Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection [0.03%]
感染期间CD4⁺ T细胞的组织特异性克隆选择和分化
Roham Parsa,Helder C Assis,Tiago B R de Castro et al.
Roham Parsa et al.
Pathogen-specific CD4⁺ T cells expand and contract during infection, generating memory clones that shape subsequent immune responses. How distinct tissue environments influence differentiation and clonal selection of polyclonal T cells rem...
Marleen Bérouti,Veit Hornung
Marleen Bérouti
Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection [0.03%]
XKR8诱导脂质不对称性破坏调控中性粒细胞胞外陷阱形成并抑制真菌感染
Weixiang Liu,Jieming Ping,Lishan Deng et al.
Weixiang Liu et al.
Neutrophil extracellular traps (NETs) constitute a vital antimicrobial defense mechanism of neutrophils, contributing to various physio-pathological processes; however, the role of plasma membrane asymmetry in this process remains unknown. ...
HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease [0.03%]
人类白细胞抗原I类信号肽变异预测NKG2A+NK细胞对缺失自我信号的反应强度及人类疾病风险
Zhansong Lin,Arman A Bashirova,Cian Callahan et al.
Zhansong Lin et al.
Natural killer (NK) cells expressing inhibitory receptors that recognize self human leukocyte antigen (HLA) class I molecules gain enhanced functionality-a process influenced by genetic polymorphism that dictates the strength of interaction...
Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells [0.03%]
肺基质细胞初始免疫交叉调节和表观遗传记忆介导的蛋白酶敏感性长期抑制作用
Jaechan Ryu,Amy Blondeau,Olivier Mirabeau et al.
Jaechan Ryu et al.
Prevention and regulation of excessive inflammation is a key target to protect against inflammatory pathologies such as autoimmunity and allergy. In a mouse model of acute lung protease hypersensitivity, we assessed the efficacy of immunolo...
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control [0.03%]
自身中和抗体和多效性T细胞有助于长期HIV-1干预后的控制作用
Katie Fisher,Mauro A Garcia,Giacomo S Frattari et al.
Katie Fisher et al.
Antiretroviral therapy (ART) interruption typically leads to rapid HIV-1 viral rebound in people with HIV-1. To develop an HIV-1 cure, insight into immunological mechanisms capable of preventing HIV-1 viral rebound is urgently needed. Here,...
Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity [0.03%]
排除Notch在摄取凋亡细胞过程中的接触位点以限制抗癌免疫反应
Zhenrui Li,Beisi Xu,Piyush Sharma et al.
Zhenrui Li et al.
The clearance of dying cells by phagocytes (efferocytosis) is important for maintenance of tissue homeostasis and the active repression of inflammatory responses but can promote an immunosuppressive tumor microenvironment. Here we show that...
Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging [0.03%]
Piezo1依赖的基质细胞活化点燃运动和损伤中的肌肉炎症并与衰老相关炎症有关
P Kent Langston,Jayashree Vijaya Raghavan,Christophe Benoist et al.
P Kent Langston et al.
As the actuator of movement and a key regulator of organismal metabolism, skeletal muscle is a site at which inflammatory responses must be carefully calibrated to counteract stressors while preventing protracted functional impairments. Exe...
A pro-DC3 Trojan horse [0.03%]
一种支持DC3木马病毒
Nicholas J Bernard
Nicholas J Bernard