Jay N Giedd,Rhoshel K Lenroot,Philip Shaw et al.
Jay N Giedd et al.
Many cognitive, emotional and behavioural traits, as well as psychiatric disorders are highly heritable. However, identifying the specific genes and mechanisms by which this heritability manifests has been elusive. One approach to make this...
H Akil,S J Evans,C A Turner et al.
H Akil et al.
While there has been a great deal of interest in the role of brain-derived neurotrophic factor (BDNF) in mood disorders and/or the mode of action of antidepressants, less is known about the role of other growth factors. This paper is focuse...
David A Talmage
David A Talmage
Neuregulin 1 (Nrg1) and ErbB receptor tyrosine kinase signalling is essential for the formation and proper functioning of multiple organ systems and inappropriate Nrgl/ErbB signalling severely compromises health, contributing to such divers...
Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism [0.03%]
双相情感障碍的遗传学：BDNF Val66Met多态性的研究
Jinbo Fan,Pamela Sklar
Jinbo Fan
Bipolar disorder is a chronic severe mood disorder that has been consistently demonstrated to have a strong inherited component. Traditional approaches to gene discovery have produced conflicting results regarding the association between ge...
Eero Castrén,Tomi Rantamäki
Eero Castrén
Neurotrophins are important regulators of neuronal plasticity in the developing and adult brain. In particular, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are implicated in these functions. The synthesis and release of B...
Jonathan Flint,Sagiv Shifman,Marcus Munafo et al.
Jonathan Flint et al.
Major depression is one of the most common and most debilitating disorders in the world. A wealth of data indicate that additive genetic effects contribute to at least 30% of the variance in liability to major depression, yet attempts to id...
Daniel C Javitt
Daniel C Javitt
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. Traditional models of schizophrenia have emphasized dopaminergic dysfunction. Over the last 15 years, however, glutamatergic models have become in...
Moses Chao
Moses Chao
Focal brain malformations: a spectrum of disorders along the mTOR cascade [0.03%]
焦点性脑畸形：mTOR途径的一系列综合症
Peter B Crino
Peter B Crino
Focal cortical dysplasia with balloon cells (FCDIIB), hemimegalencephaly (HMEG), and ganglioglioma (GG) are sporadic focal malformations of cortical development that are highly associated with epilepsy. Histologically, all three malformatio...
Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1 [0.03%]
精神分裂症易患基因及其对神经发育的意义：重点在于神经营养素-1
Paul J Harrison
Paul J Harrison
On the basis of epidemiological as well as neurobiological evidence, schizophrenia has been conceptualized as a neurodevelopmental disorder. It is also known to have a large heritable component and a complex genetic architecture. Many putat...