AI-driven screening of equivocal prostate IHC cases: development and validation of a screening and cancer detection framework [0.03%]
基于人工智能的前列腺IHC可疑病例筛查：筛查和检测框架的建立与验证
Ramin Nateghi,Ruoji Zhou,Madeline Saft et al.
Ramin Nateghi et al.
Artificial intelligence has been proposed as a solution to meet increasing demand for the diagnostic services of pathologists. Prostate biopsies are a significant source of this demand, and substantial fraction of these biopsies require imm...
GLUT1 Expression Patterns in Verruciform Acanthotic Vulvar Squamous Intraepithelial Neoplasia, HPV-independent p53 Wild-Type Squamous Cell Carcinoma and Benign Vulvar Lesions [0.03%]
GLUT1在 verruciform 鳞状上皮内瘤变、HPV阴性的野生型p53鳞癌和良性病变中的表达模式
Gloria Zhang,Robert A Soslow,Bin Yang
Gloria Zhang
Verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN) is a rare type of HPV-independent vulvar squamous cell carcinoma (SCC) precursor lacking aberrant p53 expression. Our recent study demonstrated GLUT1 overexpression in vulvar S...
HER2-ultralow Breast Cancer: Incidence, Clinicopathologic Features and Need for Refined Scoring System [0.03%]
HER2 超低表达乳腺癌：发生率、临床病理特征及细化评分系统的必要性
Doaa Morrar,Edi Brogi,Christopher J Schwartz et al.
Doaa Morrar et al.
Patients with metastatic HER2-low breast cancer (BC), defined as IHC 1+ or IHC 2+/ISH-negative, have demonstrated clinical benefit from antibody-drug conjugates (ADCs) such as trastuzumab deruxtecan. The DESTINY-Breast06 trial further demon...
Histopathologic Insights into Curvularia-Induced Chronic Granulomatous Fungal Sinusitis: A Guide for Surgical Pathologists [0.03%]
关于弯孢霉引起的慢性肉芽肿型真菌性鼻窦炎的组织病理学见解——外科病理学家参考指南
Ashleigh N Riegler,Jessica W Grayson,Jacob W Greenway et al.
Ashleigh N Riegler et al.
Chronic granulomatous fungal sinusitis (CGFS) is a rare, debilitating infection characterized by an enlarging mass affecting the orbit, nose, palate, and paranasal sinuses, with occasional intraorbital and intracranial extension. Most cases...
Loss of RPL22 Expression Identifies a Transcriptional Subset of MLH1 Deficient Endometrial Cancers with Lower Numbers of Tumor-Associated Lymphocytes [0.03%]
RPL22表达缺失鉴别出MLH1缺陷型子宫内膜癌的一个转录亚型，肿瘤浸润淋巴细胞数量较少
Macy L Osborne-Frazier,Savannah E LaBuda,Molly L Parrish et al.
Macy L Osborne-Frazier et al.
MSI-high defines one of the major subsets of endometrial cancer, characterized by defects in DNA mismatch repair, most often by loss of MLH1 protein expression, and sensitivity to immunotherapies. RPL22 is selectively mutated in MSI-high ca...
A Distinctive DICER1-related Wilms-like Uterine Tumor: A Report of 8 Cases [0.03%]
一种独特的DICER1相关的类似Wilms病的子宫肿瘤：8例报告
Gulisa Turashvili,Sabrina Croce,Ben Davidson et al.
Gulisa Turashvili et al.
The presence of DICER1 mutations associated with overlapping morphologic features in tumors arising at different sites has been suggested to define an emerging category of DICER1-related neoplasms. We undertook a clinicopathologic and molec...
Whole-Slide Imaging and Radiological Features Predict Clinical Outcomes in Patients with Neuroendocrine Tumors of the Lung [0.03%]
基于全景病理影像及放射组学特征的肺神经内分泌肿瘤预后模型研究
Sevinj Yolchuyeva,Leyla Ebrahimpour,Yannick Lemaréchal et al.
Sevinj Yolchuyeva et al.
Neuroendocrine tumors (NETs) are rare and heterogeneous cancers that vary in clinical presentation, biology, and treatment response. They exhibit slow growth with varying levels of aggressiveness, highlighting the need for reliable biomarke...
Integrated multiomics analysis of MSI-H colorectal cancer identifies a subtype with poor outcome [0.03%]
整合型多组学分析发现MSI-H型结直肠癌的一个不良预后亚型
Gangzhi Zhang,Biting Zhou,Xiaoxian Xu et al.
Gangzhi Zhang et al.
Up to 50% of patients with metastatic microsatellite instability-high (MSI-H) colorectal cancer (CRC) are resistant to immunotherapy and experience progression or recurrence after treatment. We integrated the genomic, epigenomic, transcript...
EWSR1::CREM Tumor of the Kidney With Florid Tubular Proliferation: Expanding the Spectrum of Biphasic Renal Tumors [0.03%]
具有明显管状增生的EWSR1::CREM肾肿瘤：双相性肾肿瘤谱系的扩展
Sean R Williamson,Reza Alaghehbandan,Jesse K McKenney et al.
Sean R Williamson et al.
An integrated clinical genomic and transcriptomic subgrouping of central chondrosarcoma [0.03%]
中央软骨肉瘤的临床基因组和转录组图谱集成分型研究
Debora M Meijer,Sanne Venneker,Baptiste Ameline et al.
Debora M Meijer et al.
Central conventional chondrosarcoma, a malignant cartilage-producing bone tumor, is the second most-common bone sarcoma. Chondrosarcomas are histologically graded, which is so far the best predictor of survival. Early mutations in isocitrat...