Author Correction: Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire [0.03%]
作者更正：胸腺细胞中年龄依赖性的Zap70表达调节新生儿调节性T细胞谱系的选择
Brian D Stadinski,Elizabeth A Mills,Preston A Humphries et al.
Brian D Stadinski et al.
Published Erratum
Nature immunology. 2026 Feb 19. DOI:10.1038/s41590-026-02469-8 2026
Author Correction: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization [0.03%]
作者更正：通过吞噬体的不稳定状态硅酸盐和铝激活NLP3炎性小体
Veit Hornung,Franz Bauernfeind,Annett Halle et al.
Veit Hornung et al.
Published Erratum
Nature immunology. 2026 Feb 19. DOI:10.1038/s41590-026-02468-9 2026
Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice [0.03%]
游离素蛋白的磷酸化调控辅助性CD4+T细胞和细胞毒性CD8+T细胞的命运决定
Chihiro Ogawa,Kazuki Okuyama,Satoshi Kojo et al.
Chihiro Ogawa et al.
MHC-I- and MHC-II-selected CD4+CD8+ precursor thymocytes differentiate into cytotoxic CD8+ and helper CD4+ lineage T cells, during which suppression of Cd4 and Thpok genes by Runx-dependent-silencers in those genes is crucial to segregate t...
Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling [0.03%]
健康儿童骨髓单细胞多组学图谱揭示了由基质信号传导驱动的年龄依赖性系别分化差异
Evelyn S Hanemaaijer,Konradin F Müskens,Ireen J Kal et al.
Evelyn S Hanemaaijer et al.
Childhood is a critical period for hematopoietic development and susceptibility to hematologic disease. Here we generated a multimodal single-cell atlas of healthy human bone marrow, capturing mRNA and surface protein expression in 90,710 c...
Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses [0.03%]
人群和遗传因素塑造了人类针对病毒的抗体谱系特异性
Axel Olin,Christian Pou,Anthony Jaquaniello et al.
Axel Olin et al.
Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses has been lacking. Here ...
BACH2 the future [0.03%]
BACH2：未来版
Rajshekhar Alli,Ben Youngblood
Rajshekhar Alli
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes [0.03%]
Flt3L介导的肿瘤cDC1扩增通过淋巴结内干细胞样CD8+T细胞活化增强免疫疗法
Junyun Lai,Cheok Weng Chan,Jesse D Armitage et al.
Junyun Lai et al.
Immune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigoration of T cell responses. T cell differentiation status controls response, with less differentiated cells having an enhanced capacity to proliferate after ICB....
2'-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity [0.03%]
2'-O-甲基鸟苷核糖片断通过拮抗TLR7和TLR8来限制自身免疫反应
Arwaf S Alharbi,Sunil Sapkota,Zhikuan Zhang et al.
Arwaf S Alharbi et al.
Recognition of RNA fragments by Toll-like receptor 7 (TLR7) and TLR8 helps to initiate the innate immune response against pathogens. An outstanding question is why RNA fragments generated during clearance of apoptotic cells fail to activate...