Cell- and pathway-specific disruptions in the accumbens of Fragile X mouse [0.03%]
fragile X模型小鼠中壳神经元和通路的特异性紊乱
Gabriele Giua,Jessica Pereira-Silva,Alba Caceres-Rodriguez et al.
Gabriele Giua et al.
Fragile X syndrome (FXS) is a genetic cause of intellectual disability and autism spectrum disorder (ASD), associated with social deficits. The mesocorticolimbic system, which includes the prefrontal cortex (PFC), basolateral amygdala (BLA)...
Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis [0.03%]
激活TREM2抗体在阿尔茨海默病和多发性硬化症的临床前模型中产生中立或不利效应
Ainhoa Etxeberria,Yun-An A Shen,Stephen Vito et al.
Ainhoa Etxeberria et al.
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist anti...
Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-β42 Accumulation [0.03%]
去甲肾上腺素驱动的睡眠片段化激活天冬酰胺内肽酶，蓝斑神经元变性及海马区淀粉样蛋白-β42聚集
Kathy Zhang,Yan Zhu,Polina Fenik et al.
Kathy Zhang et al.
Chronic sleep disruption (CSD), from insufficient or fragmented sleep and is an important risk factor for Alzheimer's disease (AD). Underlying mechanisms are not understood. CSD in mice results in degeneration of locus ceruleus neurons (LCn...
Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation [0.03%]
Rab6介导的突触前囊泡前体极性运输对于神经元极化和大脑形成至关重要
Yu Zhang,Masataka Kunii,Manabu Taniguchi et al.
Yu Zhang et al.
Neurons are highly polarized cells that are composed of a single axon and multiple dendrites. Axon-dendrite polarity is essential for proper tissue formation and brain functions. Intracellular protein transport plays an important role in th...
Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice [0.03%]
结节性神经节发育的分子特征揭示了小鼠中一类新的Phox2b阳性胶质前体细胞
Elijah D Lowenstein,Aristotelis Misios,Sven Buchert et al.
Elijah D Lowenstein et al.
The vagal ganglia, comprised of the superior (jugular) and inferior (nodose) ganglia of the vagus nerve, receive somatosensory information from the head and neck or viscerosensory information from the inner organs, respectively. Development...
N-Methyl-D-Aspartate Receptor-Antibody Encephalitis Impairs Maintenance of Attention to Items in Working Memory [0.03%]
N-甲基-D-天冬氨酸受体抗体脑炎会损害工作记忆中项目的注意力维持能力
Afrose Dor,Corin Harrison,Sarosh R Irani et al.
Afrose Dor et al.
NMDA receptors (NMDARs) may be crucial to working memory (WM). Computational models predict that they sustain neural firing and produce associative memory, which may underpin maintaining and binding information, respectively. We test this i...
Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation [0.03%]
单侧聋患者双耳线索的分离表征及其对 cochlear implant 置入术的影响
Peter Hubka,Leonard Schmidt,Jochen Tillein et al.
Peter Hubka et al.
Congenital single-sided deafness (SSD) leads to an aural preference syndrome that is characterized by overrepresentation of the hearing ear in the auditory system. Cochlear implantation (CI) of the deaf ear is an effective treatment for SSD...
Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex [0.03%]
跨突触的囊泡锌转运蛋白3和Shank3支持小鼠听皮层特定突触的树突棘结构与功能
Abbey Manning,Philip T R Bender,Helen Boyd-Pratt et al.
Abbey Manning et al.
Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The localization of Shank3 at excitatory synapses and the ...
The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer's Disease [0.03%]
认知障碍的网络结构：从主观认知衰退到阿尔茨海默病
Giorgia Tosi,Salvatore Nigro,Daniele Urso et al.
Giorgia Tosi et al.
It was proposed that a reorganization of the relationships between cognitive functions occurs in dementia, a vision that surpasses the idea of a mere decline of specific domains. The complexity of cognitive structure, as assessed by neurops...
Populations of hindbrain glucagon-like peptide 1 (GLP1) neurons that innervate the hypothalamic PVH, thalamic PVT, or limbic forebrain BST have axon collaterals that reach all central regions innervated by GLP1 neurons [0.03%]
后脑胰高血糖素样肽1(GLP1)神经元的群体可投射至下丘脑室旁核(PVH)、丘脑腹中间核(PVT)或边缘前脑 BST,其轴突侧支可到达GLP1 神经元投射的所有中枢区域
Abigail B Randolph,Huiyuan Zheng,Linda Rinaman
Abigail B Randolph
Neurons in the caudal nucleus of the solitary tract (cNTS) and intermediate reticular nucleus (IRt) that express the glucagon gene (Gcg) give rise to GLP1-immunopositive axons in the spinal cord and many subcortical brain regions. Central G...