Engineered hydrogels for gastrointestinal therapeutics: Preclinical breakthroughs and clinical translation barriers [0.03%]
胃肠药物输送用工程水凝胶：临床前突破与临床转化障碍
Peng-Wei Xu,Miao Yu,Zheng-Han Xiao et al.
Peng-Wei Xu et al.
Hydrogels are widely regarded as pivotal biomaterials in modern biomedical applications. Their excellent biocompatibility, controllable degradation rates, and responsiveness to environmental stimuli make them especially valuable in the deve...
Biodegradable poly(CL-co-TOSUO)/curcumin membrane: Biocompatibility and IL-6 suppression in atherosclerosis-relevant macrophage inflammation [0.03%]
可降解聚(CL-co-TOSUO)/姜黄素膜：与动脉粥样硬化相关的巨噬细胞炎症中的生物相容性及IL-6抑制作用
Dongping Chen,Qingfa Liu,Lu Yang et al.
Dongping Chen et al.
Atherosclerotic plaque instability, driven by macrophage-derived foam cells and exacerbated by interleukin-6 (IL-6), necessitates localized anti-inflammatory strategies. To address this, we developed curcumin-loaded poly(ε-caprolactone-co-...
Advances in the management of ocular anterior segment diseases using biomaterials-based drug delivery systems [0.03%]
基于生物材料的药物输送系统在眼部前段疾病管理中的新进展
Nayana E Subhash,Meghana Prabhu,Manali Hazarika et al.
Nayana E Subhash et al.
The eye is an essential sense organ and drug delivery to the eye is a challenging task due to protective barriers that hinder drug penetration. Over 90 percent of treatments for eye diseases are topical, but frequent administration over ext...
Investigation of calvarial bone regeneration in a rat model using three-dimensional polycaprolactone/carboxymethyl chitosan nano composite scaffolds containing hydroxyapatite nanoparticles along with the icariin and atorvastatin synthesized by the freeze-casting method [0.03%]
采用冰铸法制备的含有多羟基磷灰石纳米颗粒的三维聚己内酯/羧甲基壳聚糖纳米复合支架结合淫羊藿素和阿托伐他汀修复大鼠颅骨缺损的研究
Nadia Sadeghi,Fereshteh Shanei,Abouzar Moradi et al.
Nadia Sadeghi et al.
Although autografts and allografts remain common for bone defect repair, they entail donor-site morbidity, limited availability, and potential immune rejection. The development of tissue engineering has provided a potential solution to over...
In vitro, ex vivo, and in vivo evaluation of polysaccharide based thermo-sensitive in situ gel for the treatment of glaucoma [0.03%]
基于多糖的眼用温敏原位凝胶的体外、体表及兔眼降压效果评价研究
Sonali Mandal,Nihar Ranjan Das,Kaushik Mukherjee et al.
Sonali Mandal et al.
One of the disadvantages of traditional ophthalmic formulations is their short residence time in the eye. An in situ gel is recommended as a remedy, as it can be converted into a gel upon contact with the eye and adhere for an extended peri...
A novel 3D-printed silk fibroin/hydroxypropyl methyl cellulose scaffold with good biocompatibility and controllable degradation in vivo [0.03%]
一种具有良好的生物相容性和可控制降解性的新型三维打印丝素/羟丙基甲基纤维素支架
Nongping Zhong,Liuxue Du,Yelong Bai et al.
Nongping Zhong et al.
In this study, novel silk (SF)-fibroin based scaffolds were fabricated via 3D printing of a thixotropic SF/hydroxypropyl methyl cellulose (HPMC) hydrogel. Two different concentrations of 3D printed SF/HPMC scaffolds (20 wt% and 30 wt%) were...
Study on fabrication of calcium sulfate hemihydrate/tricalcium phosphate based injectable bone cement modified by sodium alginate-carboxymethyl chitosan gel network and its resistance to collapse [0.03%]
基于海藻酸钠-羧甲基壳聚糖凝胶网络的硫酸钙半水合物/三钙磷酸盐骨水泥的制备及其防塌性能研究
Junjia Kang,Xiaojie Lian,Zhimin He et al.
Junjia Kang et al.
The collapsibility of bone cement may cause blood vessel embolism, blocking blood flow and causing serious complications such as pulmonary embolism or spinal cord injury, especially when implantation by injection. Therefore, it is of great ...
Reduced thermal damage with electrical conductive hydrogel in radiofrequency (RF)-induced intestinal fusion [0.03%]
导电水凝胶减少射频(rf)诱导肠粘连的热损伤
Zhongxin Hu,Lin Mao,Xuyan Liu et al.
Zhongxin Hu et al.
Radiofrequency (RF)-induced tissue thermal fusion is an innovative method of tissue anastomosis without the need for sutures or staples. However, this technology is generally challenged by significant tissue thermal damage, which may cause ...