Histologic Categorization of Desmoplastic Reaction in Triple-Negative Breast Cancer: Its Relevance to Neoadjuvant Chemoimmunotherapy Response and Tumor Biology [0.03%]
三阴性乳腺癌间质反应的组织学分类及其在新辅助化疗疗效和肿瘤生物学中的意义
Xunxi Lu,Bin Luo,Yani Wei et al.
Xunxi Lu et al.
Neoadjuvant chemoimmunotherapy (NACi) is a new standard treatment for early-stage high-risk triple-negative breast cancer (TNBC). Desmoplastic reaction (DR) is an important characteristic in the tumor-associated stroma of TNBC. Based on the...
CD38 Expression and 6q/9q Codeletion: Diagnostic Markers for Primary Cutaneous Cribriform Tumor [0.03%]
CD38表达和6q/9q复合缺失：原发性皮肤筛孔状肿瘤的诊断标记物
Paul W Harms
Paul W Harms
Diagnostic Discordance and Error in Breast Pathology: Causes, Classifications, and Medicolegal Implications [0.03%]
乳腺病理诊断分歧及错误的原因、分类及其医疗法律含义
Emad A Rakha,Cecily M Quinn,Elena Provenzano et al.
Emad A Rakha et al.
Diagnostic pathology is inherently interpretative and subject to interobserver variability. Whilst diagnostic concordance is a critical quality metric, distinguishing between acceptable variation, diagnostic error, and professional negligen...
DNA Methylation Profiling Classifies and Reveals Origin of Gynecologic Central Nervous System-like Tumors [0.03%]
基于DNA甲基化的谱系追踪和分类妇科中枢神经系统样肿瘤起源
Lucy Wang,Varshini Vasudevaraja,Jonathan Serrano et al.
Lucy Wang et al.
Gynecologic neuroectodermal tumors either exhibit central nervous system (CNS) differentiation (CNS-like) or represent Ewing sarcoma (EWS) which lacks CNS features and harbors FET-ETS gene fusions. DNA methylation profiling reclassified CNS...
Large Language Models Can Generate High-Quality Pathology Multiple-Choice Questions Comparable to Questions Written by a Human Expert [0.03%]
大型语言模型可以生成高质量的病理学多项选择题，与人类专家编写的问题相当
Michael J Borowitz,Amanda L Blackford,Suman Nagelia et al.
Michael J Borowitz et al.
Multiple-choice test questions (MCQs) can be effective tools to assess student and trainee performance, but the creation of these questions can be time consuming and requires expertise. To test the quality of pathology test questions create...
ZFTA::NCOA1/2-rearranged Epithelioid Mesenchymal Tumor-A Phenotypically Distinct Myoepithelial-like Neoplasm Epigenetically Overlapping with Chondroid Lipoma [0.03%]
ZFTA::NCOA1/2重排的上皮样间叶肿瘤-一种表型独特的肌上皮样新生物，其表观遗传学与软骨样脂肪瘤重叠
Raheel Rizwan,Vivek Venkataramani,Lukas Haug et al.
Raheel Rizwan et al.
ZFTA (formerly C11orf95) gene rearrangements are recurrent in rare tumors of the central nervous system, such as ependymomas (mostly ZFTA::RELA), and soft tissue tumors such as chondroid lipomas (ZFTA::MRTFB). To date, among mesenchymal tum...
A Comprehensive Mutational and Histopathological Analysis of STK11-Mutant Non-Small Cell Lung Carcinomas [0.03%]
STK11突变非小细胞肺癌的全面突变和组织病理学分析
Cristiana M Pineda,Zoe Guan,Hyunwoo Kwon et al.
Cristiana M Pineda et al.
Despite recent advances in the understanding of genomic and immunopathologic mechanisms of lung cancer, this disease remains the leading cause of cancer-related deaths in the United States. STK11 (LKB1) mutations are present in approximatel...
Optical Genome Mapping in Pediatric Hematologic Malignancies: High Diagnostic Yield and Unique Insights Across Leukemia Subtypes [0.03%]
儿科血液系统恶性肿瘤的光学基因组测绘：高诊断成功率和不同白血病亚型的独特见解
Travis H Smith,Jeffrey Jean,Stephen Phan et al.
Travis H Smith et al.
Hematologic neoplasms in pediatric patients have different genomic profiles compared to the same malignancies in adults, with copy number abnormalities (CNAs) and balanced structural variants (SVs) being the most prevalent types of oncogeni...
Retinoblastoma Protein Loss in p53 Abnormal Endometrial Carcinoma Is Associated With Poor Clinical Outcomes in a Canadian Cohort [0.03%]
加拿大一队列中p53异常的子宫内膜癌中视网膜母细胞瘤蛋白丢失与较差的临床结局相关
Allen W Zhang,C Blake Gilks,Lien Hoang et al.
Allen W Zhang et al.
Lung Carcinoma Metastatic to Breast: A Comprehensive Analysis of Clinical Presentation, Morphologic and Molecular Features, with Emphasis on Diagnostic Pitfalls [0.03%]
肺癌转移至乳腺的综合分析：临床表现、形态学和分子特征及其诊断陷阱的强调
Atif Ali Hashmi,Theodore Vougiouklakis,Andrea Gazzo et al.
Atif Ali Hashmi et al.
Lung carcinoma metastatic to the breast (bLM) or axillary lymph nodes (LnLM) may closely mimic primary triple-negative breast carcinoma (BC), leading to possible misdiagnosis. We characterized the clinical, morphologic, and molecular featur...