Identification of nodal micrometastasis in colorectal cancer using deep learning on annotation-free whole-slide images [0.03%]
基于无标注全切片图像的深度学习在结直肠癌淋巴结微转移检测中的应用研究
Wen-Yu Chuang,Chi-Chung Chen,Wei-Hsiang Yu et al.
Wen-Yu Chuang et al.
Detection of nodal micrometastasis (tumor size: 0.2-2.0 mm) is challenging for pathologists due to the small size of metastatic foci. Since lymph nodes with micrometastasis are counted as positive nodes, detecting micrometastasis is crucial...
Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners [0.03%]
乳腺结节性筋膜炎的临床病理和分子特征以及新型USP6融合伴侣的鉴定
Jeffrey M Cloutier,Christian A Kunder,Gregory W Charville et al.
Jeffrey M Cloutier et al.
Nodular fasciitis is a benign, self-limited, pseudosarcomatous neoplasm that can mimic malignancy due to its rapid growth, cellularity, and mitotic activity. Involvement of the breast is rare and diagnosis on biopsy can be challenging. In t...
EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma [0.03%]
EWSR1-PATZ1基因融合型肾细胞癌：甲状腺样滤泡性肾细胞癌的复发性基因重排标志物
Khaleel I Al-Obaidy,Julia A Bridge,Liang Cheng et al.
Khaleel I Al-Obaidy et al.
Thyroid-like follicular renal cell carcinoma is an uncommon kidney tumor with no distinct molecular alteration described to date. This cohort of eight women with mean and median ages of 45 and 46 years, respectively (range 19-65 years), had...
EWSR1-WT1 gene fusions in neoplasms other than desmoplastic small round cell tumor: a report of three unusual tumors involving the female genital tract and review of the literature [0.03%]
EWSR1-WT1基因融合在除小圆细胞肿瘤以外的肿瘤中的作用：3例累及女性生殖道罕见肿瘤的报告及文献复习
J Kenneth Schoolmeester,Andrew L Folpe,Asha A Nair et al.
J Kenneth Schoolmeester et al.
Desmoplastic small round cell tumor (DSRCT) is a high-grade round cell sarcoma that typically arises in the abdominopelvic cavity of young males, co-expresses keratins and desmin, and carries a pathognomonic EWSR1-WT1 gene fusion. The EWSR1...
Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine [0.03%]
妊娠滋养细胞疾病基因分型诊断：精准医学前沿进展
Natalia Buza,Pei Hui
Natalia Buza
Investigations in recent decades have exploited tissue DNA genotyping as a powerful ancillary tool for the precision diagnosis and subclassification of gestational trophoblastic disease. As lesions of gestational origin, the inherited pater...
Superficial ALK-rearranged myxoid spindle cell neoplasm: a cutaneous soft tissue tumor with distinctive morphology and immunophenotypic profile [0.03%]
表皮ALK重排的黏液样梭形细胞肿瘤：一种具有特征性形态和免疫表型的皮肤软组织肿瘤
Josephine K Dermawan,Elizabeth M Azzato,John R Goldblum et al.
Josephine K Dermawan et al.
Gene rearrangements involving the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase gene have been identified in various neoplasms, including inflammatory myofibroblastic tumor and epithelioid fibrous histiocytoma. We present an ALK...
Farhan Khan,John S A Chrisinger,Horacio M Maluf
Farhan Khan
Myofibroblastic stromal hyperplasia (MSH) is the proposed name for a benign spindle cell proliferation of the mammary stroma, which often raises clinical and radiographic concern for a mass or a malignant process. Ten cases were retrieved f...
Fibroma of tendon sheath is defined by a USP6 gene fusion-morphologic and molecular reappraisal of the entity [0.03%]
腱鞘纤维瘤的USP6基因融合及相关实体的形态和分子再评价
Jože Pižem,Alenka Matjašič,Andrej Zupan et al.
Jože Pižem et al.
Fibroma of tendon sheath (FTS) is an uncommon benign myofibroblastic neoplasm that arises in association with tenosynovial tissue. Fusions of the USP6 gene have been recently documented in a proportion of so-called "cellular FTS" but not in...
Histologic and genomic features of breast cancers with alterations affecting the SWI/SNF (SMARC) genes [0.03%]
与SWI/SNF（SMARC）基因改变的乳腺癌的组织病理学和基因组特征
Christopher J Schwartz,Fresia Pareja,Edaise M da Silva et al.
Christopher J Schwartz et al.
The SWI/SNF family of proteins is a multisubunit ATPase complex frequently altered in human cancer. Inactivating mutations in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (SMARCs) underpin a subset of tumors such...
Ian A Cree,Puay Hoon Tan,William D Travis et al.
Ian A Cree et al.
Mitoses are often assessed by pathologists to assist the diagnosis of cancer, and to grade malignancy, informing prognosis. Historically, this has been done by expressing the number of mitoses per n high power fields (HPFs), ignoring the fa...