Phospholipid Complexation for Bioavailability Improvement of Albendazole: Preparation, Characterization and In Vivo Evaluation [0.03%]
albendazole磷脂复合物的制备、表征和体内实验研究提高药物吸收率
Liyao Liu,Jinju Nie,Letao Li
Liyao Liu
The current study aimed to improve the poor solubility of albendazole (ABZ) by means of phospholipid complexation, hence to improve its oral bioavailability. The solvent-evaporation method for ABZ-phospholipid complex (ABZ-PC) preparation w...
Modeling Approaches to Reimagine Stability (MARS) for Enabling Earlier Access to Critical Drugs for Patients with Unmet Medical Needs [0.03%]
为满足未竟医疗需求的患者更早地提供关键药物而重新构想稳定性的方法（MARS）模型途径
M Scott Furness,Hong Cai,Sithamalli Chandramouli et al.
M Scott Furness et al.
FDA's experience to date has shown that completion of stability data requirements is one of the most observed challenges for applicants of New Drug Applications (NDAs) with an expedited review designation. Since NDAs submitted under these e...
Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies [0.03%]
青蒿琥酯的热稳定性和水解稳定性及水中溶解度评价用于剂型研究
J W Bezuidenhout,M Aucamp,N Stieger et al.
J W Bezuidenhout et al.
For the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability and solubility prof...
In Vivo Evaluation of Almotriptan malate Formulation through Intranasal Route for the Treatment of Migraine: Systematic Development and Pharmacokinetic Assessment [0.03%]
苹果酸阿洛西坦鼻腔给药制剂的体内评价：系统开发和药代动力学评估
Shubham Gupta,Akhil Perla,Abhishek Roy et al.
Shubham Gupta et al.
Migraine headaches are usually intolerable, and a quick-relief treatment remains an unmet medical need. Almotriptan malate is a serotonin (5-HT1B/1D) receptor agonist approved for the treatment of acute migraine in adults. It is currently a...
Machine Learning-Enabled NIR Spectroscopy. Part 2: Workflow for Selecting a Subset of Samples from Publicly Accessible Data [0.03%]
机器学习增强的近红外光谱技术。第2部分：从公共数据中选择样本子集的工作流程
Hussain Ali,Prakash Muthudoss,Manikandan Ramalingam et al.
Hussain Ali et al.
An increasingly large dataset of pharmaceutics disciplines is frequently challenging to comprehend. Since machine learning needs high-quality data sets, the open-source dataset can be a place to start. This work presents a systematic method...
Experimental Evaluation of the Impact of Rapid Environmental Changes on Stress Distribution in Tablet Coatings [0.03%]
快速环境变化对药片涂层应力分布影响的实验评估
Krishnayan Haldar,Mahesh S Tirumkudulu,Ashwin Jain et al.
Krishnayan Haldar et al.
Drying-induced cracks in tablet coatings are undesirable as they not only affect tablet's appearance, but they may also interfere with its function. While it is well known that tensile stresses in the coating are responsible for coating fai...
Processability and Oral Bioavailability Improvement of Itraconazole by Particle Engineering Technique [0.03%]
通过粒子工程学技术改善伊曲康唑的可加工性和口服生物利用度
Hiral Kapalatiya,Dhrumi Patel,Alok D Singh et al.
Hiral Kapalatiya et al.
The current study aimed to improve the processability and oral bioavailability of itraconazole (ITZ) via spherical agglomeration. ITZ-spherical agglomerates (ITZ-SA) and ITZ-poloxamer 407-spherical agglomerates (ITZ-PLX-SA) were optimized u...
Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect [0.03%]
基于延长肠道滞留时间、提高生物利用度和降血糖效应的盐酸二甲双胍黏膜纳米粒肠溶胶囊
Wenjie Lu,Lingfei Yu,Lujun Wang et al.
Wenjie Lu et al.
Metformin hydrochloride enteric-coated capsule (MH-EC) is a commonly used clinical drug for the treatment of type 2 diabetes. In this study, we described a metformin hydrochloride mucosal nanoparticles enteric-coated capsule (MH-MNPs-EC) ba...
Impact of Properties of Hydrated Silicon Dioxide as Core Material on the Characteristics of Drug-containing Particles Prepared by the 2-step Process Melt Granulation Technology, MALCORE® [0.03%]
作为芯材的水合二氧化硅的性质对两步法熔融造粒技术MALCORE®制备载药颗粒特性的影响
Ryota Kimata,Naoki Yoshihara,Takayuki Terukina et al.
Ryota Kimata et al.
Drug-containing particles (DCPs) are frequently used as cores in the development of solid oral dosage forms. The wet layering technique, which is a typical approach for preparing DCPs, requires the use of solvents and a long manufacturing t...
Film-Forming Properties of Topical Formulations for Skin and Hair: In Vivo and In Vitro Studies Using Biophysical and Imaging Techniques [0.03%]
皮肤和头发外用制剂的成膜性能：采用生物物理和成像技术进行的体内体外研究
Victor Hugo Pacagnelli Infante,Marcella Gabarra Almeida Leite,Patrícia M B G Maia Campos
Victor Hugo Pacagnelli Infante
The film-forming effect is an important property of formulations for skin improvement and hair protection. Reflectance confocal microscopy, an advanced imaging technique, is an important tool for its evaluation. Thus, the aim of this study ...