Involvement of the Endothelial N-Methyl-D-Aspartate Receptor on Vessel-Associated Positioning and Differentiation of Cortical Oligodendrocytes and on Motor Activity [0.03%]
内皮N-甲基-D-天冬氨酸受体在脑血管相关少突胶质细胞定位、分化及运动活动中的作用
Alexandre Beranger,Morgane Lafenêtre,Sabrina Lacomme et al.
Alexandre Beranger et al.
During cortical development, attachment and detachment of oligodendrocyte precursors (OPC) to microvessels play a crucial role in their positioning and differentiation. In the developing brain, endothelial cells are regionally diverse, and ...
Spatio-temporal dynamics of lateral Na+ diffusion in apical dendrites of mouse CA1 pyramidal neurons [0.03%]
鼠CA1锥体神经元顶树突侧向Na+扩散的时空动力学
Joel S E Nelson,Jan Meyer,Niklas J Gerkau et al.
Joel S E Nelson et al.
Sodium ions (Na+) are major charge carriers mediating neuronal excitation and play a fundamental role in brain physiology. Glutamatergic synaptic activity is accompanied by large transient Na+ increases, but the spatio-temporal dynamics of ...
Kappa opioid receptors control a stress-sensitive brain circuit and drive cocaine seeking [0.03%]
卡波普啡受体调控压力敏感型脑环路并促进可卡因渴求
Valentina Martinez Damonte,Lydia G Bailey,Amit Thakar et al.
Valentina Martinez Damonte et al.
Stress is a potent trigger for drug-seeking behaviors in both rodents and humans with a history of substance use. Kappa opioid receptors (kORs) play a critical role in mediating stress responses. Our previous studies in the ventral tegmenta...
Forewarned Is Forearmed: The single- and dual-brain mechanisms in Detectors from Dyads of Varying Social Distance During Deceptive Outcomes Evaluation [0.03%]
防患于未然：评估欺骗结果时不同社交距离二元关系体中预警机制的单脑与双脑机制
Rui Huang,Xiaowei Gao,Chenyu Zhang et al.
Rui Huang et al.
Preventing deception requires understanding how lie detectors process social information across social distance. Although the outcomes of such information are crucial, how detectors evaluate gains or losses from close versus distant others ...
Metallothionein III mediates Ca2+-dependent Zn2+ spikes to inhibit dendritic arborization [0.03%]
金属硫蛋白III介导Ca2+-依赖性的Zn2+脉冲抑制树突发育
Lyndsie Salvagio,Chen Zhang,Braden E Rue et al.
Lyndsie Salvagio et al.
Zinc is crucial for neuron function, but whether and how labile zinc ion (Zn2+) acts as an intracellular signaling molecule remains unclear. In this work, we investigate the relationship between Ca2+ and Zn2+ dynamics using fluorescence ima...
Mediodorsal thalamic input to striatum contributes to early action learning [0.03%]
背内侧丘脑-纹状体通路在早期动作学习中起关键作用
Emily T Baltz,Jialin He,Christina M Gremel
Emily T Baltz
Action control is hypothesized to be mediated by corticothalamo-basal ganglia loops subserving the acquisition and updating of action contingencies. Within this, the mediodorsal thalamus (MD) is thought to contribute to volitional control o...
Judy J Yoo,Elizabeth K Serafin,J Matthew Kofron et al.
Judy J Yoo et al.
Neonatal injury alters synaptic transmission in the spinal superficial dorsal horn (SDH), resulting in aberrant amplification of ascending nociceptive transmission. Astrocytes orchestrate synapse development and function across the CNS and ...
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1) [0.03%]
DISC1过表达大鼠的社会奖励学习缺陷及相应的大脑改变
José Dören,Yuliya Kupriyanova,Sandra Schäble et al.
José Dören et al.
Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately capture these deficits remain scarce. The Disr...
Behavioral timing of interictal spikes, but not rate, correlates with impaired working memory performance [0.03%]
发作间期尖波的的行为时间，而不是频率与工作记忆障碍相关
Justin D Yi,Maryam Pasdarnavab,Laura Kueck et al.
Justin D Yi et al.
In temporal lobe epilepsy, interictal spikes (IS) - hyper-synchronous bursts of network activity - occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field p...
Largely Intact but Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction [0.03%]
人阿片类物质使用障碍中主观价值的神经元表征受损但相对完整且分布广泛
Francesca M LoFaro,Maëlle C M Gueguen,Ananya Kapoor et al.
Francesca M LoFaro et al.
Addiction, particularly opioid use disorder (OUD), is often characterized by heightened propensity for risk-taking. While tolerance for risk and uncertainty varies across individuals, the elevated risk-taking in people with OUD is assumed t...