Bingfei Yu,Howard Y Chang
Bingfei Yu
Genes encoding long noncoding RNAs (lncRNAs) are intimately involved in mammalian immunity. Here we review recent knowledge of how lncRNAs regulate immune cell specification and function. Beyond canonical roles in nuclear architecture, chro...
Stephanie Houston
Stephanie Houston
Paula Jauregui
Paula Jauregui
Stemness for HIV control [0.03%]
干细胞特性与HIV控制力
Nicholas J Bernard
Nicholas J Bernard
Oxidative damage [0.03%]
氧化损伤
Ioana Staicu
Ioana Staicu
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity [0.03%]
死亡细胞相关抗原的交叉呈现塑造了肿瘤免疫的新抗原景观
Kok Haw Jonathan Lim,Oliver Schulz,Irene Lobon et al.
Kok Haw Jonathan Lim et al.
Type 1 conventional dendritic cells (cDC1s) acquire and cross-present tumor antigens to prime CD8⁺ T cells. Whether this selects for specific neoantigens is unclear. DNGR-1 (CLEC9A), a cDC1 receptor for F-actin exposed on dead cells, promo...
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints [0.03%]
由皮肤衍生的髓系前体细胞和关节驻留成纤维细胞介导的银屑病从皮肤到关节的扩展
Maria G Raimondo,Hashem Mohammadian,Mario R Angeli et al.
Maria G Raimondo et al.
Psoriatic disease initially affects the skin and later extends to the joints. Here, we show a two-step process that orchestrates the spread of inflammation from the skin to the joints. Induction of psoriatic skin disease in photoconvertible...
J Magarian Blander,Atimukta Jha
J Magarian Blander
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors [0.03%]
抗原反应性界定肿瘤中的组织驻留记忆T细胞和衰竭T细胞
Thomas N Burn,Jan Schröder,Luke C Gandolfo et al.
Thomas N Burn et al.
CD8+ T cells are an important weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognoses, the tumor microenvironment also con...
Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease [0.03%]
组织驻留耗竭性和记忆性CD8⁺ T细胞具有不同的发生、功能和在疾病中的作用
Simone L Park,Mark M Painter,Sasikanth Manne et al.
Simone L Park et al.
The presence of CD8+ T cells coexpressing residency and exhaustion molecules in chronic diseases often correlate with clinical outcomes; however, the relationship between these cells and conventional tissue-resident memory (TRM) cells or ex...