: Material-Process-Geometry Interactions in 3D-Printed Oral Tablets [0.03%]
从数字设计到剂量性能：三维打印口服片剂的材料-工艺-几何相互作用
Aarya Rajendra Menkudale,Prerana V Poojary,Swohinee Sarkar et al.
Aarya Rajendra Menkudale et al.
Additive manufacturing (AM) allows for digital control of the geometry, internal design, and dosage of oral solid dosage forms, thus broadening the horizon of applications. However, the release of drugs from 3D-printed tablets is often expl...
Advancement in Sodium Alginate-Based Drug Delivery Systems: Applications and Future Prospects [0.03%]
基于海藻酸钠的药物递送系统进展：应用和前景展望
Anjali Kumari,Bonthu Varunteja,Satyajit Mohanty et al.
Anjali Kumari et al.
For over five decades, sodium alginate (SA) has been widely employed in pharmaceutical formulations due to its environmentally friendly, biodegradable, and biocompatible nature. Primarily sourced from brown seaweed, this natural polymer pla...