Stephanie Houston
Stephanie Houston
Platelet tales [0.03%]
血小板的故事
Laurie A Dempsey
Laurie A Dempsey
Pro-tumor neural pathways [0.03%]
促肿瘤神经通路
Ioana Staicu
Ioana Staicu
Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation [0.03%]
Sparcl1通过抑制淋巴管生成介导的TLS形成来缓解腹主动脉瘤
Mei-Hua Chen,Yi-Jie Hua,Yan Li et al.
Mei-Hua Chen et al.
Vascular tissue-resident macrophages (VRMs) maintain immune balance in blood vessels, but their role in abdominal aortic aneurysm (AAA) development remains unclear. Here we demonstrated that a specific group of VRMs located in the adventiti...
TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology [0.03%]
TOX促进CD4+TH1效应功能、抗肿瘤免疫和自身免疫病理学
Brianna Naizir,Andrew C Scott,Paul Zumbo et al.
Brianna Naizir et al.
TOX is a nuclear factor critical for thymic development of CD4+ thymocytes, natural killer and innate lymphoid cells. In post-thymic antigen-specific CD8+ T cells, TOX is highly expressed in settings of chronic antigen encounter such as can...
Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity [0.03%]
成纤维细胞-巨噬细胞平衡调控的互惠调节维持皮肤稳态
Apple Cortez Vollmers,Sunny Z Wu,Anthony Altieri et al.
Apple Cortez Vollmers et al.
Fibroblast-macrophage crosstalk is well-established in vitro, and fibroblast-derived colony-stimulating factor 1 (CSF1) supports macrophages in select tissues. However, whether macrophages regulate fibroblasts in vivo remains unknown. Lever...
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation [0.03%]
淋巴细胞源性胆碱能通路调节生发中心的输出和B细胞活化
Duygu Nechanitzky,Logan K Smith,Robert Nechanitzky et al.
Duygu Nechanitzky et al.
Germinal centers (GCs) are specialized lymphoid structures in which activated B cells undergo clonal selection and B cell receptor (BCR) somatic hypermutation to generate high-affinity antibodies. Previous work has shown that T cells expres...
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory [0.03%]
类似 naive 细胞的代谢静止状态决定了抗原特异性记忆 T细胞的产生和维持
Sina Frischholz,Ev-Marie Schuster,Myriam Grotz et al.
Sina Frischholz et al.
Metabolic activity shapes cell fate but remains challenging to capture in vivo with high resolution. Here we performed longitudinal metabolic and phenotypic profiling of human antigen-specific CD8+ T cells after yellow fever vaccination usi...
The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas [0.03%]
结核病肉芽肿中细胞组织和细菌控制的免疫代谢分布
Erin F McCaffrey,Alea C Delmastro,Isobel Fitzhugh et al.
Erin F McCaffrey et al.
Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. Human TB granulomas are enriched for immunosupp...