Constitutive and conditional epitope-tagging of endogenous G protein coupled receptors in Drosophila [0.03%]
果蝇内源性G蛋白偶联受体的组成型和诱导型表位标记
Shivan L Bonanno,Piero Sanfilippo,Aditya Eamani et al.
Shivan L Bonanno et al.
To visualize the cellular and subcellular localization of neuromodulatory G-protein coupled receptors (GPCRs) in Drosophila, we implement a molecular strategy recently used to add epitope tags to ionotropic receptors at their endogenous loc...
Characterization of mice carrying a neurodevelopmental disease-associated GluN2B(L825V) variant [0.03%]
携神经系统发育疾病相关GluN2B(L825V)突变小鼠的特征分析
Miriam Candelas Serra,Viktor Kuchtiak,Agnieszka Kubik-Zahorodna et al.
Miriam Candelas Serra et al.
N-methyl-D-aspartate receptors (NMDARs), encoded by GRIN genes, are ionotropic glutamate receptors playing a critical role in synaptic transmission, plasticity, and synapse development. Genome sequence analyses have identified variants in G...
Astrocytes modulate a specific paraventricular thalamus-prefrontal cortex projection to enhance consciousness recovery from anesthesia [0.03%]
星形胶质细胞通过调节特异的室周核-前额叶回路促进麻醉后意识恢复
Yi Zhao,Mengchan Ou,Jin Liu et al.
Yi Zhao et al.
Current anesthetic theory is mostly based on neurons and/or neuronal circuits. A role for astrocytes also has been shown in promoting recovery from volatile anesthesia, while the exact modulatory mechanism and/or the molecular target in ast...
Segmenting and Predicting Musical Phrase Structure Exploits Neural Gain Modulation and Phase Precession [0.03%]
利用神经增益调制和相位预热进行音乐短语结构的分割和预测
Xiangbin Teng,Pauline Larrouy-Maestri,David Poeppel
Xiangbin Teng
Music, like spoken language, is often characterized by hierarchically organized structure. Previous experiments have shown neural tracking of notes and beats, but little work touches on the more abstract question: how does the brain establi...
Devyn E Smith,Nicole M Long
Devyn E Smith
Engaging the retrieval state (Tulving, 1983) impacts processing and behavior (Long & Kuhl, 2019, 2021; Smith, Moore, & Long, 2022), but the extent to which top-down factors - explicit instructions and goals -vs. bottom-up factors - stimulus...
Cognitive Control and Neural Activity during Human Development: Evidence for Synaptic Pruning [0.03%]
认知控制与人类发育过程中的神经活动：突触修剪的证据
Leland L Fleming,Timothy J McDermott
Leland L Fleming
Molecular organization of autonomic, respiratory, and spinally-projecting neurons in the mouse ventrolateral medulla [0.03%]
小鼠延髓外侧区自主、呼吸和脊髓投射神经元的分子分类
Dana C Schwalbe,Daniel S Stornetta,Ruei-Jen Abraham-Fan et al.
Dana C Schwalbe et al.
The ventrolateral medulla (VLM) is a crucial region in the brain for visceral and somatic control, serving as a significant source of synaptic input to the spinal cord. Experimental studies have shown that gene expression in individual VLM ...
Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity [0.03%]
背侧丘脑兴奋性传导和感觉运动活动受纹脑皮质mGlu8调节
Bretton P Nabit,Anne Taylor,Danny G Winder
Bretton P Nabit
Metabotropic glutamate receptor 8 (mGlu8) is a heterogeneously expressed and poorly understood glutamate receptor with potential pharmacological significance. The thalamic reticular nucleus (TRN) is a critical inhibitory modulator of the th...
Gunnar L Quass,Meike M Rogalla,Alexander N Ford et al.
Gunnar L Quass et al.
Linking sensory input and its consequences is a fundamental brain operation. During behavior, the neural activity of neocortical and limbic systems often reflects dynamic combinations of sensory and task-dependent variables, and these "mixe...