Twin-Screw Melt Granulation with Mannitol: High-Drug-Loaded Immediate-Release Tablets of Caffeine [0.03%]
以无水山梨糖醇为载体制备咖啡因熔融挤出颗粒及其速释片的研究
Elzbieta Maria Buczkowska,Kirils Kukuls,Zoltán Márk Horváth et al.
Elzbieta Maria Buczkowska et al.
High drug-loaded immediate-release formulations can be produced using a solvent-free and continuous melt-granulation method with a twin-screw extruder. Known and widely used high-molecular-weight and hydrophobic melt-binders result in weak ...
Chloramphenicol Application Onto the Eyelid: Transfersomes for Enhanced Skin Delivery [0.03%]
用于眼睑给药的氯霉素递释系统(membrane free transfersome)透皮吸收研究
Larysa Grygor&#x;yeva,Manuela Colla Carvalheiro,Joana Marto et al.
Larysa Grygor&#x;yeva et al.
The aim of the study was to prepare chloramphenicol (CAM)-loaded transfersomes to enhance drug permeability following topical administration, considering the final goal of treating conjunctivitis by applying the formulation onto the eyelid....
Correction: Carbohydrate-Functionalized Liposomal Nanocarriers: Design Strategies for Receptor-Mediated Organ Targeting and Advanced Theranostic Applications [0.03%]
碳水化合物修饰脂质体纳米载体：受体介导的器官靶向和先进诊疗应用的设计策略（纠错文章）
Jayaraj Beliraya,Raagul Seenivasan,Praveen Halagali et al.
Jayaraj Beliraya et al.
Published Erratum
AAPS PharmSciTech. 2026 Jun 11;27(5):237. DOI:10.1208/s12249-026-03483-7 2026
Development of Resveratrol/Curcumin Dual-Loaded Chitosan/Sericin Hydrogel Films for Wound Healing: A Comparison Of Shrimp- and Crab-Sourced Chitosan [0.03%]
用于伤口愈合的茋/姜黄素共载壳聚糖/丝素蛋白水凝胶膜的开发：虾和蟹来源的壳聚糖的比较
Bui Thi Phuong Thuy,Phuong T M Ha,Nguyen Thi Ngoc Quyen et al.
Bui Thi Phuong Thuy et al.
This study reports the formulation and comparative evaluation of resveratrol and curcumin dual-loaded chitosan-based wound-healing films prepared from shrimp-derived chitosan (Shrimp-CTS, ~ 80 kDa, degree of deacetylation of ~ 95%) and crab...
Comparative Study
AAPS PharmSciTech. 2026 Jun 10;27(5):235. DOI:10.1208/s12249-026-03475-7 2026
Solvent‑Free Bioerodible Ophthalmic Inserts for Mangiferin Delivery: Physicochemical Characterization and In Vivo Evaluation [0.03%]
一种不含溶剂的生物可降解递送缅茄茋的眼用插入剂：物理化学特性和体内评价
Nam V Dao,Tu V Le,Anh Q Vo
Nam V Dao
Ophthalmic topical dosage forms are often limited by their low bioavailability, primarily due to rapid precorneal clearance. Prolonging the precorneal residence time enables sufficient drug absorption and facilitates the desired pharmacolog...
Brian O&#x;Mara,Shantanu Guha
Brian O&#x;Mara
Antibody-drug conjugates (ADCs) combine the targeting specificity of monoclonal antibodies with cytotoxic small-molecule payloads, enabling selective delivery of highly potent therapeutics. As the field has advanced, conjugation strategy ha...
Amphotericin B-cholesterol Co-encapsulated Polymeric Nanoparticles in Protein Hydrogel-based Injectable Depot System for Long-acting Drug Delivery [0.03%]
一种基于蛋白质水凝胶的可注射药物递送系统用于包封两性霉素B-胆固醇共包裹聚合物纳米颗粒长期给药研究
Sanat Kumar Dash,Rashmi Ghosh,Anil B Jindal
Sanat Kumar Dash
Amphotericin B exhibits dose-dependent nephrotoxicity and hepatotoxicity due to its non-selective interaction with mammalian cholesterol. The aim of the present study was to develop an Amphotericin B-cholesterol co-encapsulated albumin hydr...
Oil-in-water Emulsion as a Strategy for Taste Masking of Cannabinoid Extract [0.03%]
水包油乳剂作为大麻提取物掩味策略的研究
Juliana Feitoza Brasil,Luiza Aparecida Luna Silvério,Claudete da Costa-Oliveira et al.
Juliana Feitoza Brasil et al.
Organoleptic properties are important factors in the development of pharmaceutical formulations, as they directly impact patient adherence and, consequently, treatment efficacy. Cannabinoid-based oils often possess unpleasant taste and text...
Rapid Identification of Counterfeit Biopharmaceuticals using Portable Fourier Transform Infrared Spectroscopy [0.03%]
基于便携式傅里叶变换红外光谱法的生物药物快速鉴别方法
Vineela Peruri,Rishika Trivedi,Drashti Trivedi et al.
Vineela Peruri et al.
Biopharmaceuticals are expensive due to their sophisticated manufacturing processes, challenges in analytical characterization, and stringent storage and transportation conditions. Due to the high cost and increasing demand, they have emerg...
Matrix Metalloproteinase-9-Responsive Lipid-Core Micelles for Proof-of-Concept Enzyme-Triggered Cardiomyocyte Association [0.03%]
一种用于概念验证的酶触发心肌细胞结合的基质金属蛋白酶9响应型脂核胶束
Wai-Houng Chou,Jafet Ortiz-Quintero,Sergio Bedoya et al.
Wai-Houng Chou et al.
Cardiovascular diseases (CVDs) remain the leading cause of global mortality and are frequently associated with increased matrix metalloproteinase-9 (MMP-9) activity during cardiac remodeling and inflammation. Here, we developed lipid-core m...