In-situ Nanolipoidal Gel of Stiripentol for Intranasal Administration: Preclinical Evidence of Enhanced Biopharmaceutical and Therapeutic Outcomes [0.03%]
一种用于鼻腔给药的搅拌丙酮醇原位纳米脂质凝胶：增强生物药代动力学和治疗效果的临床前证据
Harshada Mahajan,Pradip Nirbhavane,Shailesh Chalikwar et al.
Harshada Mahajan et al.
Stiripentol (STP), an antiepileptic drug, is administered orally in the form of capsule and dry suspension. However, it is extremely unstable in acidic environment. Hence, to find the feasibility of alternate route of administration and to ...
LC-ESI-HRMS-Based Evaluation of Antioxidants as Additives to Inhibit Genotoxic Nitrosamine Formation in Metformin Hydrochloride Tablets [0.03%]
基于LC-ESI-HRMS的抗氧化剂评价及其作为抑制盐酸二甲双胍片中致癌亚硝胺形成的辅料性能研究
Aishwarya Dande,Nikhil Pallaprolu,Sangita Gadilohar et al.
Aishwarya Dande et al.
Nitrosamines, particularly N-nitrosodimethylamine (NDMA), have raised significant regulatory and safety concerns due to it's genotoxic and carcinogenic properties. Although NDMA formation in metformin hydrochloride (MET) tablets under nitro...
Stimuli-responsive Hydrogels for Targeted Antibiotic Delivery in Bone Tissue Engineering [0.03%]
用于骨组织工程的刺激响应性水凝胶控制抗生素递送以治疗生物膜感染
Jayendra Kumar,Tolepbergenova M,Abdugani Musayev et al.
Jayendra Kumar et al.
Bone tissue engineering (BTE) faces critical challenges in managing infections such as osteomyelitis, which complicate healing and compromise implant success. Conventional antibiotic therapies often fail to achieve effective localized drug ...
Micro-Flow Imaging: Enhanced Precision in Clarity Assessment of Traditional Chinese Medicine TCM Injections Compared to Light Obscuration and Visual Inspection [0.03%]
微流成像法：与激光散射和目视检查相比，在中药注射剂清晰度测定中可获得更高的精确度
Le Yang,Sijun Wu,Haibin Qu
Le Yang
This study explored the application of Micro-Flow Imaging (MFI) technology in detecting insoluble particles in traditional Chinese medicine (TCM) injections. Using Danshen Injection (DI) and Guanxinning Injection (GXNI) as examples, we veri...
Comparative Study
AAPS PharmSciTech. 2025 Aug 20;26(7):216. DOI:10.1208/s12249-025-03213-5 2025
Electromagnetic Field Influence on the Bioavailability and Accumulation of Ketoprofen [0.03%]
电磁场对ketoprofen生物利用度和积累的影响
Karolina Zyburtowicz-Ćwiartka,Anna Nowak,Anna Muzykiewicz-Szymańska et al.
Karolina Zyburtowicz-Ćwiartka et al.
The growing interest in transdermal drug delivery systems has led to the exploration of novel methods to enhance skin permeability and drug bioavailability. In this study, the effects of various electromagnetic fields (EMF) configurations o...
Correction: In Vivo Evaluation of Almotriptan Malate Formulation Through Intranasal Route for the Treatment of Migraine: Systematic Development and Pharmacokinetic Assessment [0.03%]
校正：评估艾司托普坦马来酸盐鼻用制剂治疗偏头痛的体内评价：系统开发和药代动力学评估
Shubham Gupta,Akhil Perla,Abhishek Roy et al.
Shubham Gupta et al.
Published Erratum
AAPS PharmSciTech. 2025 Aug 19;26(7):214. DOI:10.1208/s12249-025-03219-z 2025
Paloch Chinwattanawongwan,Narueporn Sutanthavibul,Oran Kittithreerapronchai
Paloch Chinwattanawongwan
The quality attributes of pharmaceutical products have been affected by the duration of manufacturing processes; therefore, manufacturers use various endpoint determination approaches such as time- and property-defined endpoints. In this st...
Palatable Orally Disintegrating Tablets of Losartan Potassium Developed by Spray-drying Technique and Direct Compression Intended for Pediatric Use [0.03%]
一种用于儿童的氯沙坦钾口崩片的制备工艺：喷雾干燥与直接压片法
Candela Juan,Noelia Gonzalez Vidal,Loreana Gallo
Candela Juan
Several diseases that affect the pediatric population, e.g., heart diseases, cannot be efficiently treated because of the absence of a suitable dosage form. In this sense, orally disintegrating tablets (ODT) are solid dosage forms that are ...
Development of a pH Gradient Dissolution Condition to Predict the Behavior of Delayed Release Formulations under Fed In Vivo Condition [0.03%]
一种用于预测延迟释放剂型在进食条件下的体内行为的pH梯度溶解方法的研究与发展
Juilee Kulkarni,Usha Nayak,Bibhuranjan Panigrahi et al.
Juilee Kulkarni et al.
To deliver Mesalamine (MSA) in the treatment of Ulcerative Colitis (UC) at the targeted site of action, numerous modified release formulations have been developed to release the drug in colon that are coated with pH dependent delayed releas...
Thermoreversible Ionogel for Enhanced Nose-to-brain Delivery of Tetrabenazine Hydrochloride: Optimization by Central Composite Design and In Vitro Ex Vivo Evaluation [0.03%]
基于星形复合设计优化的氯化四苯扎尼离子凝胶经鼻给药的研究及体内外评价
Namdeo Jadhav,Manali Chavan,Prathamesh Patil et al.
Namdeo Jadhav et al.
Bio-ionic liquid (BIL)-based ionogels have been researched for improved solubility, permeability, and bioavailability of poorly soluble drug/s. This study aimed to develop a thermoreversible ionogel for nose-to-brain delivery (NBD) of Tetra...