Marta Garo-Pascual,Linda Zhang,Meritxell Valentí-Soler et al.
Marta Garo-Pascual et al.
Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable. In a sample of 64 superagers (mean age, 81.9; 59% women) and 55 typical older a...
Evidence for Two Subpopulations of Cerebrospinal Fluid-Contacting Neurons with Opposite GABAergic Signaling in Adult Mouse Spinal Cord [0.03%]
关于成人鼠脊髓中具有相反的GABA信号的脑脊液接触神经元亚群的证据
Priscille Riondel,Nina Jurčić,Lourdes Mounien et al.
Priscille Riondel et al.
Spinal cerebrospinal fluid-contacting neurons (CSF-cNs) form an evolutionary conserved bipolar cell population localized around the central canal of all vertebrates. CSF-cNs were shown to express molecular markers of neuronal immaturity int...
Adaptive Responding to Stimulus-Outcome Associations Requires Noradrenergic Transmission in the Medial Prefrontal Cortex [0.03%]
中前额叶皮层去甲肾上腺素能传递适应刺激-结果关联反应的必要性
Alessandro Piccin,Hadrien Plat,Mathieu Wolff et al.
Alessandro Piccin et al.
A dynamic environment, such as the one we inhabit, requires organisms to continuously update their knowledge of the setting. While the prefrontal cortex is recognized for its pivotal role in regulating such adaptive behavior, the specific c...
Taekjun Kim,Anitha Pasupathy
Taekjun Kim
Visual crowding refers to the phenomenon where a target object that is easily identifiable in isolation becomes difficult to recognize when surrounded by other stimuli (distractors). Many psychophysical studies have investigated this phenom...
Computational Mechanisms Underlying Motivation to Earn Symbolic Reinforcers [0.03%]
计算机制的动机机制以获得象征性强化物
Diana C Burk,Craig Taswell,Hua Tang et al.
Diana C Burk et al.
Reinforcement learning is a theoretical framework that describes how agents learn to select options that maximize rewards and minimize punishments over time. We often make choices, however, to obtain symbolic reinforcers (e.g., money, point...
40 Hz Steady-State Response in Human Auditory Cortex Is Shaped by Gabaergic Neuronal Inhibition [0.03%]
人耳蜗皮层的40 Hz稳态反应受GABA能神经元抑制的影响
Alessandro Toso,Annika P Wermuth,Ayelet Arazi et al.
Alessandro Toso et al.
The 40 Hz auditory steady-state response (ASSR), an oscillatory brain response to periodically modulated auditory stimuli, is a promising, noninvasive physiological biomarker for schizophrenia and related neuropsychiatric disorders. The 40 ...
Novel Electrophysiological Signatures of Learning and Forgetting in Human Rapid Eye Movement Sleep [0.03%]
人类快速眼动睡眠中新颖的学习和遗忘电生理标志
Alessandra E Shuster,Pin-Chun Chen,Hamid Niknazar et al.
Alessandra E Shuster et al.
Despite the known behavioral benefits of rapid eye movement (REM) sleep, discrete neural oscillatory events in human scalp electroencephalography (EEG) linked with behavior have not been discovered. This knowledge gap hinders mechanistic un...
Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study [0.03%]
一项无威胁存在时关于人脑导水管周围灰质列状和头尾状组织的特斯拉证据的七项研究：一项工作记忆研究
Alexandra K Fischbach,Ajay B Satpute,Karen Quigley et al.
Alexandra K Fischbach et al.
The periaqueductal gray (PAG) is a small midbrain structure that surrounds the cerebral aqueduct, regulates brain-body communication, and is often studied for its role in "fight-or-flight" and "freezing" responses to threat. We used ultra-h...
Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development [0.03%]
左旋多巴诱导的运动障碍发展过程中直接通路纹状体神经元的不同激活状态
David A Figge,Henrique de Amaral Oliveira,Jack Crim et al.
David A Figge et al.
l-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine (DA) replacement therapy with l-DOPA for the treatment of Parkinson's disease. LID is associated with supersensitivity of striatal dopaminergi...
Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP [0.03%]
钙离子依赖的神经元兴奋性调节功能在脆性X染色体综合征中被Tat连接的FMRP N端片段所挽救
Xiaoqin Zhan,Hadhimulya Asmara,Paul Pfaffinger et al.
Xiaoqin Zhan et al.
Fragile X syndrome (FXS) arises from the loss of fragile X messenger ribonucleoprotein (FMRP) needed for normal neuronal excitability and circuit functions. Recent work revealed that FMRP contributes to mossy fiber long-term potentiation by...