DC subsets and states unraveled across human juxtatumoral and malignant tissues [0.03%]
人正常肿瘤浸润边缘和恶性组织中的DC表型及功能异质性研究进展
Kevin Mulder,Margaux Gardet,Wan Ting Kong et al.
Kevin Mulder et al.
Dendritic cells (DCs) are professional antigen-presenting cells. While plasmacytoid DCs (pDCs) are poor antigen-presenting cells at steady state, myeloid DCs (mDCs), which include DC1s, DC2s and DC3s, are specialized in T cell priming. To g...
Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis [0.03%]
单细胞多组学特征揭示成人及儿童脓毒症的解剖部位特异性免疫特征
Qian Ye,Xiaofei Lai,Yuliang Liu et al.
Qian Ye et al.
The anatomical source of infection is a major determinant of sepsis outcomes; however, how distinct sites shape immunity remains unclear. Here we applied multi-omic profiling, integrating single-cell transcriptomics, single-cell T cell rece...
Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity [0.03%]
作者更正：缺氧通过诱导早幼粒细胞组蛋白切割和H3K4me3丢失从而长期损害中性粒细胞免疫功能
Manuel A Sanchez-Garcia,Pranvera Sadiku,Brian M Ortmann et al.
Manuel A Sanchez-Garcia et al.
Published Erratum
Nature immunology. 2025 Dec 1. DOI:10.1038/s41590-025-02380-8 2025
Author Correction: Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia [0.03%]
作者更正：儿童急性淋巴细胞白血病克隆演进的机制
Srividya Swaminathan,Lars Klemm,Eugene Park et al.
Srividya Swaminathan et al.
Published Erratum
Nature immunology. 2025 Nov 28. DOI:10.1038/s41590-025-02375-5 2025
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes [0.03%]
微环境驱动的HLA-II相关胰岛素新生抗原可激活糖尿病持久记忆T细胞
Neetu Srivastava,Anthony N Vomund,Rongzhen Yu et al.
Neetu Srivastava et al.
The antigenic landscape of autoimmune diabetes reflects a failure to preserve self-tolerance, yet how novel neoantigens emerge in humans remains incompletely understood. Here we designed an immunopeptidomics-based approach to probe HLA-II-b...
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs [0.03%]
肠神经系统衍生的P物质通过限制LGR5+干细胞向分泌谱系分化来阻碍II型免疫程序
Manuel O Jakob,Nele Sterczyk,Sotiria Boulekou et al.
Manuel O Jakob et al.
Barrier homeostasis relies on a finely tuned interplay between the immune system, epithelial cells and commensal microbiota. Beyond these regulators, the enteric nervous system has recently emerged as a central hub coordinating intestinal i...
Neuroepithelial VIP-VIPR1 interactions differentially control enteric type 1 and type 2 immunity [0.03%]
神经上皮VIP-VIPR1相互作用分别调控肠驻留髓样细胞和T辅助细胞的分化
Roksana M Pirzgalska,Beatriz Henriques-Alves,Bruno Raposo et al.
Roksana M Pirzgalska et al.
The nervous and immune systems cooperate to regulate mucosal barrier integrity. Nevertheless, whether enteric neurons establish neuroepithelial interactions to coordinate immunity remains elusive. Here, we identified neuroepithelial interac...
Stabilizing iTreg cells [0.03%]
稳定iTreg细胞
Nicholas J Bernard
Nicholas J Bernard
Stephanie Houston
Stephanie Houston
Distal directives [0.03%]
远程指令的影响分析
Laurie A Dempsey
Laurie A Dempsey