Formulation, Characterization, and Optimization of Ascorbic Acid-Loaded Chitosan Nanoparticles: Investigating the Impact of pH and Ionic Crosslinking Parameters [0.03%]
基于pH和离子交联参数的抗坏血酸-壳聚糖载药纳米粒体系的构建、表征及优化研究
Wasfy M Obeidat,Abdolelah Jaradat
Wasfy M Obeidat
Chitosan nanoparticles are promising carriers for the delivery of labile bioactive compounds, yet the complex interplay between formulation parameters-particularly pH, crosslinker concentration, and drug loading-remains incompletely underst...
Comparative Study of Rotigotine Release and Permeation from the Neupro® Transdermal Patch: An In Vitro-In Vivo Correlation [0.03%]
体外-体内相关性比较研究尼复平等透皮贴剂罗替戈汀释放及渗透行为
Thamara de Carvalho Mendes,Hellen Regina Oliveira de Almeida,Lucio Mendes Cabral et al.
Thamara de Carvalho Mendes et al.
Rotigotine (RTG) is a non-ergolinic dopaminergic agonist indicated for Parkinson's and Willis-Ekbom diseases, administered exclusively via Neupro® transdermal patch. Given the therapeutic relevance and physicochemical challenges of RTG, th...
Comparative Study
AAPS PharmSciTech. 2026 May 23;27(5):217. DOI:10.1208/s12249-026-03393-8 2026
Development and Characterization of Ginsenoside-Aconitum Lipidic Cubic Nanoparticle-Loaded Dissolving Microneedles for Enhanced Transdermal Anti-inflammatory Therapy [0.03%]
一种新型人参皂苷-附子液晶纳米粒溶解微针的开发及透皮抗炎研究
Yang Liu,Yaqian Wang,Sinan Wu et al.
Yang Liu et al.
A dual-drug transdermal delivery system was developed by co-encapsulating Panax notoginseng total saponins (PNS) and Aconitum alkaloids into lipidic cubic nanoparticles (LCNPs) and incorporating them into dissolving microneedles (DMNs). Hig...
Safety and Efficacy of Inhaled Natural Product Powders That Enhance Mucociliary Clearance [0.03%]
改善黏液清除功能的吸入型天然植物粉末的安全性和有效性
Dale J Christensen,Zachary Warnken,Daria Stoltz et al.
Dale J Christensen et al.
Mucociliary clearance is the lung's primary defense against inhaled pathogens and particulates, requiring optimal airway surface liquid hydration, mucus rheology, and coordinated ciliary beating. Diseases and pollutants disrupt these proces...
Quality-by-design-based fabrication of betaxolol hydrochloride-loaded nano-ocular carrier via ternary phase mapping of solid/liquid lipids and BBD modeling for enhanced transcorneal flux and IOP-lowering effect [0.03%]
基于质量源于设计的betaxolol盐酸盐载药纳米眼用给药系统制备及其透角膜传递和降眼压效应增强研究
Nishant Kumar,Anoop Kumar,Sokindra Kumar
Nishant Kumar
The anti-glaucoma drug betaxolol hydrochloride (BH) exhibits poor ocular bioavailability due to limited corneal permeability, rapid precorneal loss, short retention time, and lacrimal drainage when administered conventionally. In the presen...
Effects of Different Carriers on the Stability and Pharmacokinetic Performance of Cucurbitacin B Solid Dispersions [0.03%]
不同载体对葫芦素B固体分散体制备稳定性及药动学性能的影响
Siri Huang,Qian Wu,Yabo Ren et al.
Siri Huang et al.
Cucurbitacin B (CuB) is a highly oxidized tetracyclic triterpenoid classified as a Biopharmaceutics Classification System class (BCS) IV drug. Its poor solubility and low permeability significantly limit its clinical use. In an initial stud...
In vitro Evaluation of Hydroxypropyl-β-cyclodextrin Effects on Rhein Flux Across Microneedle-pretreated Skin [0.03%]
羟丙基-β-环糊精对地奥酚溶液经微针预处理皮肤透过量的体外影响研究
Kamchai Saepang,Puwich Chaikhumwang,Benjaporn Buranrat et al.
Kamchai Saepang et al.
Solid drug-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complexes are used to enhance drug solubility and microneedle (MN)-mediated delivery efficiency. However, mechanistic understanding of HPβCD effects in solution on drug transport ...
Formulation, Optimization and In vivo Evaluation of Freeze-Dried Nanocapsules for Enhancing the Oral Delivery of Valsartan [0.03%]
用于增强缬沙坦口服递送的冷冻干燥纳米胶囊的配方、优化和体内评价
Asmaa H Abdelhameed,Usama Farghaly,Zeinab M Fathalla et al.
Asmaa H Abdelhameed et al.
This study aims to develop the freeze-dried core-shell nanoparticles (nanocapsules; NCs) as an effective dosage form for improving the therapeutic activity of valsartan (VAL). NCs were created employing the nanoprecipitation process and opt...
Identifying Optimal Drug Loading in Stable Amorphous Solid Dispersion Formulations: A Rheological Approach [0.03%]
稳定无定形固体分散体制剂中识别 optimal 药物载量的流变学方法
Sagar Narala,Fengyuan Yang,Kapish Karan et al.
Sagar Narala et al.
Synthetic polymers play a crucial role in enhancing the performance of drug formulations by enabling controlled release, improving bioavailability, and ensuring stability. Copovidone is frequently employed as an excipient in hot-melt extrus...
Bridging Therapeutics and Nanotechnology in Dry Eye Disease: A Review of Risk Factors, Drug Delivery Barriers, and Recent and Future Endeavors for Disease Management [0.03%]
干眼病的治疗与纳米技术：风险因素、药物输送障碍及疾病管理的近期和未来尝试综述
Mayar Salama,Islam M Adel,Randa Tag et al.
Mayar Salama et al.
Dry eye disease (DED) is a multifactorial ocular disorder with high prevalence among global population, characterized by tear film instability, hyperosmolarity, and ocular surface inflammation, leading to impaired vision and reduced quality...