Pere Santamaria
Pere Santamaria
CD8+ T cells are important contributors to the initiation and progression of type 1 diabetes (T1D). A very significant fraction of islet-associated CD8 T cells in NOD mice recognize epitopes of islet-specific glucose-6-phosphatase catalytic...
Translating mucosal antigen based prevention of autoimmune diabetes to human [0.03%]
基于黏膜抗原预防自身免疫性糖尿病向人类转化
Ezio Bonifacio,Anette Ziegler,Peter Achenbach et al.
Ezio Bonifacio et al.
Mucosal administration of autoantigen (insulin) to animal models has been demonstrated to be effective in preventing autoimmune diabetes. Efficacy is dependent upon the dose and the age at which it is delivered. Because of its low toxicity,...
Re-establishing immune tolerance in type 1 diabetes via regulatory T cells [0.03%]
通过调节性T细胞重新建立自身免疫耐受以治疗I型糖尿病
Silvia Gregori,Manuela Battaglia,Maria-Grazia Roncarolo
Silvia Gregori
Type 1 diabetes (T1D) is a disease in which tolerance to self-antigens, such as insulin, is broken leading to expansion of autoreactive T cells that attack pancreatic beta cells with consequent loss of insulin production. Regulatory T cells...
Bart O Roep
Bart O Roep
Type 1 diabetes results from a T cell-mediated autoimmune destruction of the insulin-producing pancreatic beta cells in subjects with a genetic predisposition to this disease. Therapies directed against T cells have been shown to halt the d...
Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass [0.03%]
向I型糖尿病的治愈性疗法迈进：自身免疫缓解和β细胞数量维持及扩充
Frank Waldron-Lynch,Matthias von Herrath,Kevan C Herold
Frank Waldron-Lynch
Recent clinical trials have shown that the loss of insulin production that characterizes progressive type 1 diabetes mellitus can be attenuated by treatment with non-FcR binding anti-CD3 monoclonal antibody (mAb). This approach is a first s...
Mark Peakman
Mark Peakman
The intra-islet cellular infiltrate found at post mortem in patients with new-onset Type 1 diabetes mellitus (T1DM) comprises both CD4+ and CD8+ cells, yet very few studies have investigated CD8 T cell responses to islet autoantigens. We th...
Teodora Staeva
Teodora Staeva
Halting the autoimmune attack on beta cells by redirecting or dampening the immune system remains one of the foremost therapeutic goals in type 1 diabetes (T1D). Progress in the field has been slow due to important ethical considerations. N...
Li Zhang,Roberto Gianani,Maki Nakayama et al.
Li Zhang et al.
A wealth of data in animal models indicates that type 1A diabetes results from T cell-mediated specific destruction of islet beta cells. There is evidence for the NOD mouse model that insulin is the primary autoantigen and a specific insuli...
Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice [0.03%]
非肥胖糖尿病小鼠胰岛β细胞的破坏机制与细胞毒性T淋巴ocyte的关系研究
Thomas W H Kay,Nadine L Dudek,Kate Graham et al.
Thomas W H Kay et al.
CD8+ T cells are the principal cellular mediators of beta cell destruction in the NOD mouse. Molecular mediators include perforin and granzymes from the cytotoxic granule, Fas ligand and pro-inflammatory cytokines. Our studies in NOD mice h...
Damien Bresson,Matthias von Herrath
Damien Bresson
Induction of 'adaptive' regulatory T cells (Tregs) using islet-specific antigen vaccinations has been shown to prevent disease in various animal models for type 1 diabetes (T1D). Even though translation from bench to bedside has been unsucc...