Modulation and gating of transthalamic and subcortical pathways through somatosensory thalamus [0.03%]
躯体感觉丘脑对横贯丘脑通路和亚皮质通路的调制及门控作用
Kevin P Koster,S Murray Sherman
Kevin P Koster
Higher order (HO) thalamic nuclei are characterized by receiving driver input from layer 5 (L5) of cortex and serve as a transthalamic route of corticocortical communication. These HO nuclei are also innervated by subcortical sources. In th...
Oscar Woolnough,Tessy Thomas,Kathryn M Snyder et al.
Oscar Woolnough et al.
Our ability to retrieve the names of objects in our environment is a fundamental aspect of everyday life. This process requires a complex, dynamic network of cortical and subcortical interactions. While the cortical constituents of this net...
In vivo screen of Parkinson's disease GWAS risk genes identifies ARIH2 as a novel regulator of α-synuclein toxicity in dopaminergic neurons [0.03%]
帕金森病基因组研究风险基因的体内筛查发现ARIH2是多巴胺能神经元中α-突触核蛋白毒性的新调节因子
Maria Armakola,Anika P Wilen,Bernabe I Bustos et al.
Maria Armakola et al.
Parkinson's disease is a late onset neurodegenerative disease characterized by preferential degeneration of midbrain dopaminergic neurons and α-synuclein containing Lewy bodies that are found in both familial and sporadic forms. Genome wid...
Human Beta Oscillations Reflect Magnitude and Fidelity of Priority Shifts in Working Memory [0.03%]
人脑beta振荡反映工作记忆中优先级转换的幅度和保真度
Nicholas E Myers,Mark G Stokes,Paul S Muhle-Karbe
Nicholas E Myers
Flexible prioritisation in working memory (WM) is supported by neural oscillations in frontal and sensory brain areas, but the roles of different oscillations remain poorly understood. Recordings in humans suggest an interplay between prefr...
Auditory representation of vocal signals in a pallial cortical circuit [0.03%]
与鸣叫声信号有关的听觉皮层环路中的神经元编码研究
Tarciso A F Velho,Dan Iancu,Rêmullo Brenno Galvão de Miranda Costa et al.
Tarciso A F Velho et al.
Knowledge of how vocal communication signals are represented in the auditory system is crucial for understanding the perceptual basis of vocal communication. Using male and female zebra finches, we identified a series of differentially expr...
Controlled retrieval relies on directed interactions between semantic control regions and visual cortex: MEG evidence from oscillatory dynamics [0.03%]
控制检索依赖语义控制区和视觉皮层之间的定向交互作用：来自振荡动态的脑磁图证据
Susanne Eisenhauer,Meichao Zhang,Katya Krieger-Redwood et al.
Susanne Eisenhauer et al.
To navigate the world, we store knowledge about relationships between concepts and retrieve this information flexibly to suit our goals. The semantic control network, comprising left inferior frontal gyrus (IFG) and posterior middle tempora...
Abnormal neuronal excitability and reduced parvalbumin expression in Shank3-deficient parvalbumin neurons of the thalamic reticular nucleus [0.03%]
SHANK3缺陷对丘脑网状核PV神经元兴奋性及表达的影响
Yubo Lai,Lulu Lü,Runfeng Sun et al.
Yubo Lai et al.
Fast-spiking, non-adaptive inhibitory neurons in the thalamic reticular nucleus (TRN) critically gate the reciprocal communication between the thalamus and the cortex. Parvalbumin (PV) neurons express high levels of PV, the sole role of whi...
Environmental enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice [0.03%]
环境丰富保留了回隔区苍白素密度和五聚体5xFAD小鼠的认知功能
Dylan J Terstege,Jonathan R Epp
Dylan J Terstege
The rate of cognitive decline in Alzheimer's disease (AD) varies considerably from person to person. Numerous epidemiological studies point to the protective effects of cognitive, social, and physical enrichment as potential mediators of co...
A time-sensitive plasticity distinguishes the rapid and sustained synaptic actions of ketamine from its (2R, 6R)-hydroxynorketamine metabolite [0.03%]
时间敏感的可塑性使氯胺酮与其(2R, 6R)羟基代谢产物区分开来，从而使两者产生快速和持续的突触作用
Kyle A Brown,Patrick J Morris,Craig J Thomas et al.
Kyle A Brown et al.
(R,S)-ketamine (ketamine) induces rapid and sustained antidepressant-relevant neuroplastogenic effects in vivo. The metabolite (2R,6R)-hydroxynorketamine (2R6R) forms shortly after the administration of ketamine, and independently elicits r...
Different reliance on sensory reinstatement and internally transformed representations during vivid retrieval of visual and auditory episodes [0.03%]
在生动检索视觉和听觉片段期间，对感觉再现和内部转换表征的不同依赖性
Lei Zhang 张磊,Claude Alain,Bradley R Buchsbaum
Lei Zhang 张磊
Episodic memory retrieval engages both sensory reinstatement and internally transformed representations. Due to modality-specific processing, auditory and visual memories may differ in their reliance on these mechanisms. We used functional ...