Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex [0.03%]
灵长类前扣带皮层胆碱能调控的环路特异性神经解剖学基底
Alexandra Tsolias,Yuxin Zhou,Chromewell A Mojica et al.
Alexandra Tsolias et al.
Acetylcholine is a robust neuromodulator of the limbic system and a critical regulator of arousal and emotions. The anterior cingulate cortex (ACC) and the amygdala (AMY) are key limbic structures that are both densely innervated by choline...
Vagus Nerve Stimulation (VNS) Modulates Synaptic Plasticity in the Infralimbic Cortex via Trk-B Receptor Activation to Reduce Drug-Seeking in Male Rats [0.03%]
迷走神经刺激通过Trk-B受体激活调节腹侧前扣带回脑区的突触可塑性从而减少成年雄性大鼠的毒品寻求行为
Christopher M Driskill,Jessica E Childs,Aarron J Phensy et al.
Christopher M Driskill et al.
Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction le...
CCK+ Interneurons Contribute to Thalamus-Evoked Feed-Forward Inhibition in the Prelimbic Prefrontal Cortex [0.03%]
顶核诱导的前额叶皮层内侧 feed-forward 抑制过程中 CCK阳性中间神经元的作用
Aichurok Kamalova,Kasra Manoocheri,Xingchen Liu et al.
Aichurok Kamalova et al.
Interneurons in the medial prefrontal cortex (PFC) regulate local neural activity to influence cognitive, motivated, and emotional behaviors. Parvalbumin-expressing (PV+) interneurons are the primary mediators of thalamus-evoked feed-forwar...
Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons [0.03%]
特定压力引起的室间隔SARM1活化及皮层神经元局部退行性变
Flora I Hinz,Carmela Louise M Villegas,Jasmine T Roberts et al.
Flora I Hinz et al.
Sterile alpha and TIR motif containing 1 (SARM1) is an inducible NADase that localizes to mitochondria throughout neurons and senses metabolic changes that occur after injury. Minimal proteomic changes are observed upon either SARM1 depleti...
Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development [0.03%]
FUS蛋白的突变影响轴突的发育
Francesca W van Tartwijk,Lucia C S Wunderlich,Ioanna Mela et al.
Francesca W van Tartwijk et al.
Aberrant condensation and localization of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with ...
TMS-fMRI Supports Roles for VLPFC and Downstream Regions in Cognitive Reappraisal [0.03%]
TMS-fMRI支持VLPFC和下游区域在认知再评价中的作用
Malvika Sridhar,Azeezat Azeez,Jennifer I Lissemore
Malvika Sridhar
Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons [0.03%]
髓鞘轴突中细胞外电流流动对动作电位传播的影响
Nooshin Abdollahi,Steven A Prescott
Nooshin Abdollahi
Myelinated axons conduct action potentials, or spikes, in a saltatory manner. Inward current caused by a spike occurring at one node of Ranvier spreads axially to the next node, which regenerates the spike when depolarized enough for voltag...
Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo [0.03%]
Tbx2在多个年龄体内将外毛细胞转化为内毛细胞的潜能再评估
Zhenghong Bi,Minhui Ren,Yu Zhang et al.
Zhenghong Bi et al.
The mouse auditory organ cochlea contains two types of sound receptors: inner hair cells (IHCs) and outer hair cells (OHCs). Tbx2 is expressed in IHCs but repressed in OHCs, and neonatal OHCs that misexpress Tbx2 transdifferentiate into IHC...
Connected in Bad Times and in Good Times: Empathy Induces Stable Social Closeness [0.03%]
同舟共济：同情促进稳定的社会亲密感
Anne Saulin,Chih-Chung Ting,Jan B Engelmann et al.
Anne Saulin et al.
Humans need social closeness to prosper. There is evidence that empathy can induce social closeness. However, it remains unclear how empathy-related social closeness is formed and how stable it is as time passes. We applied an acquisition-e...
Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses [0.03%]
Latrophilin-1粘附G蛋白偶联受体纳米簇在抑制性突触中的重要作用
Daniel Matúš,Jaybree M Lopez,Richard C Sando et al.
Daniel Matúš et al.
Latrophilin-1 (Lphn1, aka CIRL1 and CL1; gene symbol Adgrl1) is an adhesion GPCR that has been implicated in excitatory synaptic transmission as a candidate receptor for α-latrotoxin. Here we analyzed conditional knock-in/knock-out mice fo...