Functional Hybrid Wound Scaffolds for Controlled Drug Delivery and Smart Wound Management: A Decade of Progress [0.03%]
用于控制药物输送和智能伤口管理的多功能杂化伤口支架：十年来的进展
Riya Patel,Shreeraj Shah,Bhupendra Prajapati
Riya Patel
In order to avoid exogenous infections and promote healing, wound scaffolds (WS), an artificial barrier that separates the damaged location from the outside world, are a crucial part of wound care. Traditional wound dressings are widely use...
From Parenteral to Oral Delivery: Facile Formulation of Oral Gemcitabine Nanospanlastics for Enhanced Bioavailability and Anticancer Activity in Murine Breast Cancer Model [0.03%]
从注射给药到口服给药：简便的口服吉西他滨纳米前药制剂用于增强小鼠乳腺癌模型中的生物利用度和抗肿瘤活性
Safaa E Ramadan,Suleiman S Eltokhy,Sanaa A El-Gizawy et al.
Safaa E Ramadan et al.
Gemcitabine hydrochloride (GEM) is a commonly used antineoplastic that is delivered only by intravenous infusion due to its limited oral bioavailability of 10%. The study aims to design and optimize novel Spanlastics (GEM-SLs) to improve th...
Comparison of Chitosan-Poloxamer Nanoparticles and Poloxamer-based In-Situ Forming Gel for Nose-to-Brain Delivery of Cetrorelix: In Vitro and Pharmacokinetic Studies in Rats [0.03%]
壳聚糖-泊洛沙姆纳米颗粒和用于鼻脑递送的泊洛沙姆凝胶给药的动物实验及药动学研究
Soheil Tafazzoli Mehrjardi,Mohsen Tafaghodi,Davood Yari et al.
Soheil Tafazzoli Mehrjardi et al.
Intranasal drug delivery provides rapid absorption and high bioavailability while reducing systemic exposure, making it a hopeful route for nose-to-brain (N2B) transport. However, no effective N2B system has yet been systematically studied ...
Comparative Study
AAPS PharmSciTech. 2026 Jun 4;27(5):226. DOI:10.1208/s12249-026-03430-6 2026
Antibody-Drug Conjugates Drug Product Formulation and Process Development, Scalability and Stability Considerations [0.03%]
抗体偶联药物产品配方及工艺开发、放大和稳定性考虑因素
Léa Sorret,Mamiko Ninomiya,Nils Hillebrandt et al.
Léa Sorret et al.
Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the potency of cytotoxic small molecules, offering enhanced therapeutic potential. However, their inherent structural complexity, arising from the ...
Design of Ion-Pairing Azithromycin liposome for Local Pulmonary Delivery with Prolonged Lung Retention [0.03%]
一种新型大环内酯类抗生素偶离子阿奇霉素肺部给药脂质体及其设计制备和评价方法
Mengtong Wu,Siqi Li,Hongbing Liu et al.
Mengtong Wu et al.
Mycoplasma pneumoniae pneumonia (MPP) is a major cause of community-acquired pneumonia in children, and azithromycin (AZM) is recommended as a first-line macrolide for its treatment. However, current oral and intravenous AZM formulations re...
Carbohydrate-Functionalized Liposomal Nanocarriers: Design Strategies for Receptor-Mediated Organ Targeting and Advanced Theranostic Applications [0.03%]
基于碳水化合物的功能化脂质体纳米递药系统：受体介导的器官靶向及诊疗一体化应用的设计策略
Jayaraj Beliraya,Raagul Seenivasan,Praveen Halagali et al.
Jayaraj Beliraya et al.
Liposomes are among the most advanced drug-delivery technologies in modern nanomedicine, with high biocompatibility, structural diversity, and surface activity. They can carry both hydrophilic and lipophilic drugs. While they have been succ...
Safe Handling and Clinical Administration of Antibody Drug Conjugates: Occupational Safety, Material Compatibility, and the Integration of CSTDs into Workflows [0.03%]
抗体偶联药物的安全处理及临床给药：职业安全、材料相容性以及CSTD在工作流程中的整合
Lara Nonis,Yaser Alkhatib,Balasubramanian Sivakumar et al.
Lara Nonis et al.
Antibody-drug conjugates (ADCs) represent a rapidly expanding class of therapeutics, combining the specificity of monoclonal antibodies with the potency of cytotoxic payloads. Their increasing clinical adoption introduces complex challenges...
Comments on "Methodological Concern Regarding the In Vitro Release Assessment Performed Using a Dialysis Method with a PBS/ethanol (1:1, v/v) Medium" [0.03%]
对“关于使用PBS/乙醇（1：1，v/v）介质进行体外释放评价的质疑”一文的看法
Sophia Hatziantoniou
Sophia Hatziantoniou
Exploring Synergistic Potential of Sorafenib and Atorvastatin to Launch Apoptosis and Ferroptosis-driven Mixed Cell Death Mechanism in Colorectal Cancer [0.03%]
索拉非尼和阿托伐他汀协同启动结直肠癌细胞混合性死亡机制的潜在作用研究
Vivek Yadav,Sayali Dighe,Pratik Dhake et al.
Vivek Yadav et al.
Colorectal cancer (CRC) is a third leading cause of death and is often recognised by a higher mutation burden. The standard clinical regimen for CRC chiefly focuses on targeting a single-cell death mechanism, which encounters constraints su...
Understanding the Impact of Particle Size and Crystal Habit of Mesalamine Drug Substances on Their Packing, Wetting, and Dissolution Behaviour: A Science-based Approach for Selection of API Vendor [0.03%]
基于科学的选择活性药物成分供应商的方法来理解 mesalamine 药物实体的粒径和晶体形态对其包装，润湿以及溶解行为的影响
Prakash Kumar Sirvi,Ayush Rohila,Sakshi Kunjir et al.
Prakash Kumar Sirvi et al.
Solid-state pharmaceutical properties play a pivotal role in determining product performance, manufacturing consistency, and clinical outcomes, especially for high-dose active pharmaceutical ingredients (APIs). Mesalamine (MES), a BCS class...