Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates [0.03%]
一种非人灵长类动物模型快速激发针对HIV-1_env的V3-N糖抗体（中和且与天冬酰胺332糖基无关）
Ignacio Relano-Rodriguez,Jianqiu Du,Zi Jie Lin et al.
Ignacio Relano-Rodriguez et al.
Sequential immunization is a promising approach to elicit broadly neutralizing antibodies (bNAbs) against the HIV-1 Envelope (Env). However, available protocols are inefficient and involve multiple immunizations over long periods of time. H...
Stephanie Houston
Stephanie Houston
Impairing FRC conduits [0.03%]
损害FRC通道
Laurie A Dempsey
Laurie A Dempsey
One eye on cytokines [0.03%]
警惕细胞因子风暴
Nicholas J Bernard
Nicholas J Bernard
Plastic microglia [0.03%]
塑料小胶质细胞理论
Ioana Staicu
Ioana Staicu
Publisher Correction: Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury [0.03%]
出版更正：淋巴毒素依赖性升高的脑膜CXCL13：BAFF比率驱动灰质损伤
Ikbel Naouar,Andrei Pangan,Michelle Zuo et al.
Ikbel Naouar et al.
Published Erratum
Nature immunology. 2026 Jan 30. DOI:10.1038/s41590-026-02442-5 2026
Shirley Le,Nick Dooley,Declan Murphy et al.
Shirley Le et al.
Dendritic cells (DCs) are pivotal for initiating adaptive immunity, a process triggered by the activation of DCs via pathogen products or damage. Immunization with sporozoites from Plasmodium leads to CD8+ T cell priming in a response initi...
SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling [0.03%]
SIRT2介导的LCK去乙酰化调控T细胞受体信号强度
Imene Hamaidi,Pingyan Cheng,Soo Young Jun et al.
Imene Hamaidi et al.
T cell receptor (TCR) signaling is precisely tuned to prevent self-reactivity while allowing protective immunity. Here we found that acetylation modulated TCR signaling. The loss of SIRT2 deacetylase activity in T cells led to amplified cal...
CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation [0.03%]
CD38使局部抗原特异的Treg细胞具有应激耐受性以控制中枢神经系统的隔室炎症反应
Hsin-Hsiang Chen,Sofia Tyystjärvi,Diego Ruiz Navarro et al.
Hsin-Hsiang Chen et al.
Foxp3-expressing regulatory T (Treg) cells protect against systemic autoimmunity. However, little is known about the significance of Treg cells in inflammation-experienced tissues. Here, we use an experimental autoimmune encephalomyelitis m...