Continuous Manufacturing of Controlled-Release Metoprolol Succinate Tablets by Novel Hot-Melt Fragmentation Technology [0.03%]
连续制造控释美托洛尔琥珀酸盐片的新型热熔断片技术
Rajat Radhakrishna Rao,Naitik Jain,Vinay Rao et al.
Rajat Radhakrishna Rao et al.
A novel metoprolol succinate tablet-in-tablet-in-tablet system was developed using hot-melt granulation combined with twin-screw continuous processing to provide an accurate 24-h sustained release. Tablet-in-tablet-in-tablet system was opti...
Enhancing Doxorubicin Bioavailability via Dissolving Microneedles: Roles of Drug Loading and Administration Force [0.03%]
通过溶解型微针提高多柔比星生物利用度：药物载药量及穿刺力的作用
Beibei Yang,Huanhuan Pan,Chunxian Zhou et al.
Beibei Yang et al.
To mitigate the severe adverse effects associated with the systemic administration of doxorubicin (DOX), this study developed a dissolving microneedles (MN) patch loaded with doxorubicin hydrochloride (DOX-MN) for the local treatment of bre...
Srishty Jaiswal,Mitali Sethi,Rafquat Rana et al.
Srishty Jaiswal et al.
Extracellular vesicles, including exosomes, are naturally produced by various cell types both in vivo and in vitro. These nanovesicles, composed of a lipid bilayer, proteins, and RNAs, play a pivotal role in intercellular communication. The...
From Liquid to Solid: Formulation and Characterization of Testosterone-Loaded S-SMEDDS Pellets Using a 24 Factorial Design [0.03%]
从液态到固态：使用24因素实验设计制备和表征含睾丸素的S-SMEDDS微丸
Ohary de Sousa Borges,Julia Ornelas Kramer,Henrique Pascoa et al.
Ohary de Sousa Borges et al.
The solidification of self-microemulsifying drug delivery systems (SMEDDS) represents a significant advance in the transition from self-microemulsifying technology to industrial-scale production. A solid self-microemulsifying drug delivery ...
Advances in Nanoparticle-Based Vitamin Delivery Systems for Precision Nutrition and Improved Bioavailability [0.03%]
基于纳米粒子的维生素输送系统在精准营养和改善生物利用度方面的进展
Sathvik Chennamsetty,Mahesha Keerikkadu,Akshay Shetty et al.
Sathvik Chennamsetty et al.
Deficiencies of vitamins D, A, E, K, B12, and Folate remain a significant public health concern, even with the broad implementation of supplementation efforts. Traditional oral vitamin formulations have low bioavailability due to poor water...
Methodological Concern Regarding the In Vitro Release Assessment Performed Using a Dialysis Method with a PBS/ethanol (1:1, v/v) Medium [0.03%]
有关使用PBS/乙醇（1：1，v/v）透析法进行体外释放实验的方法学问题的探讨
Sophia G Antimisiaris
Sophia G Antimisiaris
Design and Development of Prolong-acting Intelligent Nano-depot (PaIND) for Improving Patient Adherence [0.03%]
长效智能纳米仓(PaIND)的设计与开发以改善患者依从性
Hardik Rana,Shreya Gohel,Prachi Rabari et al.
Hardik Rana et al.
Medication adherence is a major limitation in the current era. The purpose of the current research was to develop a Prolong-acting intelligent nano-depot (PaIND) for patients diagnosed with hypercholesterolemia, utilizing Rosuvastatin (RSV)...
3D Printed Vaginal Rings For Contraceptive Applications: Materials, Mechanisms, and Opportunities [0.03%]
用于避孕应用的3D打印阴道环：材料、机制和机遇
Riya Patel,Paranshi Jadeja,Shailvi Shah et al.
Riya Patel et al.
Despite the wide range of contraception options available, half of births worldwide are still unplanned. Intravaginal rings (IVRs) have been a popular method for delivering long-acting contraceptive drugs because they provide consistent hor...
Microneedle-Assisted Delivery of Biologics: From Large Molecules to Cancer Vaccines [0.03%]
用于生物制品递送的微针：从大分子到癌症疫苗
Salma Younas,Mohit Kumar,Ramsha Khalid et al.
Salma Younas et al.
Peptide- and protein-based biologics, including therapeutic peptides, monoclonal antibodies, and vaccines, have transformed modern therapeutics. However, they remain constrained by poor oral bioavailability, stability challenges, cold-chain...
Formulation and Characterization of Amisulpride-Poly (Lactic-Co-Glycolic Acid) Nanoparticles Coated with Chitosan for Intranasal Delivery [0.03%]
用于鼻内给药的氨磺必利-聚乳酸-co-羟基乙酸纳米颗粒的制备及其壳聚糖包覆性能研究
Mai S Khanfar,Sumieh Y Alaboud,Raida W Khalil et al.
Mai S Khanfar et al.
Amisulpride effectively treats both positive and negative symptoms of schizophrenia. However, its poor aqueous solubility and low intestinal permeability limit oral bioavailability. This study developed chitosan-coated poly(lactic-co-glycol...