The Preparation and Physicochemical Characterization of a Triple Synergistic Nanoplatform Designed for Targeted Subcutaneous Delivery of Sitagliptin with Potential for β-Cell Preservation [0.03%]
一种用于西他列汀皮下靶向递送并具有潜在β细胞保护作用的三重协同纳米平台的设计、制备及理化性质研究
Mo&#x;tasem M Alsmadi,Rana Obaidat
Mo&#x;tasem M Alsmadi
Effective diabetes management necessitates innovative strategies that simultaneously stimulate β-cell growth and prevent apoptosis. While sitagliptin is an established therapeutic, its clinical utility is often hampered by suboptimal oral ...
Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation [0.03%]
基于纳米载体的非抗肿瘤药物再利用用于癌症治疗：机制、协同组合和临床转化
Nur Aininie Yusoh,Afiq Azil,Ahlam Zaid Alkilani et al.
Nur Aininie Yusoh et al.
The urgent need for innovative cancer therapies has driven increasing interest in repurposing drugs originally developed for non-oncological diseases. Several FDA-approved and clinically investigated agents, including mesalamine, celecoxib,...
Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin [0.03%]
通过战略性选择含硫配体来制备新型二甲双胍共晶以克服渗透障碍
Mangesh R Bhalekar,Ashwini R Madgulkar,Shweta J Khiratkar
Mangesh R Bhalekar
Metformin, a BCS Class III drug, is limited by poor intestinal permeability despite high solubility, affecting its bioavailability. This study aimed to enhance Metformin's permeability via cocrystallization with functional coformers. L-Cyst...
Plume Geometry Matters: Investigating the Contribution of Mass-Based Plume Geometry to Aerosol Delivery Efficiency in pMDIs [0.03%]
气溶胶几何形状影响干粉吸入剂的输送效率研究
Daniel Moraga-Espinoza,Eli Eshaghian,Tania F Bahamondez-Canas et al.
Daniel Moraga-Espinoza et al.
To improve the performance of pressurized metered dose inhalers (pMDIs) a better mechanistic understanding of early deposition within the device and upper airways is needed to move toward more efficient inhalation therapies. The present wor...
Eigenrate-Based Thermodynamic Decomposition of Competing Release Mechanisms in Polymeric Nano- and Microspheres: The MMIR-S Framework with Arrhenius Dual-Population Burst Kinetics and Log-Normal Polydispersity Averaging [0.03%]
基于特征释放速率的动力学拆分聚合物纳米球和微球中竞争的药物释放机制：具有Arrhenius双群体burst动力学模型和Log-正态分布多分散性平均效应的MMIR-S框架
Pitt Supaphol
Pitt Supaphol
Simultaneous operation of Fickian diffusion, swelling-mediated relaxation, and polymer erosion in polymeric nano- and microspheres produces release profiles whose mechanistic origins cannot be resolved by empirical models without system-spe...
Charge-Interaction-Mediated Adsorption of Human Growth Hormone on Polymeric Nanoparticles [0.03%]
多聚物纳米颗粒介导的人类生长激素吸附的电荷作用机制研究
Rajeshwar Motheram,Rijo John,Jasmin Monpara et al.
Rajeshwar Motheram et al.
The adsorption behavior of recombinant human growth hormone (r-hGH) on cationic (PS+, amidine) and anionic (PS-, sulfate) polystyrene surfaces was investigated under varying solution pH conditions (surface charge), ionic strengths (0.0075 M...
Development and Characterization of Amorphous PVP K30-Phosphatidylcholine Dispersions for the Fixed-Dose Co-Delivery of Hesperetin and Cannabidiol Prepared by Hot-Melt Extrusion [0.03%]
用于固定剂量共递送hesperetin和cannabidiol的聚维酮K30-卵磷脂无定形分散体的制备及特征描述（热熔挤出法制备）
Kamil Wdowiak,Judyta Cielecka-Piontek
Kamil Wdowiak
Hesperetin and cannabidiol (CBD) are promising plant-derived bioactives whose oral performance is limited by poor aqueous solubility. To address the shared biopharmaceutical limitations of both compounds, amorphous PVP K30-phosphatidylcholi...
In Vitro Release Prediction of Colchicine Transdermal Patch Based on Raman Spectroscopy Imaging and Data-Driven Modeling [0.03%]
基于拉曼光谱成像和数据驱动建模的秋水仙碱贴片体外经皮释放行为预测研究
Xin Sha,Wenliang Dong,Lisong Zhang et al.
Xin Sha et al.
This study explored the feasibility of combining Raman spectroscopic imaging with data-driven modeling for estimating colchicine release from transdermal patches under in vitro conditions, aiming to reduce the operational complexity and lon...
Samson Gebretnsae
Samson Gebretnsae
Antibody-drug conjugates (ADCs) are a therapeutic approach that embodies the "magic bullet" concept envisioned by Paul Ehrlich. Since their initial clinical potential was recognized in the early 1980s, ADCs have undergone several generation...
SeDeM-Guided Design and Optimization of MCC-Calcium Sulfate Co-Processed Excipient (MCCASUL) for Direct Compression Applications [0.03%]
基于SeDeM的一站式设计与优化直接压片用微晶纤维素-硫酸钙共处理辅料(MCCASUL)
Minal R Narkhede,Sonal Y Mhaske
Minal R Narkhede
Direct compression is a generally preferred for tablet manufacturing method. However, it demands excipients with balanced flowability, compressibility, and packing properties. Microcrystalline cellulose (MCC) and calcium sulphate (CaSO₄) h...