An Updated Perspective on Skin Disease Therapy: From Conventional Methods to Nanocarrier Innovations [0.03%]
皮肤疾病治疗的新视角：从传统方法到纳米载体创新
Riya Shivgotra,Bindu Soni,Parminder Kaur et al.
Riya Shivgotra et al.
Skin conditions are becoming more prevalent these days, affecting millions of people daily. Skin disorders include a wide range of conditions that can be benign or even fatal. Several pathogenic infections or inflammatory conditions have hi...
Cab-O-Sil®M-5P Integrated Solidified Phytosomes: A Novel Strategy to Enhance the Solubility, In Vitro Dissolution and Pharmacokinetic Performance of Ferulic Acid [0.03%]
万能二氧化硅M-5P固化的植物体：增强阿魏酸溶解性、离体溶解度和药动学性能的新策略
Amol S Warokar,Darshan R Telange,Bhawna S Dumbhare et al.
Amol S Warokar et al.
Phytosomes, i.e., phospholipid complexes, are a vesicular drug delivery system engineered to enhance the biopharmaceutical and pharmacokinetics of poorly water-soluble phytoconstituents. However, the stickiness of the phytosomes causes thei...
Targeted Drug Delivery for Breast Cancer using Functionalized Liposomes: Preparation Methods, Challenges, and Clinical Translation [0.03%]
功能化脂质体制备、挑战及临床转化在乳腺癌靶向治疗中的应用研究
Amlan Bishal,Priyadarshini Paul,Sayan Bera et al.
Amlan Bishal et al.
Breast cancer continues to be a major cause to cancer-related deaths globally, highlighting the urgent need for more targeted and efficient treatment approaches. This review focuses on targeted drug delivery systems using functionalized lip...
Advancements in Liposomal Drug Delivery Systems for Paediatric Neurological Disorders: A Comprehensive Review [0.03%]
儿科神经系统疾病脂质体药物递送系统进展：综述文章
Parvathy Hari,Safa A Vahab,Vrinda S Kumar
Parvathy Hari
Paediatric neurological conditions pose many challenges for treatment because of the dynamic properties of the developing nervous system. Special therapeutic interventions are necessary to cope with these alterations because they are freque...
Evaluating 3D-Printed Pre-separator Inserts in a Fast Screening Impactor for Physicochemical Characterization of Fine Particle Dose Release from Dry Powder Inhalers [0.03%]
三维打印预分离器在快速筛分撞击器中的应用以表征干粉吸入器中细颗粒剂量的理化性质
Nathan A Reed,Roee Dar,Nicholas Holtgrewe et al.
Nathan A Reed et al.
There is growing demand for simplified collection of the fine particle dose (FPD, mass of particles less than 5 µm in diameter) of orally inhaled drug products (OIDPs) for physicochemical characterization. Dissolution kinetics of the FPD a...
Development, Characterization, and in vitro Efficacy Evaluation of an Inhalable H1B Antimicrobial Peptide Formulation for Treating Non-Small Cell Lung Cancer [0.03%]
一种用于治疗非小细胞肺癌的可吸入H1B抗菌肽制剂的开发、表征及体外疗效评估
Alec M Diorio,Apoorva Daram,Nandhini Sriram et al.
Alec M Diorio et al.
Hymenochirin-1B (H1B) is a linear alpha-helical amphipathic anti-microbial peptide originally isolated from the skin secretions of the Congo-clawed frog Hymenochirus boettgeri (Pipidae). H1B has previously shown anticancer activity in non-s...
Rational QbD-based Assessment of Formulation Ingredients' Impact on Sustainable Sunscreen Physical Stability [0.03%]
基于理性质量源于设计的评估制剂成分对环保型防晒物理稳定性的影響
Larissa Carniel,Marina Gomes,Giovana Carolina Bazzo et al.
Larissa Carniel et al.
Traditionally, cosmetic emulsions have been developed using trial-and-error approaches, which can be ineffective and time-consuming. This study employed a Quality by Design approach to determine how formulation ingredients impact the physic...
Fast-Dissolving Pullulan Film as a Solid Dosage Form for Sublingual Administration of Nifedipine-Loaded Nanocapsules [0.03%]
用于舌下给药的尼尔德平纳米囊载药海藻糖素快速溶解膜固体制剂
Bárbara Felin Osmari,Giovana Aime Medeiros,Lucas Saldanha da Rosa et al.
Bárbara Felin Osmari et al.
Fast-dissolving pullulan films were developed as a final dosage form for the sublingual administration of nanocapsules containing nifedipine (NIFE). Eudragit® RS100 nanocapsule suspensions presenting 1 mg/mL of NIFE, 150 nm in size, and po...
In-vitro Evaluation of p-Sulfonatocalix[n] arenes (SCnA) as Novel Excipients Using a Vectorized BCS Approach [0.03%]
基于BCS的载体方法筛选新型辅料p-磺酸卡箱[n]烃（SCnA）的体外评价研究
Lihua Tan,Zhongli Jing,Na Li et al.
Lihua Tan et al.
This study introduced a novel vectorized Biopharmaceutics Classification System (BCS) model designed to evaluate the biopharmaceutical properties of active pharmaceutical ingredients (APIs) and their variations under different influencing f...
Influence of Hydrophobic Ion Pairing on Formulation Performance of Liraglutide in PLGA Microspheres [0.03%]
疏水性离子对在PLGA微球中利拉鲁肽制剂性能中的作用研究
Jyotsna G Vitore,Varla Yalamanda,Devendra Singh Tomar et al.
Jyotsna G Vitore et al.
The Food and Drug Administration of the United States (USFDA) and the European Medicines Agency (EMA) have approved peptide-based long-acting formulations to manage chronic diseases. However, the formulation of long-acting injectables for h...