Nandakumar S Narayanan,James M Hyman,Jeremy Seamans et al.
Nandakumar S Narayanan et al.
Nic Glewwe,Nicola M Grissom,Alik S Widge
Nic Glewwe
Deep brain stimulation (DBS) is an emerging treatment for otherwise treatment-refractory psychiatric disorders. It can produce remarkable clinical results in expert hands, but has not fared as well in controlled, multisite trials. That diff...
Stereoelectroencephalography reveals neural signatures of multisensory integration in the human superior temporal sulcus during audiovisual speech perception [0.03%]
立体脑电图揭示人脑顶下小叶在视听言语感知过程中多感觉整合的神经特征
Yue Zhang,John F Magnotti,Xiang Zhang et al.
Yue Zhang et al.
Human speech perception is multisensory, integrating auditory information from the talker's voice with visual information from the talker's face. BOLD fMRI studies have implicated the superior temporal gyrus (STG) in processing auditory spe...
Trans-synaptic interaction with mGluR6 contributes to ELFN1 presynaptic enrichment in rod photoreceptors [0.03%]
跨突触相互作用与mGluR6贡献于视杆光感受器中ELFN1的前突触富集
Jaeeun Lee,Robyn V McGowan,Melina A Agosto
Jaeeun Lee
At the glutamatergic synapses between rod photoreceptors and ON-type bipolar cells, neurotransmitter is detected by the postsynaptic metabotropic glutamate receptor mGluR6. This receptor forms trans-synaptic interactions with ELFN1, a presy...
Smg5 enhances oligodendrocyte differentiation via nonsense-mediated mRNA decay of Hnrnpl variant transcripts [0.03%]
SMG5通过加速HNRNPL变异剪接的mRNA降解促进少突胶质细胞分化
Min Jiang,Conghui Li,Binghua Xie et al.
Min Jiang et al.
Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism that degrades transcripts with premature termination codons (PTCs) and finetunes gene expression by targeting RNA transcripts with other NMD inducing features. Thi...
Social Decision Preferences for Close Others are Embedded in Neural and Linguistic Representations [0.03%]
社会决策偏好的亲密他人嵌入神经和语言表达中
João F Guassi Moreira,L Concepción Esparza,Jennifer A Silvers et al.
João F Guassi Moreira et al.
Humans frequently make decisions that impact close others. Prior research has shown that people have stable preferences regarding such decisions and maintain rich, nuanced mental representations of their close social partners. Yet, if and h...
Cholinergic dynamics in the septo-hippocampal system provide phasic multiplexed signals for spatial novelty and correlate with behavioral states [0.03%]
胆碱能动力学在隔丘脑系统中提供阶段性复用的空间新颖性信号并与其行为状态相关联
Fatemeh Farokhi Moghadam,Blanca E Gutierrez Guzman,Xihui Zheng et al.
Fatemeh Farokhi Moghadam et al.
In the hippocampal formation, cholinergic modulation from the medial septum/diagonal band of Broca (MSDB) is known to correlate with the speed of an animal's movements at sub-second timescales and also supports spatial memory formation. Yet...
Phasic alertness impairs cognitive control by amplifying competition between evidence accumulators [0.03%]
阶段唤醒通过放大证据积累器之间的竞争来损害认知控制
Jeshua Tromp,Franz Wurm,Federica Lucchi et al.
Jeshua Tromp et al.
Although phasic alertness generally benefits cognitive performance, it often increases the impact of distracting information, resulting in impaired decision-making and cognitive control. However, it is unclear why phasic alertness has these...
Convergence and segregation of excitatory and inhibitory afferents in the paraventricular thalamic nucleus [0.03%]
背侧丘脑旁室核兴奋性和抑制性输入的汇聚与分离
László Biró,Zsolt Buday,Kata Kóta et al.
László Biró et al.
The paraventricular thalamic nucleus (PVT) integrates subcortical signals related to arousal, stress, addiction, and anxiety with top-down cortical influences. Increases or decreases in PVT activity exert profound, long-lasting effects on b...
Presenilin loss impairs synaptic transmission and causes axonal degeneration through ryanodine receptor dysfunction, independent of γ-secretase activity [0.03%]
前 Presenilin丢失通过ryanodine受体功能障碍损害突触传递并导致轴突退行，独立于γ-分泌酶活性
Xinran Du,Longgang Niu,Michal Ragan et al.
Xinran Du et al.
Presenilin mutations are the most common cause of familial Alzheimer's disease (FAD), but the mechanisms by which they disrupt neuronal function remain unresolved, particularly in relation to γ-secretase activity. Using C. elegans, we show...