Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma [0.03%]
头颈部神经内分泌癌的临床病理和基因组特征
Akihiro Ohmoto,Yukiko Sato,Reimi Asaka et al.
Akihiro Ohmoto et al.
Neuroendocrine carcinoma (NEC) of the head and neck is a rare type of malignancy, accounting for only 0.3% of all head and neck cancers, and its clinicopathological and genomic features have not been fully characterized. We conducted a retr...
Histological regression in melanoma: impact on sentinel lymph node status and survival [0.03%]
黑色素瘤的组织学退行对其哨点淋巴结状态和生存期的影响
Karina Aivazian,Tasnia Ahmed,Mary-Ann El Sharouni et al.
Karina Aivazian et al.
Regression in melanoma is an immunological phenomenon that results in partial or complete replacement of the tumor with variably vascular fibrous tissue, often accompanied by pigment-laden macrophages and chronic inflammation. In some cases...
Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship [0.03%]
与乳腺植入物相关的阳性埃伯斯坦-巴病毒的大B细胞淋巴瘤：八例患者分析，提示可能存在病因关系
L Jeffrey Medeiros,Mario L Marques-Piubelli,Valentina F I Sangiorgio et al.
L Jeffrey Medeiros et al.
Breast implant anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm arising around textured breast implants that was recognized recently as a distinct entity by the World Health Organization. Rarely, other types of lymphoma have been ...
Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study [0.03%]
观察者之间的差异影响三阴性侵袭性乳腺癌间质肿瘤浸润淋巴细胞(sTILs)与病理完全缓解的关系：IVITA研究
Mieke R Van Bockstal,Aline François,Serdar Altinay et al.
Mieke R Van Bockstal et al.
High stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC) are associated with pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). Histopathological assessment of sTILs in TNBC biopsie...
PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma [0.03%]
鼻咽鳞状细胞癌中PD-L1表达、肿瘤浸润淋巴细胞、错配修复缺陷、EGFR突变和HPV感染的情况研究
Takahiro Hongo,Hidetaka Yamamoto,Rina Jiromaru et al.
Takahiro Hongo et al.
The antitumor efficacies of immune checkpoint inhibitors (ICIs) and the usefulness of potential predictive markers such as programmed death-ligand 1 (PD-L1) expression, density of tumor-infiltrating lymphocytes (TILs) and microsatellite ins...
Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients [0.03%]
肾细胞癌患者肿瘤内和肿瘤周组织的空间免疫图谱分析
Oscar Brück,Moon Hee Lee,Riku Turkki et al.
Oscar Brück et al.
While the abundance and phenotype of tumor-infiltrating lymphocytes are linked with clinical survival, their spatial coordination and its clinical significance remain unclear. Here, we investigated the immune profile of intratumoral and per...
Comparative molecular subtypes of index and metachronous gastric adenocarcinomas: a study of 42 Korean patients [0.03%]
基于42例韩国患者的胃腺癌分子亚型的对比分析研究
Baek-Hui Kim,Bence Kővári,Hayeon Kim et al.
Baek-Hui Kim et al.
To date, there have been no studies comparing the molecular subtypes of Index gastric cancers (IGCs) and metachronous gastric cancers (MGCs). We evaluated a cohort of 42 patients with 43 IGCs and 45 MGCs. Molecular subtyping was performed b...
Comedonecrosis Gleason pattern 5 is associated with worse clinical outcome in operated prostate cancer patients [0.03%]
comedonecrosis Gleason模式5与手术治疗后的前列腺癌患者更差的临床结果相关
Tim Hansum,Eva Hollemans,Esther I Verhoef et al.
Tim Hansum et al.
Individual growth patterns and cribriform architecture are increasingly considered in risk stratification and clinical decision-making in men with prostate cancer. Our objective was to establish the prognostic value of individual Gleason 5 ...
Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma [0.03%]
卵巢透明细胞癌患者正常宫腔内膜中频繁出现PIK3CA基因突变
Kosuke Murakami,Akiko Kanto,Kazuko Sakai et al.
Kosuke Murakami et al.
Recent studies have reported cancer-associated mutations in normal endometrium. Mutations in eutopic endometrium may lead to endometriosis and endometriosis-associated ovarian cancer. We investigated PIK3CA mutations (PIK3CAm) for three hot...
Quality control stress test for deep learning-based diagnostic model in digital pathology [0.03%]
基于深度学习的数字病理诊断模型的质量控制压力测试
Birgid Schömig-Markiefka,Alexey Pryalukhin,Wolfgang Hulla et al.
Birgid Schömig-Markiefka et al.
Digital pathology provides a possibility for computational analysis of histological slides and automatization of routine pathological tasks. Histological slides are very heterogeneous concerning staining, sections' thickness, and artifacts ...