Patcharaporn Srisaikaew,Timur H Latypov,Daniel Jörgens et al.
Patcharaporn Srisaikaew et al.
Trigeminal neuralgia (TN), a severe chronic neuropathic pain disorder, has been associated with abnormalities in limbic structures, particularly the hippocampus. The fornix, the hippocampus's primary efferent pathway, is integral to limbic-...
New strategy for treating visceral pain: Enhancing opioid antinociception by Sigma-1 receptor inhibition [0.03%]
治疗内脏痛的新策略——通过抑制Sigma-1受体增强阿片类药物的镇痛作用
Antonia Artacho-Cordón,Miguel Á Huerta,Enrique Portillo-Salido et al.
Antonia Artacho-Cordón et al.
Visceral pain remains a major clinical challenge, often resistant to conventional analgesics. Sigma-1 receptor (σ1R) antagonists enhance opioid antinociception in somatic and neuropathic pain, yet their role in visceral nociception remains...
Temporal changes in mechanical pin prick sensitivity following high frequency induced sensitisation of central nociceptive pathways: A test re-test reliability study [0.03%]
高频电击诱导中枢痛觉敏化后机械痛阈值的变化：一项测试重复性研究
Samuel Mugglestone,Giorgio Ganis,Sam W Hughes
Samuel Mugglestone
High-frequency stimulation (HFS) is a human surrogate model of secondary hyperalgesia and a key experimental tool for understanding the mechanisms and modulation of central nociceptive pathways. An emerging area of research focuses on the r...
Pre-surgical quantitative sensory testing and post-surgical pain among adolescents undergoing spinal fusion surgery: A longitudinal cohort study [0.03%]
青少年脊柱融合手术前后定量感觉检测及术后疼痛的纵向队列研究
Ayesha C Sujan,Cornelius Groenewald,Rui Li et al.
Ayesha C Sujan et al.
Pediatric post-surgical pain is common and associated with diminished quality of life and significant medical costs. While quantitative sensory testing (QST) is a promising tool for predicting post-surgical pain in adults, research in youth...
Illuminating Ongoing Pain in Mice with Novel Bioluminescent imaging [0.03%]
采用新型生物发光成像技术揭示小鼠慢性疼痛的新标志
Subo Yuan,Jia Yi Liew,Ajay Pal et al.
Subo Yuan et al.
Objectively measuring pain in laboratory animals is essential for pain research and analgesic development. Despite the development of various behavioral tests to measure evoked pain in animal models, measuring spontaneous pain remains chall...
Bidirectional Associations Between Daily Sleep and Pain Severity in Adults with Rheumatoid Arthritis: A Daily Diary and Actigraphy Study [0.03%]
类风湿性关节炎成人每日睡眠与疼痛严重程度的双向关联：来自日常日记和活动节奏法研究的证据
Christina X Mu,Katie L Stone,Fei Jiang et al.
Christina X Mu et al.
Poor sleep and pain are common in rheumatoid arthritis (RA). This study sought to understand the temporal relationships between multidimensional sleep and pain in daily life among individuals with RA. Participants with RA completed up to fo...
Pain, pain catastrophizing, and autonomic nervous system dysfunction after traumatic injury: a prospective cohort study [0.03%]
伤害性事件后的疼痛、灾难化思维及自主神经功能障碍：前瞻性队列研究
Ilaria Pozzato,Mohit Arora,Candice McBain et al.
Ilaria Pozzato et al.
Traumatic injuries from road traffic crashes are a major global health concern, resulting in significant physical, emotional, and social consequences, with pain being a frequent outcome. Chronic pain is often accompanied by maladaptive cogn...
Patients' pain experience in claudication: biopsychosocial correlates of frequency, intensity, sleep interference, and chronic pain [0.03%]
间歇性跛行患者的疼痛体验：频度、强度、影响睡眠以及慢性疼痛的生物-心理-社会因素分析
Gaëlle Romain,Alaa Alashi,Christiany Tapia et al.
Gaëlle Romain et al.
Pain is the hallmark symptom of claudication, the early stage of peripheral artery disease (PAD), yet its relationship with psychological distress remains unclear. We described pain patterns and examined its association with PAD severity an...
Group-Format Pain Reprocessing Therapy in Veterans with Chronic Back/Neck Pain: A Pilot Study with Mixed Methods Evaluation [0.03%]
退伍军人慢性背痛/颈部疼痛的团体格式疼痛再处理治疗：混合方法评价的试点研究
Zan Wynia,John Gasienica,Rachel Amondson et al.
Zan Wynia et al.
Pain reprocessing therapy (PRT) has demonstrated efficacy for chronic back pain as delivered individually and in-person. To enhance scalability, we developed and implemented group-format telehealth PRT delivered in 8 weekly sessions. We tes...
Chronic ocular pain is associated with smaller selective hippocampal subfield in highly symptomatic patients [0.03%]
慢性眼痛与高度症状性患者选择性海马亚区较小有关
Alpen Ortug,David Valdes-Arias,Ema Karakoleva et al.
Alpen Ortug et al.
Chronic ocular pain (COP) defines any type of pain in the eye persisting for more than 3 months and is often accompanied by symptoms that extend beyond the ocular system, including central nervous system (CNS) alterations reflected in mood ...