Deep learning trained on hematoxylin and eosin tumor region of Interest predicts HER2 status and trastuzumab treatment response in HER2+ breast cancer [0.03%]
基于苏木精和伊红肿瘤感兴趣区域训练的深度学习预测HER2状态及曲妥珠单抗治疗HER2阳性乳腺癌的疗效
Saman Farahmand,Aileen I Fernandez,Fahad Shabbir Ahmed et al.
Saman Farahmand et al.
The current standard of care for many patients with HER2-positive breast cancer is neoadjuvant chemotherapy in combination with anti-HER2 agents, based on HER2 amplification as detected by in situ hybridization (ISH) or protein immunohistoc...
Heterogeneity of programmed death-ligand 1 expression and infiltrating lymphocytes in paired resected primary and metastatic non-small cell lung cancer [0.03%]
配对可切除的原发和转移性非小细胞肺癌中的程序性死亡配体-1异质性和浸润淋巴细胞
Jianghua Wu,Wei Sun,Xin Yang et al.
Jianghua Wu et al.
Metastatic tumors (MTs) may show different characteristics of the immune microenvironment from primary tumors (PTs) in non-small cell lung cancer (NSCLC). The heterogeneity of immune markers in metastatic NSCLC and its associated factors ha...
Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer [0.03%]
子宫内膜癌中免疫检查点V域Ig含抑制T细胞活化分子(VISTA)的分析研究
Liju Zong,Shengwei Mo,Zezheng Sun et al.
Liju Zong et al.
V-domain Ig-containing suppressor of T-cell activation (VISTA) is a novel immune checkpoint protein and a potential immunotherapeutic target. However, its expression in endometrial cancer has not been clearly defined. This study aimed to in...
Targeting immune checkpoints in gynecologic cancer: updates & perspectives for pathologists [0.03%]
妇科肿瘤免疫检查点相关研究进展及病理学展望
Anne M Mills,Tim N Bullock,Kari L Ring
Anne M Mills
Checkpoint inhibitor-based immunotherapy is increasingly used in the treatment of gynecologic cancers, and most often targets the PD-1/PD-L1 axis. Pathologists should be familiar with the biomarkers required to determine candidacy for these...
Andrew Churg,Nolwenn Le Stang,Sanja Dacic et al.
Andrew Churg et al.
We report nine examples of a previously undescribed type of peritoneal circumscribed nodular mesothelial tumor characterized by nests or sheets of mesothelial cells with sharp cell borders and extremely bland, sometimes grooved, nuclei. In ...
Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer [0.03%]
基于图像的细胞外粘蛋白-肿瘤面积评估预测结直肠癌共识分子亚型(CMS)
Huu-Giao Nguyen,Oxana Lundström,Annika Blank et al.
Huu-Giao Nguyen et al.
The backbone of all colorectal cancer classifications including the consensus molecular subtypes (CMS) highlights microsatellite instability (MSI) as a key molecular pathway. Although mucinous histology (generally defined as >50% extracellu...
Sanja Dacic
Sanja Dacic
Mesothelial tumors are classified into benign or preinvasive tumors, and mesotheliomas. The benign or preinvasive group includes adenomatoid tumors, well-differentiated papillary mesothelial tumors, and mesothelioma in situ. Malignant tumor...
The histologic diagnosis of usual interstitial pneumonia of idiopathic pulmonary fibrosis. Where we are and where we need to go [0.03%]
寻常间质性肺炎的病理诊断。我们已到达何处和需去往何方
Maxwell L Smith
Maxwell L Smith
In the 50 years since its inception by Dr. Liebow, the diagnosis of usual interstitial pneumonia (UIP) by pathologists has changed significantly. This manuscript reviews the progressive history of the histologic diagnosis of UIP and summari...
Immunohistochemical staining patterns of p53 predict the mutational status of TP53 in oral epithelial dysplasia [0.03%]
口腔上皮异常增生中p53免疫组化染色特征可预测TP53基因突变状态
Keisuke Sawada,Shuji Momose,Ryutaro Kawano et al.
Keisuke Sawada et al.
Next-generation sequencing of oral squamous cell carcinoma (OSCC) has revealed TP53 as the most frequently mutated gene in OSCC mutually exclusive with human papillomavirus infection. Oral epithelial dysplasia (OED) is defined as a precance...
Expanding the spectrum of PLAG1-rearranged lipoblastomas arising in patients over 45, with identification of novel fusion partners [0.03%]
PLAG1重排的脂母细胞瘤患者的谱系扩展，鉴定新的融合伴侣
Iva Brčić,Jasminka Igrec,Iris Halbwedl et al.
Iva Brčić et al.