Marc Veldhoen
Marc Veldhoen
The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation [0.03%]
IL17REL基因编码了一个针对IL-17家族细胞因子的诱饵受体以控制肠道炎症
Qi Li,Xiaoyu Li,Yunwei Lou et al.
Qi Li et al.
The IL17REL gene locus has been associated with susceptibility to inflammatory bowel disease (IBD). However, whether it encodes a functional protein and whether its IBD risk variants causally contribute to disease pathogenesis remain unknow...
Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy [0.03%]
通过抑制ALDH1A2作用于自分泌维甲酸信号通路可增强抗肿瘤树突状细胞疫苗的疗效
Cao Fang,Mark Esposito,Ulrike Hars et al.
Cao Fang et al.
Strategies to stimulate dendritic cell (DC) activity, such as ex vivo generation and priming of DC vaccines, have been explored as cancer immunotherapies owing to their potential to elicit antitumor T cell responses. Despite decades of rese...
Eng Eong Ooi
Eng Eong Ooi
Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury [0.03%]
淋巴毒素依赖的脑膜CXCL13:BAFF比值升高导致灰质损伤
Ikbel Naouar,Andrei Pangan,Michelle Zuo et al.
Ikbel Naouar et al.
In multiple sclerosis (MS), B cell-rich tertiary lymphoid tissues (TLTs) in the brain leptomeninges associate with cortical gray matter injury. Using a model of Th17 cell-driven experimental autoimmune encephalomyelitis in mice, we found th...
IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans [0.03%]
人初次感染寨卡病毒后，IgA驱动的中性粒细胞活化是登革热重症化的幕后黑手
Jaime A Cardona-Ospina,Vicky Roy,Dorca E Marcano-Jiménez et al.
Jaime A Cardona-Ospina et al.
The four dengue virus serotypes (DENV1-4) and the related Zika flavivirus (ZIKV) are major public health concerns worldwide. Primary immunity against ZIKV increases the risk of a subsequent severe DENV2 infection, presenting a significant c...
Daichi Nonaka,Steffen Jung
Daichi Nonaka
Inflammatory stress-induced amino acid transformation generates diabetogenic T cells [0.03%]
炎症压力引起的氨基酸转化产生致糖尿病T细胞
Amir Ghorbani,Jonathan W Yewdell
Amir Ghorbani