RNA therapeutics for epilepsy: An emerging modality for drug discovery [0.03%]
用于癫痫的RNA疗法：药物发现的一种新兴模式
Stine N Hansen,Anja Holm,Sakari Kauppinen et al.
Stine N Hansen et al.
Drug discovery in epilepsy began with the finding of potassium bromide by Sir Charles Locock in 1857. The following century witnessed the introduction of phenotypic screening tests for discovering antiseizure medications (ASMs). Despite the...
Added value of advanced workup after the first seizure: A 7-year cohort study [0.03%]
首次发作后进行高级检查的附加价值：一项7年的队列研究
Pia De Stefano,Eric Ménétré,Patrick Stancu et al.
Pia De Stefano et al.
Objective: This study was undertaken to establish whether advanced workup including long-term electroencephalography (LT-EEG) and brain magnetic resonance imaging (MRI) provides an additional yield for the diagnosis of ne...
Revisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force [0.03%]
重温耐药性癫痫的概念：ILAE/AES联合转化特遣部队TASK1报告
Stéphane Auvin,Aristea S Galanopoulou,Solomon L Moshé et al.
Stéphane Auvin et al.
Despite progress in the development of anti-seizure medications (ASMs), one third of people with epilepsy have drug-resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 201...
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti-seizure agents [0.03%]
桥联双环化合物：作为潜在的抗惊厥剂理解一种新型化合物类别的作用机制
Samantha E Stilley,Akshay S Naraine,Krishna P Yadavalli et al.
Samantha E Stilley et al.
Objective: In the present study, we describe a novel class of small-molecule synthetic compounds that ameliorate seizure-like behavior, using an electroshock assay to examine seizure duration in Caenorhabditis elegans. We...
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures [0.03%]
新生儿癫痫发作的治疗：ILAE新生儿癫痫发作工作组特别报告的指南和共识建议
Ronit M Pressler,Nicholas S Abend,Stéphan Auvin et al.
Ronit M Pressler et al.
Seizures are common in neonates, but there is substantial management variability. The Neonatal Task Force of the International League Against Epilepsy (ILAE) developed evidence-based recommendations about antiseizure medication (ASM) manage...
Meta-Analysis
Epilepsia. 2023 Oct;64(10):2550-2570. DOI:10.1111/epi.17745 2023
Leveraging the resting brain to predict memory decline after temporal lobectomy [0.03%]
利用静息态脑网络预测颞叶切除术后记忆下降风险
Sam Audrain,Alexander Barnett,Pedram Mouseli et al.
Sam Audrain et al.
Objective: Predicting memory morbidity after temporal lobectomy in patients with temporal lobe epilepsy (TLE) relies on indices of preoperative temporal lobe structural and functional integrity. However, epilepsy is incre...
Genetic influences on epilepsy outcomes: A whole-exome sequencing and health care records data linkage study [0.03%]
癫痫预后的遗传影响：全外显子组测序和医疗记录数据关联研究
Beata Fonferko-Shadrach,Arron S Lacey,Huw Strafford et al.
Beata Fonferko-Shadrach et al.
Objective: This study was undertaken to develop a novel pathway linking genetic data with routinely collected data for people with epilepsy, and to analyze the influence of rare, deleterious genetic variants on epilepsy o...
Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force [0.03%]
体外研究能否助力抗癫痫治疗的开发和使用？国际癫痫病联盟/美洲癫痫病学会联合转化医学工作组报告
Gareth Morris,Massimo Avoli,Christophe Bernard et al.
Gareth Morris et al.
In vitro preparations (defined here as cultured cells, brain slices, and isolated whole brains) offer a variety of approaches to modeling various aspects of seizures and epilepsy. Such models are particularly amenable to the application of ...
Postoperative de novo epilepsy after resection of brain arteriovenous malformations: A national database study of 536 patients [0.03%]
脑动静脉畸形手术后新发癫痫：对536例患者的全国性数据库研究
Georgios S Sioutas,Chandrasekhar Palepu,Mohamed M Salem et al.
Georgios S Sioutas et al.
Objective: We aimed to assess the incidence and risk factors for de novo epilepsy after arteriovenous malformation (AVM) resection and compare them with a nonresection cohort after propensity score matching, utilizing a n...
Jurriaan M Peters,Danielle A Becker,Amit Verma et al.
Jurriaan M Peters et al.