Joshua Raine,Caroline Kibat,Tirtha Das Banerjee et al.
Joshua Raine et al.
Alcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics are valuable for designing personalised interventional st...
Prenatal downregulation of CB1 cannabinoid receptors in the mouse prefrontal cortex disrupts cortical lamination and induces a transcriptional signature associated with social interaction deficits [0.03%]
孕鼠前额皮质内源大麻素系统下调诱导社交障碍表型及相关转录特征的研究
Samuel Simón-Sánchez,Femke den Boon,Daniel García-Rincón et al.
Samuel Simón-Sánchez et al.
Endocannabinoid signaling exerts a neurodevelopmental regulatory role via CB1 cannabinoid receptors (CB1Rs), which control pyramidal neuron differentiation, migration, and axonal guidance. Here, we investigated the long-lasting consequences...
Exposure to bullying engages social distress circuits in the adolescent and adult brain [0.03%]
欺凌经历会激活青少年和成人脑中的社会挫败感回路
Birgitta Paranko,Claire Garandeau,Kerttu Seppälä et al.
Birgitta Paranko et al.
Despite advances in understanding the psychological and social consequences of peer victimization, the immediate effects of bullying on the central nervous system remain elusive. Here we mapped the neural and attentional responses to simula...
Evidence for an active handoff between hemispheres during target tracking [0.03%]
目标追踪过程中左右半脑活跃切换的证据
Matthew B Broschard,Jefferson E Roy,Scott L Brincat et al.
Matthew B Broschard et al.
The brain has somewhat separate cognitive resources for the left and right sides of our visual field. Despite this lateralization, we have a smooth and unified perception of our environment. This raises the question of how the cerebral hemi...
BLTP1 is required for survival and normal development and function of the neuromuscular junction in mice [0.03%]
BLTP1是小鼠神经肌肉接头的存活、正常发育和功能所必需的蛋白质
Yun Liu,Qiaohong Ye,Dengke K Ma et al.
Yun Liu et al.
BLTP1 (Bridge-Like Lipid Transfer Protein Family Member 1), previously known as Tweek, Kiaa1109, FSA or 4932438A13Rik, is a non-vesicular lipid transport protein linked to Alkuraya-Kučinskas Syndrome (AKS), an autosomal recessive disorder ...
A neural model for V1 that incorporates dendritic nonlinearities and back-propagating action potentials [0.03%]
一种结合树突非线性和反向传播动作电位的V1神经元模型
Ilias Rentzeperis,Dario Prandi,Marcelo Bertalmío
Ilias Rentzeperis
The work of Hubel and Wiesel has been instrumental in shaping our understanding of V1, leading to modeling neural responses as cascades of linear and nonlinear processes in what is known as the "standard model" of vision. Under this formula...
Visual distortions in human amblyopia are correlated with deficits in contrast sensitivity [0.03%]
弱视的人的视觉失真与对比度敏感性下降相关
Farzaneh Olianezhad,Jianzhong Jin,Sohrab Najafian et al.
Farzaneh Olianezhad et al.
Amblyopia (lazy eye) is a developmental disorder of the visual cortex that causes deficits in visual acuity and shape perception. The loss of visual acuity is thought to originate from weakened cortical responses to stimuli. Here, we provid...
Switching patterns of cortical-subcortical interaction in the human brain [0.03%]
人类大脑皮层-皮下结构相互作用的转换模式
Alessandro Nazzi,Chiara Favaretto,Antonino Vallesi et al.
Alessandro Nazzi et al.
It is still poorly understood how subcortical structures contribute to spontaneous infraslow brain activity. In fact, cortical spontaneous activity is often analyzed in isolation, possibly a result of a long-standing 'cortico-centric bias'....
Spatiotemporal evidence accumulation through saccadic sampling for object recognition [0.03%]
借助跳视采样进行时空证据积累以实现物体识别
Zhihao Zheng,Jiaqi Hu,Gouki Okazawa
Zhihao Zheng
Visual object recognition has been extensively studied under fixation conditions, but our natural viewing involves frequent saccadic eye movements that scan multiple local informative features within an object (e.g., eyes and mouth in a fac...
Sensory Deficits in mice with Lateral Spinal Cord Hemisection Mimic the Brown-Sequard Syndrome [0.03%]
模拟Brown-Séquard综合征的小鼠半侧脊髓损伤模型中感觉功能的缺失
Melissa Henwood,Junkui Shang,Qiang Li et al.
Melissa Henwood et al.
Spinal cord injury (SCI) often results in permanent sensory deficits, significantly impairing quality of life. These deficits are poorly addressed due to a lack of valid animal models with translational relevance. Here, we utilized a thorac...