Li Yang,Jeremy E Wilusz,Ling-Ling Chen
Li Yang
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent transcriptomic studies have surprisingly unc...
Erik McShane,Matthias Selbach
Erik McShane
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial d...
Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence [0.03%]
真核细胞的大小调控及其与生物合成和衰老的关系
Shicong Xie,Matthew Swaffer,Jan M Skotheim
Shicong Xie
The most fundamental feature of cellular form is size, which sets the scale of all cell biological processes. Growth, form, and function are all necessarily linked in cell biology, but we often do not understand the underlying molecular mec...
Tony Y-C Tsai,Rikki M Garner,Sean G Megason
Tony Y-C Tsai
Since the proposal of the differential adhesion hypothesis, scientists have been fascinated by how cell adhesion mediates cellular self-organization to form spatial patterns during development. The search for molecular tool kits with homoph...
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues [0.03%]
细胞和组织中的时空图案的机械化学原理
Anaïs Bailles,Emily W Gehrels,Thomas Lecuit
Anaïs Bailles
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. Mathematical frameworks have been devised to account for the self-organization of biological patterns, most famously the Turing ...
Guangshuo Ou,Jonathan M Scholey
Guangshuo Ou
Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that consecutively assemble and disassemble during interphase and M phase of the cell cycle, respectively, and play fundamental roles in how eukaryotic cells swi...
Alex Willems,Lieven De Veylder
Alex Willems
The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them...
A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity [0.03%]
三个系统的寓言：肥胖的神经免疫内分泌模型研究中的进展
Conan J O O&#x;Brien,Emma R Haberman,Ana I Domingos
Conan J O O&#x;Brien
The prevalence of obesity is on the rise. What was once considered a simple disease of energy imbalance is now recognized as a complex condition perpetuated by neuro- and immunopathologies. In this review, we summarize the current knowledge...
Ruth Lehmann
Ruth Lehmann
Molecular Mechanisms of Sexually Dimorphic Nervous System Patterning in Flies and Worms [0.03%]
果蝇和线虫中性别二态性神经系统模式的分子机制
Stephen F Goodwin,Oliver Hobert
Stephen F Goodwin
Male and female brains display anatomical and functional differences. Such differences are observed in species across the animal kingdom, including humans, but have been particularly well-studied in two classic animal model systems, the fru...