G272V and P301L Mutations Induce Isoform Specific Tau Mislocalization to Dendritic Spines and Synaptic Dysfunctions in Cellular Models of 3R and 4R Tau Frontotemporal Dementia [0.03%]
G272V 和 P301L 突变诱导tau蛋白亚型特异性错定位至细胞模型中 3R 和 4R tau 型额颞叶痴呆的突触功能障碍
Ke Yu,Katherine R Yao,Miguel A Aguinaga et al.
Ke Yu et al.
Tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including Alzheimer's disease (AD), Lewy body dementia (LBD), chronic traumatic encephalopathy (CTE), and frontotemporal dementia (FTD). Tau pr...
Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI [0.03%]
基于弥散磁共振成像的胎儿大脑皮层结构网络第二至第三孕期发育研究
Ruike Chen,Ruoke Zhao,Haotian Li et al.
Ruike Chen et al.
During the second-to-third trimester, the neuronal pathways of the fetal brain experience rapid development, resulting in the complex architecture of the interwired network at birth. While diffusion MRI-based tractography has been employed ...
Cerebral grey matter may not explain sleep slow-wave characteristics after severe brain injury [0.03%]
脑灰质可能无法解释严重脑损伤后的睡眠慢波特征
Narges Kalantari,Véronique Daneault,Hélène Blais et al.
Narges Kalantari et al.
Sleep slow waves are the hallmark of deeper non-rapid eye movement sleep. It is generally assumed that grey matter properties predict slow-wave density, morphology, and spectral power in healthy adults. Here, we tested the association betwe...
Xi Chen,Swati Gupta,Simone Russo et al.
Xi Chen et al.
Bradley G Karat,Stefan Köhler,Ali R Khan
Bradley G Karat
The hippocampus is a brain structure that plays key roles in a variety of cognitive processes. Critically, a wide range of neurological disorders are associated with degeneration of the hippocampal microstructure, defined as neurons, dendri...
Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles [0.03%]
AMPAC受体纳米域诞生日记——以10纳 candles的亮度照亮兴奋性突触的纳米尺度组织结构
Yuko Fukata,Masaki Fukata,Harold D MacGillavry et al.
Yuko Fukata et al.
A decade ago, in 2013, and over the course of 4 summer months, three separate observations were reported that each shed light independently on a new molecular organization that fundamentally reshaped our perception of excitatory synaptic tr...
Brain network interconnectivity dynamics explain metacognitive differences in listening behavior [0.03%]
脑网络互联动力学解释了聆听行为中的元认知差异
Mohsen Alavash,Jonas Obleser
Mohsen Alavash
Complex auditory scenes pose a challenge to attentive listening, rendering listeners slower and more uncertain in their perceptual decisions. How can we explain such behaviors from the dynamics of cortical networks that pertain to the contr...
Speech Prosody Serves Temporal Prediction of Language via Contextual Entrainment [0.03%]
语境同步理论下的言语节律促进语言的时间预测作用
Yulia Lamekina,Lorenzo Titone,Burkhard Maess et al.
Yulia Lamekina et al.
Temporal prediction assists language comprehension. In a series of recent behavioral studies, we have shown that listeners specifically employ rhythmic modulations of prosody to estimate the duration of upcoming sentences, thereby speeding ...
Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses [0.03%]
磷脂 scramblase 1 控制小脑突触神经传递的效率和囊泡回收
Margherita Caputo,Daniela Ivanova,Sylvette Chasserot-Golaz et al.
Margherita Caputo et al.
Phospholipids (PLs) are asymmetrically distributed at the plasma membrane. This asymmetric lipid distribution is transiently altered during calcium-regulated exocytosis, but the impact of this transient remodeling on presynaptic function is...