Epstein-Barr Virus-associated gastric cancer: a histopathologic study with comprehensive molecular profiling [0.03%]
与EB病毒相关的胃癌：系统分子病理特征研究
Valentina Angerilli,Jessica Gasparello,Antonio Collesei et al.
Valentina Angerilli et al.
A subset of gastric cancers (GCs) is linked to Epstein-Barr virus (EBV) infection. This study aims to characterize the histopathological and molecular features of EBV-associated GCs (EBVaGCs), focusing on predictive biomarkers and genomic a...
HNF1A-inactived Hepatocellular Adenomas in Fibropolycystic Kidney and Liver Disease Are Associated with Germline HNF1B Variant [0.03%]
与遗传性HNF1B变异相关的纤维多囊型肾肝病的HNF1A失活肝细胞腺瘤
Catherine E Hagen,Dipti M Karamchandani,Luisa Ricaurte et al.
Catherine E Hagen et al.
HNF1A-inactivated hepatocellular adenomas are rarely described in patients with hepatorenal fibrocystic disease, and their genetic relationship remains unexplored. This study reports a series of HNF1A-inactivated hepatocellular adenomas wit...
Cross-platform methylation-based site of origin classification for squamous cell carcinomas [0.03%]
跨平台的鳞状细胞癌甲基化位点起源分类方法
Allen W Zhang,Vahid Akbari,Andrew Galbraith et al.
Allen W Zhang et al.
Squamous cell carcinomas (SCCs) are one of the most common cancer types and can arise at nearly any anatomic site. As SCCs are one of the most common metastases, do not have reliable site-specific morphologic or genomic features and have co...
Digital Spatial Profiling Demonstrates Differences Between Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans and its Conventional Counterparts [0.03%]
数字空间分析揭示了皮下肉瘤样肿瘤的纤维肉瘤转化与其常规形态之间的差异
Nicholas Frazzette,Suvrajit Maji,Nada Mohamed et al.
Nicholas Frazzette et al.
Dermatofibrosarcoma protuberans (DFSP) is a neoplasm of the dermis with a tendency for aggressive local growth and recurrence. A minority of DFSP cases may transform into higher-grade sarcoma (fibrosarcomatous transformation, FST-DFSP) whic...
Follicular helper T-cell lymphomas with EBV-positive neoplastic cells: a rare scenario with diagnostic implications [0.03%]
携带EB病毒的新生物细胞的滤泡性辅助T细胞淋巴瘤：一种罕见的情况及诊断意义
Barbara Burroni,Claire Lamaison,Elsa Poullot et al.
Barbara Burroni et al.
Follicular helper T-cell lymphomas (TFHL) of the angioimmunoblastic type (AITL) and other TFHL variants often contain EBV-positive B-blasts, but EBV infection of the neoplastic T-cells has rarely been documented. Here, we report 10 cases of...
TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC) [0.03%]
FISH阴性MITF家族改变的肾细胞癌中TRIM63过表达
Rahul Mannan,Ying-Bei Chen,Xiaoming Wang et al.
Rahul Mannan et al.
TFE3 and TFEB break-apart fluorescent in situ hybridization (FISH) assays are the gold standard for diagnostic confirmation of MiTF family altered renal cell carcinoma (MiTF RCC), which includes TFE3 rearranged RCC, and TFEB altered RCC. Ho...
ApoE immunostaining has diagnostic utility in differentiating dense deposit disease and C3 glomerulonephritis: Clone-based evaluation of D719N, EP1373Y and 1B2C9 [0.03%]
APOE免疫组化在鉴别致密物沉积病和C3肾小球病中的诊断价值：基于克隆的D719N、EP1373Y和1B2C9抗体评估
Ozge Hurdogan,Safak Mirioglu,Ahmet Burak Dirim et al.
Ozge Hurdogan et al.
Electron microscopy (EM) has been essential for the diagnosis of dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Recent research showed significantly higher accumulation of apolipoprotein E (ApoE) in DDD compared to C3GN and t...
Naoyuki Oka,Satsuki Kishikawa,Jumpei Kashima et al.
Naoyuki Oka et al.
Adenocarcinoma in situ (AIS) of the lungs has been increasingly diagnosed worldwide following the establishment of its diagnostic criteria along with advances in computed tomography (CT) imaging technology. We encountered a series of AIS wi...
Uterine Sarcomas with Recurrent KDM2B Gene Fusions: Three Cases of a Possible Novel Subtype of High-Grade Endometrial Stromal Sarcoma [0.03%]
KDM2B基因重排的子宫肉瘤：可能的新型高级别子宫内膜间质肉瘤亚型三例报告
Kyle M Devins,Nathalène Truffaux,Rihab Azmani et al.
Kyle M Devins et al.
The advent of widespread genomic testing of uterine mesenchymal tumors has led to novel insights into the biology of these diverse tumors, and many genomically-defined entities have been described in recent years. During a larger study of e...
Deep learning on histological slides accurately predicts Consensus Molecular Subtypes and spatial heterogeneity in colon cancer [0.03%]
基于组织切片的深度学习精确预测结直肠癌的共识分子亚型和空间异质性
Jean-Eudes LE Douget,Paul Jacob,Côme Lepage et al.
Jean-Eudes LE Douget et al.
Colon cancer (CC) is the third most prevalent cancer type. It is highly heterogeneous, particularly in terms of molecular profiles, which have both prognostic and predictive impacts on the treatment efficacy. However, CC treatment in adjuva...