Shubha Tole,Anasua Mandal,Amrita Singh
Shubha Tole
The hippocampus is critical for an array of cognitive functions arising from its complex substructure and connectivity. Important insights into hippocampal field specification emerged from classical studies that examined mice lacking partic...
Regulation of Hematopoietic Stem Cell Dormancy and Quiescence: Insights into Regeneration and Disease [0.03%]
造血干细胞休眠和静息的调控：再生与疾病的启示
Jasmin Rettkowski,Nina Cabezas-Wallscheid
Jasmin Rettkowski
Stem cells are undifferentiated cells capable of self-renewal and differentiation into specialized cell types, forming the foundation of tissue maintenance and repair. In the blood system, this process is known as hematopoiesis. Hematopoiet...
Rupert Faraway,Daniel Zenklusen,Clemens Plaschka
Rupert Faraway
The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs are packaged by proteins into mRNA ribonuc...
Gene Clusters Reveal Fundamental Principles of Genome Folding and Transcriptional Regulation [0.03%]
基因簇揭示了基因组折叠和转录调控的基本原理
Alex Buckley,Carlo Vetralla,Daniele Canzio
Alex Buckley
Gene clusters generate proteome diversity required for cell fate and function. Given their genomic organization, wherein tandemly arranged genes with nearly identical promoter sequences neighbor shared enhancers, gene clusters present extre...
Kai Weißenbruch,Roberto Mayor
Kai Weißenbruch
The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from streams with hundreds of cells delaminati...
Custodio O Nunes,Elias H Barriga
Custodio O Nunes
Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities influence single-cell and collective cell b...
Zebrafish Gastrulation [0.03%]
斑马鱼原肠运动
Miguel L Concha
Miguel L Concha
The primordial body architecture of vertebrates is established during gastrulation, a critical period of development characterized by the emergence of the three germ layers (ectoderm, mesoderm, and endoderm) and the formation of an embryo w...
Protein Storage in Oocytes: Implications for Oocyte Quality, Embryonic Development, and Female Fertility [0.03%]
卵子中蛋白质的储存：对卵子质量、胚胎发育和女性生育力的影响
Ida Marie Astad Jentoft,Melina Schuh
Ida Marie Astad Jentoft
Maternal storage is a fundamental feature of female gametes and is essential for maintaining oocyte quality and preserving developmental competence. Embryonic development relies on maternally deposited proteins, transcripts, and nutrients, ...
Tamara Zünd,Viola Vogel,Enrico Klotzsch
Tamara Zünd
Immune cells possess a remarkable set of complementary surface protrusions, such as microvilli, podosomes, filopodia, and lamellipodia, which play pivotal roles in the sensing of and responding to varied environmental cues. These dynamic st...
Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development [0.03%]
节间信号传导：胚胎发育中TGFβ信号转导的范例
Jakob El Kholtei,Mireia Codina-Tobias,Alexander F Schier
Jakob El Kholtei
Nodal signaling molecules are TGFβ family ligands that arose early during bilaterian evolution and are crucial for several key steps in embryonic development. They regulate the specification of mesoderm and endoderm, body patterning, left-...