Circadian changes in CA1 LTP are driven by shifts in excitation-inhibition balance and reverse direction after puberty in mice [0.03%]
小鼠海马CA1区节律性长时程增强的变化在青春期后方向逆转系兴奋抑制平衡的改变所致
Gonzalo Valdivia,Cristian Moreno,Kaiwen He et al.
Gonzalo Valdivia et al.
Long-term potentiation (LTP), the best-characterized form of Hebbian synaptic plasticity, is well known to be under strong circadian regulation. In mice and rats, both nocturnal species, most studies indicate that LTP in the hippocampal CA1...
The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish [0.03%]
cannabidiol的促痛和非抗痛作用依赖于斑马鱼Trpa1b基因变异体
Bryce Lecamp,Quinn Bianucci,Sidhant Rauniyar et al.
Bryce Lecamp et al.
The promiscuous ligand cannabidiol (CBD) shows promise as an analgesic, but its complex pharmacodynamics has made it difficult to identify its mechanism(s) of action. Numerous putative CBD receptors including cannabinoid receptors CB1 and C...
Mesocorticostriatal reinforcement learning of state representation and value with implications for the mechanisms of schizophrenia [0.03%]
关于精神分裂症状态下表征和价值强化学习的中皮质纹状体机制研究
Kenji Morita,Arvind Kumar
Kenji Morita
Mesocorticostriatal dopamine projections are crucial for value learning, motivational control, and cognitive functions. However, while dopamine's role in value learning as reward-prediction-error (RPE) has been much understood, precise role...
Activity-dependent regulation of basal forebrain cholinergic neurons by striatal spiny projection neurons [0.03%]
纹状体锥体投射神经元通过活动依赖性调节基底前脑胆碱能神经元功能
Linqing Sun,Enrico Zampese,Tristano Pancani et al.
Linqing Sun et al.
The basal forebrain cholinergic neurons (BFCNs) in substantia innominata (SI) and nucleus basalis magnocellularis (nBM) provide dense innervation to multiple cortical areas, shaping cognition, attention, and the sleep-wake cycle. However, t...
Anterior insula activity during alcohol and social reward self-administration and choice in male and female rats [0.03%]
雄性和雌性大鼠进行酒精和社交奖赏自我给药及选择时的前绝缘体活动
Yvar van Mourik,Dustin Schetters,Ilse Bassie et al.
Yvar van Mourik et al.
Alcohol use disorder (AUD) is characterized by the prioritization of alcohol over healthier non-alcohol rewards, posing significant challenges for addiction treatment. Understanding the neural mechanisms driving this maladaptive preference ...
Ribosomal profiling of the geniculate ganglion identifies the receptor ALK as critical for the development and maintenance of oral sensory neurons [0.03%]
核糖体测序鉴定三叉神经节基因表达及识别受体ALK对口腔感觉神经元发育和维持的作用至关重要
Tao Tang,Louis J Martin,Brian A Pierchala
Tao Tang
The geniculate ganglion (GG) consists of two populations of neurons, sensory neurons that innervate the oral cavity and express the transcription factor Phox2b, and somatosensory neurons that innervate the pinna and express Brn3a To identif...
Temporal Variability in the Spiking Activity of Neurons in the External Globus Pallidus in Healthy and Parkinsonian Monkeys [0.03%]
健康猴和帕金森病猴外部苍白球神经元放电活动的时程变异性的研究
Adriana Galvan,Xing Hu,Anne-Caroline Martel et al.
Adriana Galvan et al.
The external segment of the globus pallidus (GPe) is a critical node within the indirect pathway of the basal ganglia. In vivo recordings in primates and other animals have shown that most GPe neurons exhibit high frequency firing with paus...
Movie features are hierarchically encoded in the dynamics of functional connectivity [0.03%]
电影特征在功能连接动态中分层编码
Francesco de Pasquale,Chiara De Giorgi,Stefania Della Penna et al.
Francesco de Pasquale et al.
The perception of the external environment relies on a cascade of neural computations in the visual cortex, where stimulus features are represented hierarchically. These features can be extracted through Convolutional neural networks (CNN) ...
Probabilistic Perceptual Decisions During Navigation Are Driven by Small Subpopulation of Neurons in a Single Cortical Column of Primary Somatosensory Cortex [0.03%]
在躯体感觉皮层单一柱中少量神经元亚群驱动导航过程中的概率感知决策
Alex G Armstrong,Yurii Vlasov
Alex G Armstrong
Perceptually driven behavioral choices are thought to develop gradually from sensation to perception in the somatosensory cortex to guide decision-making in higher order cortical areas. Primary somatosensory cortex (wS1) of rodents related ...
MTCL2 is essential for the bipolar-to-multipolar transition in the dendrite extension of cerebellar granule neurons [0.03%]
MTCL2对小脑颗粒神经元树突生长过程中从双极到多极的转变是必不可少的
Mari Minekawa,Toma Adachi,Mikio Hoshino et al.
Mari Minekawa et al.
The dynamic regulation of neuronal polarity is essential for the formation of neural networks during brain development. Primary cultures of rodent neurons recapitulate several aspects of this polarity regulation, providing valuable insights...