The analgesic effect of total saponins of Tribulus terrestris on neuropathic pain was studied based on TLR4/NF-κB pathway [0.03%]
刺蒺藜总皂苷通过TLR4/NF-κB通路对神经病理性疼痛镇痛作用的研究
Wu-Xia Guo,He Zhang,Zhan-Qiang Wang et al.
Wu-Xia Guo et al.
Neuropathic pain (NP) consists of a range of unpleasant sensations attributed to a lesion or a disease of the somatosensory nervous system. It is important to note that the sensations initiated by NP are debilitating and adversely affect qu...
A simple fluorometric test method for assessing skin sensitization potential of chemicals by using N-acetyl-L-cysteine methyl ester in chemico [0.03%]
利用N-乙酰-L-半胱氨酸甲酯的化学荧光法测定化学品致皮肤过敏性的简单方法
Rahul Upadhyay Nepal,Tae Cheon Jeong
Rahul Upadhyay Nepal
The covalent binding of sensitizer to skin proteins is referred to as key event 1 of the adverse outcome pathway in skin sensitization. Recently, N-acetyl-L-cysteine methyl ester (NACME) was demonstrated to react selectively with skin sensi...
Analysis of in silico and in vivo pharmacokinetic and toxicological parameters of dillapiole n-butyl ether [0.03%]
香芹酚正丁醚的体内体外药代动力学和毒理学参数分析
Daniel Luís Viana Cruz,Ana Cristina da Silva Pinto,Mayla Silva Leão Ferreira et al.
Daniel Luís Viana Cruz et al.
The larvicidal effect of dillapiole and its semi-synthetic derivatives on Aedes aegypti (Ae. Aegypti), the main transmitter of arboviruses such as dengue (DENV), Zika (ZIKV), and Chikungunya (CHIKV), is well - established. Among dillapiole ...
Dexmedetomidine pretreatment alleviates brain injury in middle cerebral artery occlusion (MCAO) model rats by activating PI3K/AKT/NF-κB signaling pathway [0.03%]
右美托咪定通过激活PI3K/AKT/NF-κB信号通路减轻中脑动脉阻塞模型大鼠的脑损伤
Wei Gao,Xue Lv,Hao Li et al.
Wei Gao et al.
Cerebral ischemia-reperfusion injury (CIRI) is a prevalent clinical complication associated with reperfusion following ischemic stroke resulting in neuronal damage and cognitive impairment. Dexmedetomidine (DEX), a highly selective α2-adre...
Health benefits of a reduction in ambient fine particulate matter levels for post-neonatal infant survival in Taiwan [0.03%]
环境中细颗粒物浓度降低对台湾婴儿存活的健康效益
Chih-Cheng Chen,Shang-Shyue Tsai,Chien-Ning Yeh et al.
Chih-Cheng Chen et al.
Infants' and children's health is particularly susceptible to exposure to various environmental contaminant insults as their immune systems are immature and daily activities may present differing patterns of exposure. Although some studies ...
Long-term effects of acute hazardous noise on auditory and non-auditory organs [0.03%]
急性危险噪声对听觉和非听觉器官的长期影响
Li Yang,Matthew C Salanga,Tinna Traustadóttir et al.
Li Yang et al.
Hazardous noise is a pervasive environmental pollutant with significant adverse health impacts on auditory and non-auditory organs. It is noteworthy that even acute noise exposure might pose immediate detrimental effects to various organs. ...
Phytotoxicity and cytogenotoxic effects of extracts from the medicinal bark of Rhamnus purshiana DC. (Rhamnaceae) [0.03%]
药用植物Rhamnus purshiana DC. (Rhamnaceae)树皮提取物的植物毒性和细胞遗传毒性效应
Kimberly Silva Souza,Antonio Rodrigues da Cunha Neto,Daniela Aparecida Chagas-Paula et al.
Kimberly Silva Souza et al.
Natural products, although frequently associated with beneficial effects and considered harmless, still require thorough analysis; therefore, their bioactive compounds need to be used with caution. Biological assays using plant models repre...
Mutagenic assessment and toxicological impact of bergenin in a phenolic-enriched extract from Endopleura uchi (Huber) Cuatrec bark, a medicinal plant from the Amazon rainforest [0.03%]
来自亚马逊雨林的药用植物红木(Endopleura uchi)树皮中富含苯酚成分提取物中 Bergenin 的致突变性和毒理学影响评估
Elkejer Ribeiro da Cruz,Dione Silva Corrêa,Jéssica Machado Miri et al.
Elkejer Ribeiro da Cruz et al.
Endopleura uchi bark traditionally used in folk medicine attributed to its anti-inflammatory properties is due to the presence of bergenin. This study aimed to determine the toxicological parameters associated with exposure to a phenolic-en...
MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway [0.03%]
MC-LR通过JAK1/STAT3信号通路诱导并加剧小鼠结肠炎
Xiaodie Zhou,Yue Yang,Canqun Yan et al.
Xiaodie Zhou et al.
Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder attributed to genetic and environmental factors. Microcystin-leucine-arginine (MC-LR) is an environmental toxin that accumulates in the gut and produces intestinal dama...
Dose-response effect of polyphenon-60 from green tea (P60-GT) on hexavalent chromium-induced genotoxic damage and apoptosis in mice [0.03%]
绿茶多酚P60-GT对六价铬致小鼠遗传毒性损伤及凋亡的剂量效应关系研究
Lourdes Montserrat Hernández-Cortés,Víctor Manuel Mendoza-Núñez,Alda Rocío Ortiz-Muñiz et al.
Lourdes Montserrat Hernández-Cortés et al.
This study aimed to examine the dose-response effects of polyphenon-60 derived from green tea (P60-GT) on hexavalent chromium [Cr(VI)]-induced genotoxic damage and apoptosis. Male Hsd:ICR mice were divided into 4 groups: (1) Control (vehicl...