Novel Pathways for Non-invasive Laser-assisted Drug Delivery: A Critical Review [0.03%]
激光辅助药物输送的新途径：综述性批判文章
Dilpreet Singh,Lalu Mohammad Irham
Dilpreet Singh
Laser-induced molecular transport has emerged as a highly effective and non-invasive approach for enhancing drug delivery systems, offering targeted and controlled release of therapeutic agents with minimal systemic toxicity. This review ex...
Integrating Quality by Design (QbD) in Phytosomal Drug Delivery: A New Era in Precision Phytotherapy [0.03%]
质量源于设计(QbD)在植物药物传递中的整合：精准植物治疗的新时代
Sumant Kumar,Omar Awad Alsaidan,Sami I Alzarea et al.
Sumant Kumar et al.
Quality by Design (QbD) has emerged as a systematic and proactive approach in pharmaceutical development, ensuring consistent product quality through a thorough understanding of formulation components and critical process parameters. In the...
Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions [0.03%]
纳米囊泡药物递送系统在罕见眼科疾病中的应用：进展、挑战与未来方向
Shaheen Sultana,Mohammad Yusuf,Vikram Sharma
Shaheen Sultana
The present work focuses on investigating the potential of nanovesicular drug and gene delivery systems in addressing therapeutic challenges associated with rare ocular diseases, including Leber's congenital amaurosis, retinitis pigmentosa,...
Geetha Nayak,Usha Y Nayak
Geetha Nayak
Hot melt extrusion (HME) is a widely used method of taste masking in medication formulations, notably for bitter Active Pharmaceutical Ingredients (APIs). This continuous, solvent-free technique successfully wraps APIs within a polymer matr...
Exploring the Therapeutic Potential of Lipid Nanocarriers in Psoriasis Management: Advances and Applications [0.03%]
脂质纳米载体在银屑病管理中的治疗潜力探索：进展与应用
Atif Husain,Poonam Kushwaha,Archita Kapoor et al.
Atif Husain et al.
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and immune dysregulation, leading to erythematous, scaly plaques. Conventional treatments, including corticosteroids, immunosuppressants,...
Exploration of Predictive Potential of AI-enabled Portable System in Anticancer Drug Delivery: A Comparative Study with Modified Gompertz like Biphasic Response Model [0.03%]
基于人工智能的便携式系统在抗癌药物递送中的预测潜力探索：与改良Gompertz双相响应模型比较研究
Subeel Shah,Kapil Saraswat,Charu Misra et al.
Subeel Shah et al.
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management,...
Comparative Study
AAPS PharmSciTech. 2025 Jul 16;26(7):194. DOI:10.1208/s12249-025-03193-6 2025
Alternative Syringe and Needle Design for Clog-free Delivery of High-concentration Suspensions [0.03%]
用于高浓度悬浮液无堵塞输送的替代注射器和针头设计
Kavin Kowsari,John Cline,Steven C Persak et al.
Kavin Kowsari et al.
Needle clogging is one of the key challenges in delivery of suspension (i.e., multi-phase) formulations. It is a phenomenon by which the particles (i.e., solid phase) accumulate locally to occlude the flow, leading to injection failure. Thi...
Integration of Design of Experiments for the Development and Evaluation of Sulfasalazine Loaded Hybrid Albumin Chitosan Based Polymeric Nanocarriers [0.03%]
基于白蛋白壳聚糖聚合物纳米载体的硫嘌呤药物的设计、发展和评估中的试验设计集成研究
Sushrut Marathe,Rohit Joshi,Rongbing Yang et al.
Sushrut Marathe et al.
Sulfasalazine is a sepiapterin reductase and System x - c inhibitor with anti-neuroblastoma activity. The objective was to develop cellular redox glutathione stimuli-responsive Sulfasalazine-loaded albumin-chitosan hybrid nanocarriers with ...
Nanotechnology in Uveal Melanoma: Cutting-Edge Advances to Halt Progression and Metastasis [0.03%]
纳米技术在虹膜黑色素瘤中的应用：阻止进展和转移的前沿进展
Rohit Bhawale,Omar Khan,Ravindra Vasave et al.
Rohit Bhawale et al.
Uveal melanoma (UM) represents the most prevalent primary intraocular malignancy in adults, distinguished by its aggressive progression and significant propensity for metastasis, predominantly to the liver and lungs. Despite advances in dia...
Phospholipid-Drug Conjugates in Cancer Therapy: Emerging Paradigms and Future Directions [0.03%]
癌症治疗中磷脂-药物偶联物的新范式和未来方向
Kiran Dudhat,Harsh Pirojiya,Krupali Bhalala et al.
Kiran Dudhat et al.
Phospholipid-drug conjugates (PDCs) represent a novel advancement in cancer therapy, combining the therapeutic potential of active drug molecules with the biocompatibility and targeting benefits of phospholipids. Conventional cancer treatme...