Stereoelectroencephalography-guided laser ablation in neocortical epilepsy: Electrophysiological correlations and outcome [0.03%]
立体脑电图指导下的新皮质癫痫激光消融术：电生理相关性及疗效研究
Thandar Aung,Olesya Grinenko,Jian Li et al.
Thandar Aung et al.
Objective: We aimed to study the correlation between seizure outcomes in patients with drug-resistant epilepsy (DRE) who underwent laser interstitial thermal therapy (LITT) and stereoelectroencephalographic electrophysiol...
Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial [0.03%]
氟西泮在Dravet综合征治疗中的效果：第三次随机、双盲、安慰剂对照临床试验结果
Joseph Sullivan,Lieven Lagae,J Helen Cross et al.
Joseph Sullivan et al.
Objective: This study was undertaken to assess the safety and efficacy of fenfluramine in the treatment of convulsive seizures in patients with Dravet syndrome. ...
Laura de Diego-Garcia,Gary P Brennan,Theresa Auer et al.
Laura de Diego-Garcia et al.
Objective: Posttranscriptional mechanisms are increasingly recognized as important contributors to the formation of hyperexcitable networks in epilepsy. Messenger RNA (mRNA) polyadenylation is a key regulatory mechanism g...
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy [0.03%]
一种新的非竞争性GABA转运蛋白-1抑制剂(E2730)对侧脑室海马体内递送的慢性内侧颞叶癫痫发作有抑制作用
Idrish Ali,Juliana Silva,Pablo M Casillas-Espinosa et al.
Idrish Ali et al.
Objective: More than one third of mesial temporal lobe epilepsy (MTLE) patients are resistant to current antiseizure medications (ASMs), and half experience mild-to-moderate adverse effects of ASMs. There is therefore a s...
Both epilepsy and anti-seizure medications affect bone metabolism in children with self-limited epilepsy with centrotemporal spikes [0.03%]
儿童良性中央颞叶癫痫本身及其抗癫痫治疗均影响骨代谢
Xiu-Yu Shi,Jun Ju,Qian Lu et al.
Xiu-Yu Shi et al.
Objective: Bone metabolism can be influenced by a range of factors. We selected children with self-limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for t...
Later onset focal epilepsy with roots in childhood: Evidence from early learning difficulty and brain volumes in the Human Epilepsy Project [0.03%]
成人起病局灶性癫痫的儿童起源证据：来自人类癫痫项目早期学习困难和脑体积的研究
Jacob Pellinen,Heath Pardoe,Stefan Sillau et al.
Jacob Pellinen et al.
Objective: Visual assessment of magnetic resonance imaging (MRI) from the Human Epilepsy Project 1 (HEP1) found 18% of participants had atrophic brain changes relative to age without known etiology. Here, we identify the ...
Impact on carbamazepine usage and cutaneous adverse reactions before and after the reimbursement of HLA-B*1502 genotyping in Taiwan, 2000-2017: A nationwide longitudinal study [0.03%]
台湾HLA-B*1502基因分型纳入给付前后 Carbamazepine用药及皮肤不良反应之变化：2000年至2017年全国世代纵向研究
Bao-Luen Chang,Jia-Rou Liu,Shu-Hao Chang et al.
Bao-Luen Chang et al.
Objective: The HLA-B*1502 allele is strongly associated with carbamazepine (CBZ)-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in the Han Chinese population. This study investigated the impact of H...
Identification of drug resistance in a validated cohort of incident epilepsy patients in the Danish National Patient Register [0.03%]
基于丹麦全国病人登记资料的初诊癫痫患者抗药性识别及其验证队列研究
Eva Bølling-Ladegaard,Julie W Dreier,Jakob Christensen
Eva Bølling-Ladegaard
Objective: The main purposes of this study were to validate the epilepsy diagnosis in incident epilepsy cases in the Danish National Patient Registry (DNPR), which contains information on nearly 9 000 000 individuals, and...
Quantifying and controlling the impact of regression to the mean on randomized controlled trials in epilepsy [0.03%]
量化并控制回归均值对癫痫随机对照试验的影响及其控制方法
Daniel M Goldenholz,Eliana B Goldenholz,Ted J Kaptchuk
Daniel M Goldenholz
Objective: Randomized controlled trials (RCTs) in epilepsy for drug treatments are plagued by high costs. One potential remedy is to reduce placebo response via better control over regression to the mean (RTM). Here, RTM ...
Waroth Pipatpratarnporn,Wichuta Muangthong,Suda Jirasakuldej et al.
Waroth Pipatpratarnporn et al.
Objective: This study was undertaken to describe extracerebral biosignal characteristics of overall and various seizure types as compared with baseline physical activities using multimodal devices (Empatica E4); develop p...