Deep Learning-Based Positive Region Segmentation and Spatial Registration of Virtual Multiplex Immunohistochemical Whole-Slide Images [0.03%]
基于深度学习的虚拟多重免疫组化全切片图像正区域分割与配准
Xiafei Shi,Liuna Wang,Dian Hu et al.
Xiafei Shi et al.
Purpose: This study aims to facilitate virtual multiplexing by establishing a deep learning-based analytical framework for precise identification and spatial reconstruction of positive regions in multiple immunohistochemi...
Pre-analytical Determinants of Patient Eligibility for Immune Checkpoint Inhibitors Revealed by Quantitative PD-L1 Analysis [0.03%]
定量PD-L1分析揭示影响免疫检查点抑制剂患者入组的前检验因素
Alessandro Gambella,Luca Mastracci,Chiara Trambaiolo et al.
Alessandro Gambella et al.
Purpose: The assessment of PD-L1 protein expression is a predictive biomarker for subsequent immune checkpoint inhibitor (ICI)-based therapies. The purpose of this study was to granularly and quantitatively define the imp...
The SMYD3-MEK/ERK Axis Contributes to Intestinal Metaplasia and H. pylori-associated Gastric Carcinogenesis [0.03%]
SMYD3-MEK/ERK信号轴促进肠上皮化生及幽门螺旋杆菌相关胃癌发生
Yuka Hirashita,Yoshiyuki Tsukamoto,Masaaki Kodama et al.
Yuka Hirashita et al.
Purpose: Chronic Helicobacter pylori (H. pylori) infection induces gastric atrophy and intestinal metaplasia (IM), which are key precancerous lesions for gastric cancer (GC). The purpose of this study was to determine the...
Paired Tissue and ctDNA Profiling Reveals Novel ESR1 Amplifications CDK4/6 Resistance Mechanisms in HR+/HER2- Metastatic Breast Cancers [0.03%]
配对组织和ctDNA检测发现HR+/HER2-转移性乳腺癌中的新型ESR1扩增和CDK4 / 6耐药机制
Liu Liu,Stephanie L Graff,Liang Cheng et al.
Liu Liu et al.
Purpose: With the availability of new treatment options such as selective estrogen receptor degraders (SERDs), CDK4/6 inhibitors (CDK4/6i), and PIK3CA inhibitors for hormone receptor-positive (HR+)/HER2- advanced and meta...
Immunohistochemical Assay Variability and HER2-low Breast Cancer Detection: A Laboratory Comparison in the Netherlands [0.03%]
免疫组化检测的变异性和HER2低表达乳腺癌的诊断：荷兰实验室对比研究
Zeynep E Kain,Emma Schuurman,Ximena Baez-Navarro et al.
Zeynep E Kain et al.
Purpose: HER2-low breast cancer (BC) has gained clinical relevance due to the efficacy of trastuzumab deruxtecan (T-DXd). However, variability in detecting low HER2 expression may affect patient eligibility. This nationwi...
Cross-Platform Comparative Spatial Transcriptomics in High-Grade Serous Carcinoma [0.03%]
高分级浆液性癌的跨平台比较空间转录组学
Omar Youssef,Lars Selander,Shuyu Zheng et al.
Omar Youssef et al.
Purpose: High-grade serous carcinoma (HGSC) is a remarkably heterogeneous tumor. The purpose of this study was to directly compare the reproducibility of transcriptomic profiles and biologically relevant molecular feature...
Detection and recurrence risk stratification of gastric cancer through DNA methylation profiling of blood [0.03%]
基于血液DNA甲基化谱的胃癌检测及复发风险分层研究
Jing Guo,Shun Zhang,Shuang Zhou et al.
Jing Guo et al.
Purpose: To develop a blood-based DNA methylation assay for noninvasive detection of gastric cancer (GC) across all stages, including early and premalignant lesions, and to evaluate whether preoperative GasAiQ positivity ...
"1 + 1 = 3": The Added Value of Combining Immunohistochemistry and Dual-Probe Chromogen In Situ Hybridization to Improve HER2 Status Evaluation [0.03%]
“1+1=3”——免疫组化与双探针染色原位杂交技术联合应用提高HER2状态评估的附加价值
Valentina Angerilli,Alessandro Gambella,Simona Pigozzi et al.
Valentina Angerilli et al.
Recommendations for Pathologist-led Deployment of Artificial Intelligence Tools as Lab-developed Tests [0.03%]
病理学家主导的人工智能工具作为实验室开发检验部署推荐意见
Allen W Zhang,Matthew J Cecchini,Ali Bashashati et al.
Allen W Zhang et al.
Upping the 'plex': Whole-slide, automated fourteen-color multiplex immunofluorescence staining of the tumor microenvironment in paraffin embedded tissue [0.03%]
“plex”升级版：全自动十四色多重免疫荧光染色技术对石蜡包埋组织切片中肿瘤微环境的整张全切片分析技术（WSI）
Jonathan Lai,Kyle S Cavagnini,Marcus Smith et al.
Jonathan Lai et al.
Purpose: Multiplex immunofluorescence (mIF) enables simultaneous visualization of multiple markers on a single slide. High-plex assays (>30 markers) typically rely on oligonucleotide (oligo)-tagged antibodies. Throughput ...