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Pathology Education for Undergraduate and Graduate Students: It's Not just for Clinical Trainees [0.03%]
Avrum I Gotlieb,Richard N Mitchell Avrum I Gotlieb
Hepatoma-derived growth factor promotes liver carcinogenesis by inducing phosphatase and tensin homolog inactivation [0.03%]
Shih-Ming Yang,Tsung-Hui Hu,Jian Ching-Wu et al. Shih-Ming Yang et al.
Hepatoma-derived growth factor (HDGF) is located on chromosome 1q21-23, a locus frequently amplified in hepatocellular carcinoma (HCC), and has been proposed as an oncogenic factor by stimulating PI3K/Akt signaling. Phosphatase and tensin h...
Clinico-pathological characteristics of a distinct tumor phenotype: invasive lobular carcinoma with tubular elements (ILC-TE) in the WSG ADAPTcycle trial [0.03%]
Martin Radner,Sandy Burmeister,Katarzyna Jóźwiak et al. Martin Radner et al.
Background: Invasive lobular carcinoma with tubular elements (ILC-TE) is a recently identified variant of invasive lobular breast carcinoma (ILC). The histology of ILC-TE is defined by non-cohesive carcinoma cells mixed w...
Development of a technique for diagnosis and screening of superficial bladder cancer by cell-pellet DNA from urine sample [0.03%]
Jaekwon Seok,Hee Jeong Kwak,Chan-Koo Kang et al. Jaekwon Seok et al.
Bladder cancer (BCa) is the most common malignancy of the urinary system with high incidence and recurrence rates. There are several ways to detect BCa. However, different approaches have different accuracy, which essentially depends on the...
PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation [0.03%]
Rui Fang,Tuulia Vallius,Arianna Zhang et al. Rui Fang et al.
Preferentially Expressed Antigen in Melanoma (PRAME) and Ten-Eleven Translocation (TET) dioxygenase-mediated 5-hydroxymethylcytosine (5hmC) are emerging melanoma biomarkers. We observed an inverse correlation between PRAME expression and 5h...
AI-assisted detection of breast cancer lymph node metastases in the post-neoadjuvant treatment setting [0.03%]
Tony Xu,Dina Bassiouny,Chetan Srinidhi et al. Tony Xu et al.
Lymph node assessment for metastasis is a common, time-consuming, and potentially error prone pathologist task. Past studies have proposed deep learning (DL) algorithms designed to automate this task. However, none have explicitly evaluated...
Corrigendum to "MiR-181b suppresses angiogenesis by directly targeting cellular communication network factor 1" (Lab Invest 2021 Aug;101(8):1026-1035) [0.03%]
Yue Li,Siyuan Fan,Weichang Xia et al. Yue Li et al.
Q15.12024 Published Erratum Laboratory investigation; a journal of technical methods and pathology. 2025 Feb 26;105(4):104108. DOI:10.1016/j.labinv.2025.104108 2025
Roles for androgen receptor, ADAR2, and PD-L1 in primary urothelial carcinoma in situ of the bladder treated with Bacillus Calmette-Guérin therapy [0.03%]
Gabriele Ricciardi,Vincenzo Fiorentino,Francesco Pierconti et al. Gabriele Ricciardi et al.
In this retrospective observational multicenter study, we identified tumors and immune markers that are related to each other, which could help in selecting bladder primary urothelial carcinoma in situ (CIS) patients who respond better to B...
An optimized NGS Protocol for Detecting De Novo MET Amplification in NSCLC: Prognostic and Therapeutic Implications [0.03%] 检测非小细胞肺癌中De Novo MET扩增的优化NGS方案：预后和治疗意义
Simon Cabello-Aguilar,Julie A Vendrell,Solène Evrard et al. Simon Cabello-Aguilar et al.
MET amplification (METamp) is a noteworthy genomic alteration that can occur in patients with non-small cell lung cancer (NSCLC). It has been demonstrated to occur as a primary oncogenic driver that may exist prior to any treatment and is r...
Clinical Utility of Liquid-based Comprehensive Genomic Profiling (CGP) in Gastrointestinal Stromal Tumors (GIST) [0.03%] 基于液体的综合基因组图谱（CGP）在胃肠道间质瘤（GIST）中的临床应用
Hiba Mechahougui,Lindsey Hildebrand,James Haberberger et al. Hiba Mechahougui et al.
Treatment for GIST focuses on tyrosine kinase inhibitors (TKI), whose selection depends on specific mutations. We sought to determine the clinical utility of liquid biopsy in advanced GIST. Liquid (n=181) (FoundationOne®Liquid CDx) and tis...