Computational Pathology for Accurate Prediction of Breast Cancer Recurrence: Development and Validation of a Deep Learning-based Tool [0.03%]
基于深度学习的乳腺癌复发预测计算病理学工具的研发与验证
Ziyu Su,Yongxin Guo,Robert Wesolowski et al.
Ziyu Su et al.
Accurate recurrence risk stratification is crucial for optimizing treatment plans for breast cancer patients. Current prognostic tools like Oncotype DX (ODX) offer valuable genomic insights for HR+/HER2- patients but are limited by cost and...
Deep Learning Predicts Survival Across Squamous Tumor Entities From Routine Pathology: Insights from Head and Neck, Esophagus, Lung and Cervical Cancer [0.03%]
基于常规病理的深度学习预测头颈、食道、肺和宫颈鳞癌生存率的跨实体研究
Verena Bitto,Xiaofeng Jiang,Michael Baumann et al.
Verena Bitto et al.
Computational pathology-based models are becoming increasingly popular for extracting biomarkers from images of cancer tissue. However, their validity is often only demonstrated on a single unseen validation cohort, limiting insights into t...
GLI1-Altered Tumors of the Ovary A Report of Four Cases of an Underrecognized Neoplasm That May Mimic Sex Cord-Stromal Tumors [0.03%]
卵巢GLI1异常肿瘤四例报告一种易被误诊为性索间质肿瘤的少见肿瘤类型
Kyle M Devins,Adam S Fisch,Robert H Young et al.
Kyle M Devins et al.
GLI1-altered neoplasms are an emerging group of tumors of presumed mesenchymal derivation which occur mostly in the head and neck or soft tissues of the trunk and extremities. We have recently identified four ovarian neoplasms with GLI1 gen...
Comparative analysis of somatic and germline polymerase proofreading deficiencies in cancer: molecular and clinical implications [0.03%]
癌症中体细胞和生殖系聚合酶校正缺陷的比较分析：分子和临床意义
Julen Viana-Errasti,Raúl Marín,Sandra García-Mulero et al.
Julen Viana-Errasti et al.
Polymerases ε and δ maintain genome integrity through exonuclease proofreading. Germline and somatic pathogenic variants (PVs) in the exonuclease domain (ED) of POLE and POLD1 impair proofreading, causing hypermutated tumors. Despite shar...
John M Gross,Ying S Zou,Michael Michal et al.
John M Gross et al.
This investigation describes the clinicoradiologic, pathologic, and molecular features of a unique soft tissue tumor characterized by a peripheral shell of bone and composed of bland myoid spindle and epithelioid cells that are keratin-posi...
A Genomic Alteration in GATA3 Affects Treatment Responses with a CDK4/6 Inhibitor Collaborating with p18INK4C Expression in Advanced Breast Carcinoma [0.03%]
GATA3基因组的改变影响了晚期乳腺癌中CDK4/6抑制剂的治疗反应并与p18INK4C表达协同作用
Xiao Huang,Sooryanarayana Varambally,Sarah A Anderson et al.
Xiao Huang et al.
Cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) with endocrine therapy benefits patients with hormone receptor (HR)-positive, human epidermal growth receptor 2 (HER2)-negative breast carcinomas. However, most tumors develop resistance t...
Exploring the genetic landscape of primary marginal zone lymphoma of the urinary bladder [0.03%]
探究原发性尿膀胱边缘区淋巴瘤的遗传谱系
Ilaria Balestri,Vanesa-Sindi Ivanova,Gorana Gašljević et al.
Ilaria Balestri et al.
Extranodal marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue is the most frequent primary lymphoma of the urinary bladder. While MZLs from various anatomical sites are often associated with autoimmune disorders, infec...
Hyalinizing Clear Cell Carcinoma (HCCC) of the Head and Neck: A Multicenter Retrospective Study of 87 Cases Focusing on Prognostic Pathologic Features and Grading scheme [0.03%]
透明细胞玻璃样变性癌（HCCC）的头颈部肿瘤：一项针对87例患者的多中心回顾性研究，重点关注预后病理特征和分级方案
Bin Xu,Kartik Viswanathan,Marie Barbesier et al.
Bin Xu et al.
Hyalinizing clear cell carcinoma (HCCC) is a salivary gland carcinoma characterized by the presence of clear and eosinophilic cells within a hyalinized stroma and the EWSR1 rearrangement. Aiming to identify prognostic factors and establish ...
Pitfalls in the histological diagnosis of morphologic variants of invasive lobular carcinoma of the breast [0.03%]
乳腺浸润性小叶癌组织学亚型诊断陷阱分析
Giuseppe Floris,Lounes Djerroudi,Gitte Zels et al.
Giuseppe Floris et al.
Invasive lobular carcinoma (ILC) is the second most frequent histological type of breast cancer and the most frequent special type. Disruption of cell-to-cell adhesion, caused most often by E-cadherin loss of function, results in the distin...
Distinct Patterns of GLUT1 Expression in HPV-associated and HPV-independent Vulvar Intraepithelial Neoplasia and Squamous Cell Carcinoma [0.03%]
与HPV相关和无关的外阴鳞状细胞癌及上皮内瘤变中GLUT1表达的不同模式
Gloria Zhang,Bin Yang
Gloria Zhang
The expression of GLUT1 in vulvar squamous cell carcinoma and its precursors remains largely unknown. We systematically investigated GLUT1 expression in HPV-associated and HPV-independent vulvar intraepithelial neoplasia (VIN) and squamous ...