Real World Evaluation of AI-Based Tumor Cell Content Quantification for Molecular Tumor Profiling [0.03%]
基于人工智能的肿瘤细胞含量量化在分子肿瘤谱分析中的真实世界评估研究
Mariam Gachechiladze,Jan-Niklas Runge,Tobias Kull et al.
Mariam Gachechiladze et al.
Purpose: Repeated evidence demonstrates limited reproducibility and accuracy of the visual quantification (VQ) of the tumor cell content (TCC) by clinical pathologists for downstream molecular testing. Artificial intellig...
Profiling Dectin-2-Positive Tumor-Associated Macrophages Across Human Cancers by Immunohistochemistry [0.03%]
人癌症中通过免疫组化技术对Dectin-2阳性肿瘤相关巨噬细胞的特征分析
Jason Ptacek,Tracey Lin,Bharathi Vennapusa et al.
Jason Ptacek et al.
Purpose: To characterize the prevalence and distribution of Dectin-2-positive macrophages across human tumors and develop a research immunohistochemistry (IHC) assay to assess Dectin-2 in cancer tissues. ...
Development of a Novel Immunohistochemistry Assay to Characterize EDB+FN Protein Expression in Solid Tumors [0.03%]
一种新型免疫组化检测方法的开发用于鉴定实体瘤中EDB+FN蛋白的表达
Sara L Lewandowski,Chuan Shen,Liyang Diao et al.
Sara L Lewandowski et al.
Purpose: Tumor stroma, the cellular and non-cellular support system surrounding cancer cells, is a promising source of novel therapeutic targets. Extradomain-B of fibronectin (EDB+FN), a tumor-specific antigen expressed i...
Comprehensive Spatial Transcriptomic Profiling of Cribriform, Intraductal, Atypical Intraductal Proliferation, and Ductal Adenocarcinoma of the Prostate [0.03%]
前列腺筛状、导管内、非典型导管增生和导管腺癌的全面空间转录组谱分析
Ting Zhao,Cole Nawrocki,Linjie Xiong et al.
Ting Zhao et al.
Purpose: Cribriform (Crib) acinar adenocarcinoma (AAC), intraductal carcinoma of the prostate (IDC-P), atypical intraductal proliferation (AIP) and ductal adenocarcinoma (DAC) are linked to poor outcomes in prostate cance...
Tumor Immune Microenvironment and Clinicopathological Characteristics of Thoracic NUT Carcinoma [0.03%]
胸部NUT癌的肿瘤免疫微环境及临床病理特征分析
Keke Wang,Xu Cai,Chunyan Wu et al.
Keke Wang et al.
Purpose: This study aimed to provide a detailed clinicopathological, molecular genetics, and immune landscape analysis of a large cohort of primary thoracic NUT carcinomas to identify diagnostic challenges, uncover potent...
Tumor-infiltrating Basophils Are Associated With Improved Prognosis in Colorectal Cancer [0.03%]
肿瘤浸润性 basophil 与结直肠癌预后良好相关
Oskari Rahkola,Henna Karjalainen,Ville K Äijälä et al.
Oskari Rahkola et al.
Purpose: Basophils are rare granulocytic cells known for their role in allergic reactions, but they may also be involved in other diseases such as cancer. However, the role of tumor-infiltrating basophils in colorectal ca...
Changes in Three-Dimensional Intrahepatic Biliary Structures in Patients With Hepatobiliary Diseases Visualized Using Tissue-Clearing Methods [0.03%]
透明化技术可视化肝胆疾病患者的三维肝内胆道结构变化
Motoko Sasaki,Yasunori Sato,Yasuni Nakanuma
Motoko Sasaki
Purpose: Biliary lesions, including ductular reactions and biliary obstruction, are involved in the pathophysiology of human hepatobiliary diseases. However, little is known about the three-dimensional (3D) biliary struct...
Genome-wide SNP-based Profiling of Loss of Heterozygosity Reveals Distinct Molecular Subgroup-specific Patterns in Gastrointestinal Stromal Tumors (GIST) [0.03%]
基于全基因组SNP的杂合性丢失分析揭示了胃肠道间质瘤中不同分子亚型特有的杂合性丢失模式
Thais Maloberti,Margherita Nannini,Annalisa Astolfi et al.
Thais Maloberti et al.
Purpose: Gastrointestinal stromal tumors (GIST) are molecularly heterogeneous neoplasms defined by mutually exclusive driver alterations (KIT, PDGFRA, SDH, BRAF, RAS and NF1). However, driver mutations alone do not fully ...
AI-Assisted HER2 Scoring in Breast Cancer: Diagnostic Agreement and Understanding Discordance [0.03%]
人工智能辅助乳腺癌HER2评分：诊断一致性与理解分歧点
Frederik Deman,Dusan Rasic,Glenn Broeckx et al.
Frederik Deman et al.
Purpose: With trastuzumab deruxtecan demonstrating clinical benefit in HER2-low and ultralow breast cancer, precise discrimination at the lowest end of the HER2 immunohistochemistry (IHC) spectrum has become essential. In...
Corrigendum to "POU2F3 in Small Cell Lung Cancer (SCLC): Diagnostic Utility in Neuroendocrine-Low/Negative SCLC and Discrimination From Other Thoracic Malignancies and Other Small Blue Round Cell Tumors" [Laboratory Investigation 2026;106(6):106124] [0.03%]
“POU2F3在小细胞肺癌（SCLC）中的诊断应用及与其他胸部恶性肿瘤和小型蓝圆形细胞瘤的鉴别”[实验室调查2026；106（6）：106124] 的勘误表
Xiaoyan Chen,Fangfang Zou,Haimin Xu et al.
Xiaoyan Chen et al.