Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging [0.03%]
年龄相关性黄斑变性患者眼部基底膜骨桥蛋白沉积并可能作为衰老的生物标志物
Michael Lekwuwa,Mayur Choudhary,Eleonora M Lad et al.
Michael Lekwuwa et al.
A common clinical phenotype of several neurodegenerative and systemic disorders including Alzheimer's disease and atherosclerosis is the abnormal accumulation of extracellular material, which interferes with routine cellular functions. Simi...
Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934 [0.03%]
PD-L1免疫组化检测试剂盒与NIST标准参考物质1934的定量比较分析
Seshi R Sompuram,Emina E Torlakovic,Nils A &#x;t Hart et al.
Seshi R Sompuram et al.
Companion diagnostic immunohistochemistry (IHC) tests are developed and performed without incorporating the tools and principles of laboratory metrology. Basic analytic assay parameters such as lower limit of detection (LOD) and dynamic ran...
Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion [0.03%]
基于新型MTG1-CYP2E1融合基因的女性下生殖道血管肌纤维母细胞瘤与浅表性肌纤维母细胞瘤潜在的发病机制联系
Ryosuke Tajiri,Eisuke Shiba,Ryuji Iwamura et al.
Ryosuke Tajiri et al.
Angiomyofibroblastoma and superficial myofibroblastoma are distinctive benign mesenchymal tumors occurring in the female lower genital tract. Despite their significant overlapping clinicopathologic features, including the presence of bland-...
A comparative study of cirrhosis sub-staging using the Laennec system, Beijing classification, and morphometry [0.03%]
Laennec系统、北京分期与形态计量学评估肝硬化失代偿期患者肝纤维化比较研究
Xiaofei Zhang,Thomas D Schiano,Erin Doyle et al.
Xiaofei Zhang et al.
There is constant remodeling in a cirrhotic liver resulting in cirrhosis being spatially heterogeneous. The Laennec system, and, more recently the Beijing classification, have been used to sub-classify various degrees of cirrhosis. It is un...
Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases [0.03%]
结节性筋膜炎：17例报告及文献回顾
Zoltán Sápi,Zoltán Lippai,Gergő Papp et al.
Zoltán Sápi et al.
The self-limited nature of nodular fasciitis (NF) is well-known but its precise mechanism has not yet been clarified. We observed that "young" NF (preoperative duration 3 months) (~20%). Thus, we hypothesized that our original observation m...
YAP1-TFE3-fused hemangioendothelioma: a multi-institutional clinicopathologic study of 24 genetically-confirmed cases [0.03%]
YAP1-TFE3融合的血管内皮细胞瘤：24例基因确诊患者的临床病理多中心研究
Josephine K Dermawan,Elizabeth M Azzato,Steven D Billings et al.
Josephine K Dermawan et al.
YAP1-TFE3-fused hemangioendothelioma is an extremely rare malignant vascular tumor. We present the largest multi-institutional clinicopathologic study of YAP1-TFE3-fused hemangioendothelioma to date. The 24 cases of YAP1-TFE3-fused hemangio...
EZH2 expression is associated with inferior overall survival in mantle cell lymphoma [0.03%]
EZH2表达与套细胞淋巴瘤总生存率降低有关
Diana Martinez-Baquero,Ali Sakhdari,Huan Mo et al.
Diana Martinez-Baquero et al.
Enhancer of zeste homolog 2 (EZH2) is a catalytic component of the polycomb repressive complex 2 (PRC2) which reduces gene expression via trimethylation of a lysine residue of histone 3 (H3K27me3). Expression of EZH2 has not been assessed s...
A simplified breast cancer prognostic score: comparison with the AJCC clinical prognostic staging system [0.03%]
一种简化的乳腺癌预后评分系统：与美国癌症联合委员会临床预后分期系统的比较
Fei Fei,Kui Zhang,Gene P Siegal et al.
Fei Fei et al.
There have been many breast cancer prognostic models proposed in the last few decades, varying in their methods of development and validation, predictors, outcomes, and patients included. Most models were developed to assess prognostic outc...
Maximiliano Ramia de Cap,Sumedh Kaul
Maximiliano Ramia de Cap
Reexamining the molecular findings in specialized stromal tumors of the prostate [0.03%]
重新审视前列腺特化间质肿瘤的分子特征
Chin-Chen Pan,Jonathan I Epstein
Chin-Chen Pan