Gregory M Alushin,Sarah M Connolly,Blessing C Njoku
Gregory M Alushin
Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding proteins. The cytoskeleton plays a central...
Andrea Rocha,Alan Saghatelian
Andrea Rocha
Small proteins, known as microproteins, typically consisting of fewer than 150 amino acids, have recently emerged as a previously unrecognized class of functional genes in biology. Advances in ribosome profiling, proteogenomics, and genome-...
Epigenetic Inheritance Through Replication-Coupled Parental Histone Recycling [0.03%]
与复制偶联的父母组蛋白循环再利用的表观遗传传递
Juntao Yu,Danesh Moazed
Juntao Yu
Epigenetic inheritance of repressed chromatin domains plays a central role in the stable silencing of cell type-specific genes and transposons in eukaryotes. Silent chromatin domains are associated with repressive histone modifications, and...
Ryoichiro Kageyama,Akihiro Isomura
Ryoichiro Kageyama
Both the levels and duration of gene expression play critical roles in many biological processes. Recent studies have further revealed that the dynamics of oscillatory versus sustained gene expression also provide essential regulatory infor...
Hao Lu,Govind Yadav,Sudipto Roy
Hao Lu
It is believed that the last common eukaryotic ancestor was a ciliated organism that used cilia for locomotion and sensation. Many extant ciliated protozoans exemplify this archetypal condition. However, in metazoans, particularly vertebrat...
Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in the Arabidopsis thaliana Root Meristem [0.03%]
《循环于根中——拟南芥根分生组织细胞周期运转的发育调控》
Anna T DiBattista,Laura R Lee,Zachary L Nimchuk
Anna T DiBattista
A plant's indeterminate growth requires constant cell proliferation and stem cell maintenance to support its developmental plasticity. The root meristem is an excellent system to study the developmental control of plant cell cycles due to t...
Martine Cohen-Salmon
Martine Cohen-Salmon
Local protein synthesis is a conserved mechanism that allows cells with intricate architectures to perform compartment-specific functions. By translating messenger RNAs (mRNAs) at distinct subcellular locations, cells can respond swiftly an...
Shubha Tole,Anasua Mandal,Amrita Singh
Shubha Tole
The hippocampus is critical for an array of cognitive functions arising from its complex substructure and connectivity. Important insights into hippocampal field specification emerged from classical studies that examined mice lacking partic...
Regulation of Hematopoietic Stem Cell Dormancy and Quiescence: Insights into Regeneration and Disease [0.03%]
造血干细胞休眠和静息的调控：再生与疾病的启示
Jasmin Rettkowski,Nina Cabezas-Wallscheid
Jasmin Rettkowski
Stem cells are undifferentiated cells capable of self-renewal and differentiation into specialized cell types, forming the foundation of tissue maintenance and repair. In the blood system, this process is known as hematopoiesis. Hematopoiet...
Rupert Faraway,Daniel Zenklusen,Clemens Plaschka
Rupert Faraway
The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs are packaged by proteins into mRNA ribonuc...