Clinical Grade Interpretable Artificial Intelligence Tool for Automated Detection of Lymph Node Metastasis in Prostate Cancer [0.03%]
临床适用且可解释的人工智能工具在前列腺癌淋巴结转移的自动化检测中的应用
Fatemeh Zabihollahy,Kangdi Shi,Collins Wangulu et al.
Fatemeh Zabihollahy et al.
Lymph node metastasis (LNM) is a critical prognostic factor for prostate cancer and is associated with increased mortality and poor clinical outcomes, necessitating modifications to therapeutic strategies. Manual histopathological evaluatio...
MSAI-Path: Predicting Microsatellite Instability from Routine Histology Slides Without Re-inventing the Wheel [0.03%]
基于常规组织切片预测微卫星不稳定性的方法（无需重新发明轮子）
Elias Baumann,Luca E M Schäfer,Frédérique Meeuwsen et al.
Elias Baumann et al.
Microsatellite instability (MSI) is an important biomarker in colorectal cancer, influencing both patient prognosis and treatment decisions. Current approaches for MSI prediction from hematoxylin and eosin-stained whole slide images (WSI) r...
BRAF p.Val600Glu mutations are not detected in adenomatoid odontogenic tumors [0.03%]
腺样牙源性肿瘤中未检出BRAF p.Val600Glu基因突变
Josiane Gonçalves,Bruna Pizziolo Coura,Vanessa Fátima Bernardes et al.
Josiane Gonçalves et al.
The adenomatoid odontogenic tumor (AOT) is a benign, encapsulated odontogenic tumor characterized by slow growth and indolent behavior. AOT shows MAPK/ERK pathway activation and KRAS p.Gly12Val or p.Gly12Arg mutations occur in 70% of cases....
Low Grade Fibro-Osseous Lesions with Isolated Chromosome 12 Chromothripsis: A Distinct Entity or a Low-Grade Central Osteosarcoma with a Novel Driver? [0.03%]
低级别成骨性纤维组织病伴有孤立的12号染色体碎裂重排：一种独立实体还是具有新驱动基因改变的低级别中心型骨肉瘤？
Carla Saoud,Yanming Zhang,Jamal Benhamida et al.
Carla Saoud et al.
Chromothripsis, a catastrophic genomic event causing extensive chromosomal fragmentation and rearrangement, has been identified in conventional osteosarcoma, contributing to karyotypic heterogeneity. Chromothripsis was also detected in a su...
An Exploratory Application of a CNS Tumor Methylation Classifier in Ovarian Neuroectodermal Tumors [0.03%]
CNS肿瘤甲基化分类器在卵巢神经上皮性肿瘤中的探索应用
Jie Yang,Tianyu Zhang,Ying Zhang et al.
Jie Yang et al.
Ovarian neuroectodermal tumors (NETs) are rare malignancies with unclear diagnostic criteria and challenging treatment. We aimed to assess the utility of DNA methylation in the diagnostic classification and prognostic stratification of ovar...
Defining NECTIN4 Amplification and Protein Expression in Urothelial Carcinoma and Histologic Subtypes [0.03%]
尿路上皮癌及组织学亚型中NECTIN4拷贝数扩增和蛋白表达的分布特点及其预后意义
John C Cheville,Jacob J Orme,Sounak Gupta et al.
John C Cheville et al.
Chromosome 1q23.3 is commonly amplified in metastatic urothelial carcinoma (UC). This region contains NECTIN4 that encodes for a membrane protein, and amplification may result in increased NECTIN4 expression. Enfortumab vedotin (EV), an ant...
International Expert Consensus Recommendations for HER2 Reporting in Breast Cancer: Focus on HER2-low and Ultralow Categories [0.03%]
国际乳腺癌HER2检测报告专家共识推荐：HER2低表达和超低表达亚组的聚焦与解读
Emad A Rakha,Puay Hoon Tan,Mieke R Van Bockstal et al.
Emad A Rakha et al.
The concept of "HER2-negative" breast cancer is evolving, with the recognition of HER2-low and HER2-ultralow subsets. These subsets are clinically relevant regarding treatment with the antibody-drug conjugate trastuzumab deruxtecan (T-DXd),...
Expanding the Clinicopathologic Spectrum of EWSR1::SSX-Rearranged Sarcomas: Series of 11 Cases Including Osteosarcomas and a Novel EWSR1::SSX4 Fusion [0.03%]
EWSR1::SSX重排肉瘤的临床病理谱系扩展：包括骨肉瘤和新型EWSR1::SSX4融合的11例病例系列分析
John M Gross,David I Suster,Ying Zou et al.
John M Gross et al.
Gene rearrangements involving EWSR1 or SSX genes are known to play a role in sarcomagenesis; however, sarcomas harboring EWSR1::SSX fusions are rare. To better understand tumors associated with this distinctive genetic event, we studied 11 ...
A Novel Mutational Signature in Cancers Following Solid Organ or Allogeneic Stem Cell Transplantation [0.03%]
实体器官或同种异基因造血干细胞移植后癌症中的新型突变特征
Igor Odintsov,Stephanie E Siegmund,Navin R Mahadevan et al.
Igor Odintsov et al.
Transplant recipients are at a heightened risk of cancer, yet the full spectrum of etiologic factors is poorly understood. Here, we analyze the mutational patterns in a clinically diverse cohort of 41,874 cancers and identify a novel mutati...