Yannick L Gilanyi,Michael C Ferraro,Andreas Goebel et al.
Yannick L Gilanyi et al.
Complex regional pain syndrome (CRPS) is a disabling pain condition, usually confined to a single limb. Amputation of the affected limb is sometimes performed to improve pain and function for treatment-resistant CRPS. This systematic review...
Mégane Lacombe-Thibault,Michel-Pierre Coll
Mégane Lacombe-Thibault
Pain perception is modulated by expectations and learning processes, but the influence of uncertainty in this relationship is not well established. We aimed to examine the relationship between uncertainty, pain learning and perception using...
Risk factors for long-term sickness absence in patients with high-impact chronic pain - a scoping review and Swedish register-based cohort study [0.03%]
高影响慢性疼痛患者长期病假的风险因素-综述和基于瑞典登记的队列研究
Robin Larsson,Enisa Guta,Björn Äng et al.
Robin Larsson et al.
High-impact chronic pain (HICP) affects 8% of individuals worldwide. Beyond its direct consequences, HICP increases the risk of long-term sickness absence (LTSA), leading to income loss and increased societal costs. Prevention is essential ...
Predicting daily pain fluctuations in fibromyalgia: The role of mental distress and sleep heart-rate [0.03%]
纤维肌痛的每日疼痛波动预测：心理压力和睡眠心率的作用
Shir Hanuka,Naama Tamari,Eden Eldar et al.
Shir Hanuka et al.
Fibromyalgia (FM) is a chronic pain condition that typically involves sharp fluctuations in pain intensity over short time periods. Both mental distress and sleep disturbances have been implicated in FM, yet their putative contributions to ...
Prolonged Aftersensations to Thermal Noxious Stimulation as a Screening Tool for Central Contributions to Chronic Ocular Pain [0.03%]
热痛刺激的后感觉作为筛查中枢性慢性眼痛的工具
Araliya N Gunawardene,Noa Dobzinski,David Valdes-Arias et al.
Araliya N Gunawardene et al.
Painful aftersensations (AS) are sensations that persist after termination of a noxious stimulus, and prolonged AS may reflect abnormal somatosensory processing. We aimed to validate AS as indicators of central nervous system processing abn...
Cre-based functional profiling of RVM neurons implicates distinct populations in sensory-mediated behaviors [0.03%]
基于CRE的RVM神经元功能谱系分析揭示了感觉介导行为中不同神经元群体的作用
Eileen Nguyen,Ruby A Holland,Sarah E Ross
Eileen Nguyen
The rostral ventromedial medulla (RVM) has an important role in descending modulation, yet the molecular and functional diversity of RVM neurons involved in nociception remains incompletely understood. Here, we used a combination of multipl...
Nav1.8, TRPV1 and TRPA1 as possible targets of ambroxol when used for topical treatment of neuropathic pain [0.03%]
氨溴索外用治疗神经病理性疼痛时可能针对的靶点Nav1.8，TRPV1和TRPA1
Stefanie Hefner,George Oprita,Sebastian Pantke et al.
Stefanie Hefner et al.
Sodium channels and the capsaicin receptor TRPV1 in epidermal sensory nerve endings are established targets for topical treatment of neuropathic pain. The secretolytic ambroxol induces effective topically analgesia, a property that may invo...
High-impact pain predicts subjective cognitive decline and interacts with APOE4 genotype in the development of objective cognitive impairment [0.03%]
高影响疼痛可以预测主观认知下降，并与APOE4基因型相互作用以发展为客观性认知障碍
Javier A Tamargo,Glenn Smith,Li Chen et al.
Javier A Tamargo et al.
Chronic pain is the most common health challenge for older adults and a significant risk factor for cognitive impairments and dementia. This study examined the relationship of high-impact pain (i.e., pain that limits daily activities) with ...
Dissecting the neurogenetic architecture of chronic pain: a brain-wide genetics study [0.03%]
慢性疼痛的神经遗传结构解析：一项全脑范围的遗传学研究
Jinyang Gao,Yansong He,Benjin Li et al.
Jinyang Gao et al.
Chronic pain (CP) is a widespread and debilitating condition with complex neurobiological and genetic foundations. To better understand the brain-based and genetic mechanisms underlying CP, we integrated bidirectional Mendelian randomizatio...
Preclinical Perspectives on Disorders of the Temporomandibular Joint: Tracing the Past, Navigating the Present, and Shaping the Future [0.03%]
颞下颌关节紊乱的前临床研究：回顾过去，把握现在，展望未来
John K Neubert,Kyle Allen,Tamara Alliston et al.
John K Neubert et al.
Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or al...