BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells [0.03%]
BACH2剂量建立了CAR-T细胞干细胞等级和精调了抗肿瘤免疫反应
Taidou Hu,Ziang Zhu,Ying Luo et al.
Taidou Hu et al.
Stem-like T cells promote the efficacy of immunotherapy and are heterogeneous in stemness, with long-term (LT) stem-like T cells at the apex of this hierarchy. How the stemness hierarchy is regulated in chimeric antigen receptor (CAR) T cel...
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy [0.03%]
调节BACH2剂量平衡干细胞特性与效应细胞功能以增强抗肿瘤T细胞疗法
Alberto G Conti,Alexander C Evans,Teresa von Linde et al.
Alberto G Conti et al.
Adoptive T cell therapies are limited by poor persistence of transferred cells. Attempts to enhance persistence have focused on genetic induction of constitutively hyperactivated but potentially oncogenic T cell states. Physiological T cell...
BACH2 regulates T cell lineage state to enhance CAR T cell function [0.03%]
BACH2通过调节T细胞的发育状态来增强CAR-T的功能
Tien-Ching Chang,Amanda Heard,John Lattin et al.
Tien-Ching Chang et al.
Nearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as 'tonic signaling'. Tonic signaling of CARs containing 41BB domains enhances T cell fitness and function, in contrast to the exhaustion driven by C...
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function [0.03%]
人类E3泛素连接酶CBL在体液中的缺陷影响了白细胞中B细胞但不是T细胞的发育和功能
Taja Vatovec,Anna-Lena Neehus,Katherine J L Jackson et al.
Taja Vatovec et al.
The E3 ubiquitin ligase Casitas B-lineage lymphoma (CBL) promotes positive selection and antigen responses in mouse T lymphocytes by ubiquitinating ZAP70. Conversely, mouse CBL and CBL-B mutually redundantly regulate SYK ubiquitination and ...
A GDF-15-GFRAL axis controls autoimmune T cell responses during neuroinflammation [0.03%]
GDF-15-GFRAL轴在神经炎症期间调控自身免疫T细胞反应
Jana K Sonner,Audrey Kahn,Lars Binkle-Ladisch et al.
Jana K Sonner et al.
Inflammatory activity during multiple sclerosis (MS) often improves during pregnancy, suggesting that pregnancy-related immune adaptations affect the disease. Here we show that growth/differentiation factor-15 (GDF-15) increases during preg...
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis [0.03%]
成纤维细胞TGFβ信号的空间构型是类风湿性关节炎治疗抗性的基础
Kartik Bhamidipati,Alexa B R McIntyre,Shideh Kazerounian et al.
Kartik Bhamidipati et al.
Treatment-refractory rheumatoid arthritis (RA) is a major unmet need, and the underlying mechanisms are poorly understood. To identify molecular determinants of refractory RA, we performed spatial transcriptomic profiling on synovial tissue...
Metabolic adaptation in CD4+ T cells promotes immunosuppression in sepsis [0.03%]
CD4+t细胞的代谢适应促进脓毒症中的免疫抑制作用
Nicole M Chapman,Hongbo Chi
Nicole M Chapman
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis [0.03%]
代谢适应以亚群特异性的方式在人类危重症伴或不伴有脓毒症中重塑CD4+T细胞
Matthew T Stier,Allison E Sewell,Erin L Mwizerwa et al.
Matthew T Stier et al.
Metabolic and immunologic dysfunction, including pathological CD4+ T cell immunosuppression, are archetypal in critical illness, but whether these factors are mechanistically linked remains incompletely defined. Here we characterized the me...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID [0.03%]
独特单核细胞转录本与长新冠患者的系统免疫失调和肺部损伤有关
Saumya Kumar,Chaofan Li,Liang Zhou et al.
Saumya Kumar et al.
The mechanisms driving immune dysregulation in long COVID disease remain elusive. Here we integrated single-cell multiome data, immunological profiling and functional assays to investigate immune alterations across multiple cohorts. A trans...
Annukka A R Antar,Elizabeth C Pasetes,Kay&#x;La M Z Brennon et al.
Annukka A R Antar et al.