Insafe Mezjan,Fabien Rech,Olivier Aron et al.
Insafe Mezjan et al.
Objective: This study investigates the neural substrates of picture naming (PN) using stereoelectroencephalographic (SEEG) stimulations and evaluates the contribution of white matter (WM) fascicles related to the basal te...
Depolarization block paradoxically drives surges of neurotransmitter release during seizure activity [0.03%]
去极化阻滞在癫痫活动中会矛盾地引发神经递质释放的爆发现象
Wei Duan,Zongyi Xu,Suixin Deng et al.
Wei Duan et al.
Objective: This study was undertaken to investigate the mechanisms underlying the paradoxical phenomena of excessive neurotransmitter release and suppressed sodium-spike generation due to depolarization block (DB) during ...
Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats [0.03%]
癫痫发作对KA致痫大鼠二氧化碳反应的影响机制研究
Auriane Apaire,Elise Collard,Abigail Niyibizi et al.
Auriane Apaire et al.
Objective: Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic-clonic seizures. Inter...
Anushika Raheja,Zhibin Tan,Kaavya Narasimhalu
Anushika Raheja
The selection of anti-seizure medications (ASMs) in epilepsy remains largely empirical, leading to varied efficacy and a significant burden of adverse drug reactions (ADRs). A pharmacogenomic-based strategy can be used to personalize ASM se...
The prevalence and determinants of epilepsy in Ghana: A population-based study in two districts using a three-stage approach [0.03%]
2017年加纳人口双区癫痫患病率及影响因素研究：一种三阶段方法
Emmanuel Kwame Darkwa,Sabina Asiamah,Elizabeth Awini et al.
Emmanuel Kwame Darkwa et al.
Objective: Epilepsy imposes a disproportionate burden in Africa, yet there are no reliable epidemiological data from Ghana. This community-based cross-sectional survey addressed this gap in southeastern Ghana, incorporati...
Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development [0.03%]
跨越频率聆听：捕捉所有患者的发作以推进抗癫痫药物开发
Stéphane Auvin,Jacqueline French
Stéphane Auvin
Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options ha...
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy [0.03%]
WONOEP第17次会议评述：细胞外基质在癫痫发病中的作用
Eleonora Lugara,Erwin A van Vliet,Alessia Romagnolo et al.
Eleonora Lugara et al.
The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brai...
Review
Epilepsia. 2026 May 7. DOI:10.1002/epi.70278 2026
Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations [0.03%]
环状染色体20综合征的管理：叙事性回顾与共识建议
Asma Khamis,Emilia Ricci,Maria Paola Canevini et al.
Asma Khamis et al.
Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there i...
Review
Epilepsia. 2026 May 7. DOI:10.1002/epi.70266 2026
Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study [0.03%]
叶酸补充与女性癫痫患者后代不良结局的预防：一项观察性研究
Yutong Fu,Fanfan Shi,Leihao Sha et al.
Yutong Fu et al.
Objective: Folic acid (FA) is essential for fetal development, while the benefits and optimal dose in pregnant women with epilepsy (PWWE) remain unclear. This study explores effects of FA supplementation, dose, and initia...
Increased interval between seizure clusters across time in pediatric patients treated with the immediate-use seizure medication diazepam nasal spray [0.03%]
接受地西泮鼻喷雾即刻治疗的儿科患者的发作簇间隔时间延长
James W Wheless,Eric Segal,Jurriaan M Peters et al.
James W Wheless et al.
Objective: Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti-seizure medication. Benzodiazepine-containing immed...