Reduction in reward-driven behaviour depends on the basolateral but not central nucleus of the amygdala in female rats [0.03%]
奖赏驱动的行为减少依赖于杏仁核的基底外侧但不是中央杏仁核区域在雌性大鼠中
Belinda P P Lay,Guillem R Esber,Mihaela D Iordanova
Belinda P P Lay
Adaptive behavior depends on a dynamic balance between acquisition and extinction memories. Male and female rodents differ in extinction learning rates, suggestion potential sex-based differences in this balance. In males, deletion of extin...
Sphingosine-1-phosphate signaling through Müller glia regulates neuroprotection, accumulation of immune cells, and neuronal regeneration in the rodent retina [0.03%]
鞘氨醇-1-磷酸通过视网膜小胶质细胞的信号转导调节神经保护、免疫细胞积累和神经再生
Olivia Taylor,Lisa E Kelly,Heithem M El-Hodiri et al.
Olivia Taylor et al.
The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult mal...
Competition between tool and hand motion impairs movement planning in limb apraxia [0.03%]
构肢障碍患者的工具和手的动作竞争会影响运动计划
Simon Thibault,John B Yates,Laurel J Buxbaum et al.
Simon Thibault et al.
Tool use is a complex motor planning problem. Prior research suggests that planning to use tools involves resolving competition between different tool-related action representations. We therefore reasoned that competition may also be exacer...
Layer 6 corticothalamic neurons induce high gamma oscillations through cortico-cortical and cortico-thalamo-cortical pathways [0.03%]
第6层皮层丘脑神经元通过皮层间及皮层-丘脑-皮层环路诱发高γ频段振荡活动
Simone Russo,Elaida D Dimwamwa,Garrett B Stanley
Simone Russo
Layer 6 corticothalamic (L6CT) neurons project to both cortex and thalamus, inducing multiple effects including the modulation of cortical and thalamic firing, and the emergence of high gamma oscillations in the cortical local field potenti...
Large-scale color biases in the retinotopic functional architecture are region specific and shared across human brains [0.03%]
大面积的颜色偏差在视网膜拓扑功能架构中特定于脑区并在人脑间共享
Michael M Bannert,Andreas Bartels
Michael M Bannert
Despite the functional specialization in visual cortex, there is growing evidence that the processing of chromatic and spatial visual features is intertwined. While past studies focused on visual field biases in retina and behavior, large-s...
Familiarity gates socially transmitted aggression via the medial amygdala [0.03%]
熟悉性通过中杏仁核传递社会性攻击行为
Magdalene P Adjei,Elana Qasem,Sophia Aaflaq et al.
Magdalene P Adjei et al.
Aggressive behavior can be acquired through observation, providing adaptive advantages but also posing significant social risks. In humans, individuals repeatedly exposed to aggression are more likely to engage in violent behavior later in ...
PolyQ-expansion of Ataxin-2 disrupts microtubule stability and impairs axon outgrowth [0.03%]
聚Q延长的Ataxin-2破坏微管稳定性并阻碍轴突生长
Sun K Kim,Vladimir I Gelfand
Sun K Kim
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by mislocalization and aggregation of proteins in motor neurons. Ataxin-2 (ATXN2), an RNA-binding protein harboring 22-polyglutamine (polyQ) repeats, is ...
Network dysfunction precedes neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD [0.03%]
渐冻症-额颞叶痴呆Tau蛋白鼠模型中网络功能障碍先于神经退行性病变出现
William Rodemer,Irene Ra,Jaskeerat Gujral et al.
William Rodemer et al.
Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS) but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remains unclear. Emerging evidence indicates th...
Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles [0.03%]
青年成人奖赏和惩罚反应的可分离神经连接组 mapping: 与遗传变异和神经递质谱型的关联
Ting Xu,Chunhong Zhu,Xinqi Zhou et al.
Ting Xu et al.
While the hyper- and hypo- reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, the lack of an overarching neurobiological characterization currently limi...