ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin [0.03%]
渐冻症和亨廷顿病：解开TDP-43与亨廷顿蛋白之间的联系
Cailyn M Perry,Dale D O Martin
Cailyn M Perry
Amyotrophic lateral sclerosis (ALS) and Huntington disease (HD) are lethal neurodegenerative diseases affecting motor function. Though their etiology and pathology are distinct, recent evidence suggests commonalities between TAR DNA-binding...
The Frontopolar Cortex Contributes to Motivating Cognitive Effort Exertion during Adaptive Decision-Making [0.03%]
额极皮层在适应性决策过程中激励认知努力的施加中起作用
Luca Bovolon
Luca Bovolon
Neuroligin-2-dependent adhesion defines a molecular checkpoint for inhibitory synaptic plasticity [0.03%]
神经粘附素-2依赖性黏附界定了抑制性突触可塑性的分子检查点
Anna Lech,Grzegorz Wiera,Jerzy W Mozrzymas
Anna Lech
Long-term regulation of inhibitory synaptic strength is crucial for maintaining excitation-inhibition (E/I) balance in cortical circuits. In this study, we identify neuroligin-2 (Nlgn2) as a critical mediator of inhibitory long-term potenti...
A spinal origin for the obligate flexor synergy in the non-human primate: Implications for control of reaching [0.03%]
非人灵长类动物脊髓起源的强制性屈肌协同运动及其对抓握控制的意义
Isabel S Glover,Anne M E Baker,John W Krakauer et al.
Isabel S Glover et al.
Stroke survivors frequently develop the flexor synergy, an obligate co-contraction of shoulder abductors and elbow flexors. The neural substrate has to date proven elusive. Here we trained two healthy female monkeys to generate isometric el...
Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease [0.03%]
先天性心脏病新生儿功能脑网络的非典型发育特征研究
Jung-Hoon Kim,Josepheen De Asis-Cruz,Nickie N Andescavage et al.
Jung-Hoon Kim et al.
Congenital heart disease (CHD) affects approximately 1% of live births in the United States and is the most prevalent congenital disorder. Despite advances in neonatal cardiovascular surgery improving survival, neurodevelopmental impairment...
GABA and Glx distinctively predict motor learning and retention in young and older adults [0.03%]
年轻和老年成年人中GABA和Glx特异性预测运动学习和保持
Geraldine Rodriguez-Nieto,Hong Li,Sima Chalavi et al.
Geraldine Rodriguez-Nieto et al.
Gamma aminobutyric acid (GABA) and glutamate are fundamental in neural plasticity. Motor learning is predicted by baseline levels of these metabolites and their modulation in the sensorimotor cortex (SM1), but less is known about the metabo...
Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice [0.03%]
异氟醚麻醉下海马中间隔核到腹侧被盖区异质性环路双向调控小鼠意识状态及其机制研究
Jia-Yi Wu,Chi Cui,Xin-Yi Dai et al.
Jia-Yi Wu et al.
General anesthesia (GA) induces reversible unconsciousness for surgery, yet mechanisms underlying bidirectional transitions of states of consciousness during GA remain largely unknown. Here, we focused on states of consciousness, rather tha...
Increased and coupled ERP and fMRI responses towards positive social evaluative feedback: An EEG-fMRI study [0.03%]
正向社交评价反馈下事件相关电位和血氧水平功能磁共振的增强及耦合：一项EEG-fMRI研究
Antje Peters,Kim Weiss,Hanne Helming et al.
Antje Peters et al.
Social evaluative feedback is a key component of human social interaction, influencing self-view, behavior, and psychological well-being. This study investigates the neural mechanisms underlying social feedback processing in relation to sel...
Temporally coordinated activity among motor cortex, thalamus, and thalamic reticular nucleus neurons during rat forelimb movements [0.03%]
大鼠前肢运动期间运动皮层、丘脑和丘脑网状核神经元的时空协同活动规律研究
Mariko Sunahara,Alain Rios,Masanori Kawabata et al.
Mariko Sunahara et al.
Thalamic reticular nucleus (TRN) neurons receive excitatory inputs from both cortical and thalamic neurons, and, in turn, inhibit thalamic relay neurons, thereby modulating thalamocortical signaling. Recent studies suggested that the TRN in...
Listening to a consonant chord progression during live face-to-face gaze enhances neural activity in social systems [0.03%]
在面对面注视下聆听协和和弦进程可增强社交神经系统活动
Dash A Watts,Aza Stephen Allsop,Simone Compton et al.
Dash A Watts et al.
Although music has been associated with increased pro-social behavior, the underlying mechanisms for music-facilitated social benefits are not known. We test the hypothesis that chord progressions promote social bonding between dyads by sha...