Altered Structural and Functional Connectivity of Salience Network in Patients with Classic Trigeminal Neuralgia [0.03%]
经典三叉神经痛患者的疼痛网络连接异常
Hui Xu,David A Seminowicz,Samuel R Krimmel et al.
Hui Xu et al.
Classic trigeminal neuralgia (CTN) is a neuropathic pain disorder displaying spontaneously stabbing or electric shock-like paroxysms in the face. Previous research suggests structural and functional abnormalities in brain regions related to...
Know Your Movements: Poorer Proprioceptive Accuracy is Associated With Overprotective Avoidance Behavior [0.03%]
知彼行动——本体感受准确性较差与过度保护性回避行为有关
Kristof Vandael,Alexandra Vasilache,Ann Meulders
Kristof Vandael
Pain-related avoidance of movements that are actually safe (ie, overprotective behavior) plays a key role in chronic pain disability. Avoidance is reinforced through operant learning: after learning that a certain movement elicits pain, mov...
Anti-Nociceptive and Anti-Aversive Drugs Differentially Modulate Distinct Inputs to the Rat Lateral Parabrachial Nucleus [0.03%]
抗痛觉和抗厌恶性药物差异调节大鼠外侧脑桥核的特定输入神经元
Hannah Luise Teuchmann,Roni Hogri,Bernhard Heinke et al.
Hannah Luise Teuchmann et al.
The lateral parabrachial nucleus (LPBN) plays an important role in the processing and establishment of pain aversion. It receives direct input from the superficial dorsal horn and forms reciprocal connections with the periaqueductal grey ma...
Activation of 20-HETE Synthase Triggers Oxidative Injury and Peripheral Nerve Damage in Type 2 Diabetic Mice [0.03%]
2型糖尿病小鼠20-HETE合成酶被激活后出现氧化损伤及外周神经受损现象
Mary Haddad,Stéphanie Eid,Frederic Harb et al.
Mary Haddad et al.
Diabetic Peripheral Neuropathy (DPN), highly prevalent among patients with diabetes, is characterized by peripheral nerve dysfunction. Reactive Oxygen Species (ROS) overproduction has been suggested to orchestrate diabetic complications inc...
Healthcare Transition Among Young Adults With Childhood-Onset Chronic Pain: A Mixed Methods Study and Proposed Framework [0.03%]
青年期慢性疼痛患者的医疗过渡：一种混合方法研究和建议框架
Caitlin B Murray,Lexa K Murphy,Abbie Jordan et al.
Caitlin B Murray et al.
Chronic pain extends from childhood to adulthood for many young people. The transition from pediatric to adult care is a critical, yet understudied, healthcare task facing young adults with chronic pain. The aims of this observational, sequ...
Observational Study
The journal of pain. 2022 Aug;23(8):1358-1370. DOI:10.1016/j.jpain.2022.02.010 2022
Migraine, Brain Glucose Metabolism and the "Neuroenergetic" Hypothesis: A Scoping Review [0.03%]
偏头痛、脑葡萄糖代谢和“神经能”假说：系统综述
Lorenzo Del Moro,Eugenia Rota,Elenamaria Pirovano et al.
Lorenzo Del Moro et al.
Increasing evidence suggests that migraine may be the result of an impaired brain glucose metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain glucose metabolism and gray matter volume reduction in speci...
Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure [0.03%]
FKBP51抑制剂对创伤性压力暴露后诱导的持久痛觉过敏的镇痛持续时间与给药时间有关
Britannia J Wanstrath,Samuel A McLean,Ying Zhao et al.
Britannia J Wanstrath et al.
Chronic pain development is a frequent outcome of severe stressor exposure, with or without tissue injury. Enduring stress-induced hyperalgesia (ESIH) is believed to play a central role, but the precise mechanisms mediating the development ...
Confronting Racism in All Forms of Pain Research: Reframing Study Designs [0.03%]
以各种形式应对疼痛研究中的种族主义：重新构建研究设计
Janelle E Letzen,Vani A Mathur,Mary R Janevic et al.
Janelle E Letzen et al.
This second paper in a 3-part series on antiracism in pain research across the translational spectrum focuses on study design factors. Although objectivity is a cornerstone value of science, subjectivity is embedded in every step of the res...
The Influence of Opioids on Transcutaneous Electrical Nerve Stimulation Effects in Women With Fibromyalgia [0.03%]
阿片类药物对女性纤维肌痛综合症患者经皮神经电刺激效果的影响
Dana L Dailey,Carol G T Vance,Ruth Chimenti et al.
Dana L Dailey et al.
Transcutaneous electrical nerve stimulation (TENS) uses endogenous opioids to produce analgesia, and effectiveness can be reduced in opioid-tolerant individuals'. We examined TENS effectiveness (primary aim), and differences in fibromyalgia...
Randomized Controlled Trial
The journal of pain. 2022 Jul;23(7):1268-1281. DOI:10.1016/j.jpain.2022.02.008 2022
Electrophysiological Alterations Driving Pain-Associated Spontaneous Activity in Human Sensory Neuron Somata Parallel Alterations Described in Spontaneously Active Rodent Nociceptors [0.03%]
人类感觉神经元体中与疼痛相关的自发活动的电生理变化与小鼠自发激活痛觉感受器的变化平行
Robert Y North,Max A Odem,Yan Li et al.
Robert Y North et al.
Neuropathic pain in rodents can be driven by ectopic spontaneous activity (SA) generated by sensory neurons in dorsal root ganglia (DRG). The recent demonstration that SA in dissociated human DRG neurons is associated with reported neuropat...